Nuclear Lamins: Their Structure, Assembly, and Interactions

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

The nuclear lamina is a meshwork of intermediate-type filaments

1986 • 957 citations

The nuclear envelope lamina is reversibly depolymerized during mitosis

1980 • 956 citations

Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy

1994 • 874 citations

Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

1986 • 836 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

1997 • 753 citations

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.

1986 • 711 citations

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses

1991 • 647 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C

1993 • 608 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution.

1978 • 527 citations

Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation

1993 • 525 citations

Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study

1989 • 520 citations

The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins.

1982 • 432 citations

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering

1992 • 406 citations

Interaction between an Integral Protein of the Nuclear Envelope Inner Membrane and Human Chromodomain Proteins Homologous to HP1

1996 • 398 citations

A cell free system to study reassembly of the nuclear envelope at the end of mitosis

1986 • 382 citations

The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein

1996 • 373 citations

A lamin B receptor in the nuclear envelope.

1988 • 370 citations

Isolation of nuclear pore complexes in association with a lamina.

1975 • 367 citations

Interphase Nuclei of Many Mammalian Cell Types Contain Deep, Dynamic, Tubular Membrane-bound Invaginations of the Nuclear Envelope

1997 • 365 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Domain-specific Interactions of Human HP1-type Chromodomain Proteins and Inner Nuclear Membrane Protein LBR

1997 • 351 citations

A lamin-independent pathway for nuclear envelope assembly.

1990 • 350 citations

Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B

1987 • 347 citations

Structure and Assembly Properties of the Intermediate Filament Protein Vimentin: The Role of its Head, Rod and Tail Domains

1996 • 340 citations

The genetic basis of epidermolytic hyperkeratosis: A disorder of differentiation-specific epidermal keratin genes

1992 • 339 citations

Emerin deficiency at the nuclear membrane in patients with Emery-Dreif uss muscular dystrophy

1996 • 337 citations

Human Lamin B Contains a Farnesylated Cysteine Residue

1989 • 324 citations

Binding of matrix attachment regions to lamin B1

1992 • 318 citations

Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells

1995 • 315 citations

Intermediate filament structure

1992 • 297 citations

A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones.

1995 • 292 citations

A leucine→proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

1992 • 284 citations

Disruption of Nuclear Lamin Organization Alters the Distribution of Replication Factors and Inhibits DNA Synthesis

1997 • 281 citations

Dynamic properties of nuclear lamins: lamin B is associated with sites of DNA replication.

1994 • 271 citations

Keratin Intermediate Filament Structure

1993 • 260 citations

Evidence for modification of lamin B by a product of mevalonic acid.

1988 • 254 citations

Internal lamin structures within G1 nuclei of human dermal fibroblasts

1993 • 241 citations

Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane

1994 • 240 citations

Binding of matrix attachment regions to lamin polymers involves single-stranded regions and the minor groove.

1994 • 240 citations

cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells.

1993 • 239 citations

Insertional Mutation of the Drosophila Nuclear Lamin Dm0 Gene Results in Defective Nuclear Envelopes, Clustering of Nuclear Pore Complexes, and Accumulation of Annulate Lamellae

1997 • 228 citations

Isoprenylation is required for the processing of the lamin A precursor.

1990 • 228 citations

Cell type-specific expression of nuclear lamina proteins during development of Xenopus laevis

1985 • 227 citations

The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope

1989 • 227 citations

Stepwise reassembly of the nuclear envelope at the end of mitosis

1993 • 220 citations

Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm.

1988 • 217 citations

Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane.

1995 • 216 citations

Changes in the nuclear lamina composition during early development of Xenopus laevis

1985 • 214 citations

Integral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina.

1988 • 213 citations

A- and B-type lamins are differentially expressed in normal human tissues

1997 • 211 citations

Differential expression of nuclear lamin proteins during chicken development.

1987 • 205 citations

The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2.

1991 • 200 citations

Identification and Cloning of an mRNA Coding for a Germ Cell-Specific A-Type Lamin in Mice

1994 • 198 citations

Maturation of nuclear lamin A involves a specific carboxy‐terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina

1989 • 198 citations

Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery

1990 • 197 citations

Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

1994 • 195 citations

Structure of intermediate filaments

1983 • 195 citations

Interactions and structure of the nuclear pore complex revealed by cryo-electron microscopy.

1989 • 193 citations

An Alternative Splicing Product of the Lamin A/C Gene Lacks Exon 10

1996 • 193 citations

Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.

1991 • 188 citations

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.

1992 • 187 citations

Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif.

1989 • 183 citations

Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope.

1995 • 181 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

The role of lamin LIII in nuclear assembly and DNA replication, in cell-free extracts ofXenopuseggs

1991 • 180 citations

The role of isoprenylation in membrane attachment of nuclear lamins: A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties

1994 • 179 citations

Intermediate filament structure: 3. Analysis of sequence homologies

1988 • 178 citations

THE CYTOSKELETON AND DISEASE: Genetic Disorders of Intermediate Filaments

1996 • 177 citations

Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions.

1991 • 176 citations

Structure of α-keratin: Structural implication of the amino acid sequences of the type I and type II chain segments

1977 • 169 citations

Diversity of intermediate filament structure. Evidence that the alignment of coiled-coil molecules in vimentin is different from that in keratin intermediate filaments.

1993 • 167 citations

The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation.

1993 • 161 citations

Structural features in the heptad substructure and longer range repeats of two-stranded α-fibrous proteins

1990 • 161 citations

The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope.

1996 • 160 citations

Pathway of incorporation of microinjected lamin A into the nuclear envelope.

1992 • 160 citations

The alpha-helical rod domain of human lamins A and C contains a chromatin binding site.

1993 • 157 citations

Expression of Drosophila lamin C is developmentally regulated: analogies with vertebrate A-type lamins

1995 • 156 citations

Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions

1998 • 155 citations

Lamin B distribution and association with peripheral chromatin revealed by optical sectioning and electron microscopy tomography.

1993 • 153 citations

Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations.

1992 • 152 citations

Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin

1990 • 145 citations

βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle

1996 • 143 citations

Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro.

1990 • 135 citations

Keratin-like proteins that coisolate with intermediate filaments of BHK-21 cells are nuclear lamins.

1986 • 135 citations

Cytoplasmic intermediate filament proteins of invertebrates are closer to nuclear lamins than are vertebrate intermediate filament proteins; sequence characterization of two muscle proteins of a nematode.

1989 • 134 citations

Interaction of Xenopus lamins A and LII with chromatin in vitro mediated by a sequence element in the carboxyterminal domain

1991 • 132 citations

Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene [published erratum appears in J Cell Biol 1988 Jun;106(6):2225]

1988 • 130 citations

The role of the head and tail domain in lamin structure and assembly: Analysis of bacterially expressed chicken Lamin A and truncated B2 lamins

1992 • 130 citations

Intermediate filament structure and assembly

1993 • 130 citations

The Nuclear Pore Complex and Lamina: Three-dimensional Structures and Interactions Determined by Field Emission In-lens Scanning Electron Microscopy

1996 • 128 citations

Cells of the cellular immune and hemopoietic system of the mouse lack lamins A/C: distinction Versus other somatic cells

1990 • 127 citations

Structure of an invertebrate gene encoding cytoplasmic intermediate filament (IF) proteins: implications for the origin and the diversification of IF proteins.

1990 • 127 citations

The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro.

1992 • 127 citations

The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products.

1996 • 126 citations

Unifying principles in intermediate filament (IF) structure and assembly

1988 • 124 citations

The nuclear envelope

1989 • 122 citations

Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex.

1993 • 122 citations

Making heads and tails of intermediate filament assembly, dynamics and networks

1994 • 120 citations

Lamin-binding Fragment of LAP2 Inhibits Increase in Nuclear Volume during the Cell Cycle and Progression into S Phase

1997 • 118 citations

Gene structure of nuclear lamin LIII of Xenopus laevis; a model for the evolution of IF proteins from a lamin-like ancestor.

1990 • 117 citations

cDNA Cloning and Characterization of Lamina-associated Polypeptide 1C (LAP1C), an Integral Protein of the Inner Nuclear Membrane

1995 • 117 citations

Cell cycle-dependent methyl esterification of lamin B.

1987 • 116 citations

Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A- and B-type lamins

1989 • 115 citations

Internuclear exchange of an inner nuclear membrane protein (p55) in heterokaryons: in vivo evidence for the interaction of p55 with the nuclear lamina.

1990 • 112 citations

GST-lamin fusion proteins act as dominant negative mutants in Xenopusegg extract and reveal the function of the lamina in DNA replication

1997 • 112 citations

Targeting of membranes to sea urchin sperm chromatin is mediated by a lamin B receptor-like integral membrane protein.

1996 • 111 citations

Modulation of keratin intermediate filament assembly by single amino acid exchanges in the consensus sequence at the C-terminal end of the rod domain

1991 • 109 citations

Expression in escherichia coli of human lamins A and C: influence of head and tail domains on assembly properties and paracrystal formation

1991 • 109 citations

A new lamin in Xenopus somatic tissues displays strong homology to human lamin A.

1987 • 106 citations

Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2

1992 • 104 citations

RNP Export is Mediated by Structural Reorganization of the Nuclear Pore Basket

1996 • 100 citations

Chemical cross‐linking indicates a staggered and antiparallel protofilament of desmin intermediate filaments and characterizes one higher‐level complex between protofilaments

1992 • 95 citations

A Nuclear Envelope-associated Kinase Phosphorylates Arginine-Serine Motifs and Modulates Interactions between the Lamin B Receptor and Other Nuclear Proteins

1996 • 95 citations

The inner nuclear membrane protein p58 associates in vivo with a p58 kinase and the nuclear lamins.

1992 • 94 citations

Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein.

1992 • 94 citations

The control of DNA replication in a cell-free extract that recapitulates a basic cell cycle in vitro

1988 • 91 citations

Intermediate filament structure: 1. Analysis of IF protein sequence data

1985 • 90 citations

Polymorphism of reconstituted human epidermal keratin filaments: Determination of their mass-per-length and width by scanning transmission electron microscopy (STEM)

1985 • 88 citations

Structure and Mapping of the Human Thymopoietin (TMPO) Gene and Relationship of Human TMPO β to Rat Lamin-Associated Polypeptide 2

1995 • 87 citations

Assembly and cell cycle dynamics of the nuclear lamina

1992 • 87 citations

Change of karyoskeleton during spermatogenesis of Xenopus: expression of lamin LIV, a nuclear lamina protein specific for the male germ line.

1985 • 85 citations

Intermediate Filament Protein Polymerization: Molecular Analysis ofDrosophilaNuclear Lamin Head-to-Tail Binding

1996 • 85 citations

Lamin activity is essential for nuclear envelope assembly in a Drosophila embryo cell-free extract.

1992 • 84 citations

Concurrence between the Molecular Overlap Regions in Keratin Intermediate Filaments and the Locations of Keratin Mutations in Genodermatoses

1993 • 84 citations

Domain-Specific Disassembly and Reassembly of Nuclear Membranes during Mitosis

1997 • 84 citations

Lamins and lamin-associated proteins

1994 • 79 citations

Coiled coil formation and sequence regularities in the helical regions of α-keratin

1978 • 79 citations

Intermediate Filament Formation by a Yeast Protein Essential for Organelle Inheritance

1993 • 78 citations

Xenopus lamin b3 has a direct role in the assembly of a replication competent nucleus: Evidence from cell-free egg extracts

1995 • 78 citations

Mutations in the H1 and 1A Domains in the Keratin 1 Gene in Epidermolytic Hyperkeratosis

1994 • 77 citations

Intermediate Filament Structure

1990 • 77 citations

Mitotic Phosphorylation of the Lamin B Receptor by a Serine/Arginine Kinase and p34

1997 • 76 citations

The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles

1997 • 75 citations

High‐resolution field‐emission scanning electron microscopy of nuclear pore complex

1997 • 75 citations

Assembly of a tail-less mutant of the intermediate filament protein, vimentin, in vitro and in vivo.

1992 • 74 citations

Analysis of the mechanism of assembly of mouse keratin 1/keratin 10 intermediate filaments in vitro suggests that intermediate filaments are built from multiple oligomeric units rather than a unique tetrameric building block

1991 • 73 citations

The roles of the rod end and the tail in vimentin IF assembly and IF network formation

1993 • 72 citations

Protein Kinase C-mediated Interphase Lamin B Phosphorylation and Solubilization

1997 • 70 citations

Lamin B methylation and assembly into the nuclear envelope

1989 • 70 citations

Epidermolysis Bullosa Simplex

2009 • 69 citations

Structural studies on lamin. Similarities and differences between lamin and intermediate-filament proteins

1986 • 68 citations

A cDNA from Drosophila melanogaster encodes a lamin C-like intermediate filament protein

1993 • 68 citations

The lamin B receptor‐associated protein p34 shares sequence homology and antigenic determinants with the splicing factor 2‐associated protein p32

1994 • 67 citations

Conservation of the structure of keratin intermediate filaments: Molecular mechanism by which different keratin molecules integrate into preexisting keratin intermediate filaments during differentiation

1993 • 67 citations

Genetic Bases of Epidermolysis Bullosa Simplex and Epidermolytic Hyperkeratosis

1994 • 66 citations

Computational Methods in Genome Research

1994 • 66 citations

Organization of coiled-coil molecules in native mouse keratin 1/keratin 10 intermediate filaments: Evidence for alternating rows of antiparallel in-register and antiparallel staggered molecules

1991 • 66 citations

Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state

1996 • 61 citations

Maturation-promoting factor and the regulation of the cell cycle

1989 • 60 citations

Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis.

1994 • 59 citations

In vitro reconstitution of recombinant lamin A and a lamin A mutant lacking the carboxy-terminal tail.

1991 • 58 citations

Colocalization of vertebrate lamin B and lamin B receptor (LBR) in nuclear envelopes and in LBR-induced membrane stacks of the yeast Saccharomyces cerevisiae.

1994 • 58 citations

Assembly of A- and B-type lamins studied in vivo with the baculovirus system

1997 • 57 citations

Genetic skin diseases caused by mutations in keratin intermediate filaments

1993 • 56 citations

Characterization of the Chromatin Binding Activity of Lamina-Associated Polypeptide (LAP) 2

1997 • 56 citations

Characterization and quantitation of three B-type lamins in Xenopus oocytes and eggs: increase of lamin LI protein synthesis during meiotic maturation

1996 • 55 citations

Lamins A and C are not expressed at early stages of human lymphocyte differentiation

1990 • 54 citations

In vivo phosphorylation of the lamin B receptor. Binding of lamin B to its nuclear membrane receptor is affected by phosphorylation.

1990 • 53 citations

Localization and Posttranslational Modifications of Otefin, a Protein Required for Vesicle Attachment to Chromatin, during Drosophila melanogaster Development

1997 • 51 citations

Targeting lamin proteins to the nuclear envelope: the role of CaaX box modifications

1992 • 48 citations

Distinct Regions Specify the Targeting of Otefin to the Nucleoplasmic Side of the Nuclear Envelope

1997 • 45 citations

Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract

1996 • 44 citations

Ectopic expression of an A-type lamin does not interfere with differentiation of lamin A-negative embryonal carcinoma cells

1991 • 44 citations

Nuclear membrane vesicle targeting to chromatin in a Drosophila embryo cell-free system.

1997 • 35 citations

Characterization of p18, a Component of the Lamin B Receptor Complex and a New Integral Membrane Protein of the Avian Erythrocyte Nuclear Envelope

1996 • 35 citations

Molecular analysis of the Drosophila nuclear lamin gene

1990 • 34 citations

The organization of the gene for Drosophila lamin C: limited homology with vertebrate lamin genes and lack of homology versus the Drosophila lamin Dmo gene.

1994 • 33 citations

Immunolocalization of lamins and nuclear pore complex proteins by atomic force microscopy

1995 • 33 citations

The importance of intramolecular ion pairing in intermediate filaments.

1995 • 30 citations

Identification of a conserved phosphorylation site modulating nuclear lamin polymerization

1997 • 29 citations

The developmentally regulated Drosophila embryonic nuclear lamina protein ‘Young Arrest’ (fs(1)Ya) is capable of associating with chromatin

1997 • 29 citations

Aspects of the evolution of the lamin/intermediate filament protein family: a current analysis of invertebrate intermediate filament proteins

1991 • 28 citations

Charge interactions in the rod domain drive formation of tetramers during intermediate filament assembly

1994 • 28 citations

cDNA Cloning of Nuclear Localization Signal Binding Protein NBP60, a Rat Homologue of Lamin B Receptor, and Identification of Binding Sites of Human Lamin B Receptor for Nuclear Localization Signals and Chromatin

1997 • 26 citations

Epidermolysis Bullosa Simplex

1998 • 24 citations

PERIODIC REPEAT UNITS OF EPITHELIAL CELL TONOFILAMENTS

1967 • 22 citations

New Algorithms for the Computation of Evolutionary Phylogenetic Trees

1994 • 20 citations

IDENTIFICATION OF THE ANTIGEN RECOGNIZED BY THE MONOCLONAL ANTIBODY BU31 AS LAMINS A AND C

1996 • 20 citations

Transfection of human lamins A and C into mouse embryonal carcinoma cells possessing only lamin B

1990 • 20 citations

Nuclear Pore Complex Structure in Birds

1997 • 20 citations

Chemical crosslinking with disuccinimidyl tartrate defines the relative positions of the two antiparallel coiled coils of the desmin protofilament unit

1993 • 13 citations