The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation.

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

A MODIFIED PROCEDURE FOR LEAD STAINING OF THIN SECTIONS

1961 • 1,388 citations

The nuclear lamina is a meshwork of intermediate-type filaments

1986 • 957 citations

Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

1986 • 836 citations

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.

1986 • 711 citations

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses

1991 • 647 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Epidermolysis Bullosa Simplex: Evidence in Two Families for Keratin Gene Abnormalities

1991 • 426 citations

The lattice spacing of crystalline catalase as an internal standard of length in electron microscopy

1968 • 426 citations

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering

1992 • 406 citations

Neurofilaments are obligate heteropolymers in vivo

1993 • 387 citations

Mutations in the Rod Domains of Keratins 1 and 10 in Epidermolytic Hyperkeratosis

1992 • 370 citations

The genetic basis of epidermolytic hyperkeratosis: A disorder of differentiation-specific epidermal keratin genes

1992 • 339 citations

Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments

1983 • 336 citations

The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins

1983 • 326 citations

The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins

1982 • 298 citations

Intermediate filament structure

1992 • 297 citations

Self-assembly in vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments

1981 • 288 citations

A leucine→proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

1992 • 284 citations

Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments

1993 • 270 citations

Keratin Intermediate Filament Structure

1993 • 260 citations

Elucidating the early stages of keratin filament assembly.

1990 • 243 citations

Proteinchemical characterization of three structurally distinct domains along the protofilament unit of desmin 10 nm filaments

1982 • 242 citations

The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines.

1987 • 237 citations

Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing

1988 • 230 citations

Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoproteins.

1991 • 224 citations

The fibrillar substructure of keratin filaments unraveled.

1983 • 219 citations

Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments.

1989 • 210 citations

Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M

1993 • 203 citations

Purification of individual components of the neurofilament triplet: filament assembly from the 70000-dalton subunit

1982 • 201 citations

Structure of intermediate filaments

1983 • 195 citations

Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cells

1984 • 194 citations

Intermediate filament forming ability of desmin derivatives lacking either the amino-terminal 67 or the carboxy-terminal 27 residues

1985 • 193 citations

Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe.

1985 • 188 citations

Intermediate filament structure: 3. Analysis of sequence homologies

1988 • 178 citations

Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions.

1991 • 176 citations

Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit.

1990 • 173 citations

Identification of a nonapeptide motif in the vimentin head domain involved in intermediate filament assembly

1992 • 164 citations

Assembly of vimentin in vitro and its implications concerning the structure of intermediate filaments

1985 • 154 citations

Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations.

1992 • 152 citations

Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro.

1990 • 135 citations

Of mice and men: Genetic skin diseases of keratin

1992 • 135 citations

Antiparallel orientation of the two double-stranded coiled-coils in the tetrameric protofilament unit of intermediate filaments

1985 • 131 citations

The role of the head and tail domain in lamin structure and assembly: Analysis of bacterially expressed chicken Lamin A and truncated B2 lamins

1992 • 130 citations

The coiled-coil molecules of intermediate filaments consist of two parallel chains in exact axial register

1985 • 129 citations

A glow discharge unit to render electron microscope grids and other surfaces hydrophilic

1987 • 127 citations

The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro.

1992 • 127 citations

A periodic ultrastructure in intermediate filaments

1982 • 126 citations

Unifying principles in intermediate filament (IF) structure and assembly

1988 • 124 citations

Molecular biology of neuronal intermediate filaments

1993 • 123 citations

Characterization of dimer subunits of intermediate filament proteins

1986 • 119 citations

Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.

1990 • 116 citations

Intermediate filaments formed de novo from tail-less cytokeratins in the cytoplasm and in the nucleus.

1991 • 114 citations

Modulation of keratin intermediate filament assembly by single amino acid exchanges in the consensus sequence at the C-terminal end of the rod domain

1991 • 109 citations

Expression in escherichia coli of human lamins A and C: influence of head and tail domains on assembly properties and paracrystal formation

1991 • 109 citations

The cellular and molecular biology of keratins: beginning a new era

1993 • 107 citations

Visualization of a 21-nm axial periodicity in shadowed keratin filaments and neurofilaments.

1982 • 100 citations

The conserved H1 domain of the type II keratin 1 chain plays an essential role in the alignment of nearest neighbor molecules in mouse and human keratin 1/keratin 10 intermediate filaments at the two- to four-molecule level of structure.

1993 • 99 citations

Chemical cross‐linking indicates a staggered and antiparallel protofilament of desmin intermediate filaments and characterizes one higher‐level complex between protofilaments

1992 • 95 citations

Study of the 10-nm-filament fraction isolated during the standard microtubule preparation

1980 • 93 citations

The complete amino acid sequence of the major mammalian neurofilament protein (NF‐L)

1985 • 93 citations

Assembly of amino-terminally deleted desmin in vimentin-free cells.

1990 • 91 citations

The effects of dephosphorylation on the structure of the projections of neurofilament

1989 • 90 citations

Polymorphism of reconstituted human epidermal keratin filaments: Determination of their mass-per-length and width by scanning transmission electron microscopy (STEM)

1985 • 88 citations

Periodic charge distribution in the intermediate filament proteins desmin and vimentin

1982 • 76 citations

Assembly of a tail-less mutant of the intermediate filament protein, vimentin, in vitro and in vivo.

1992 • 74 citations

Analysis of the mechanism of assembly of mouse keratin 1/keratin 10 intermediate filaments in vitro suggests that intermediate filaments are built from multiple oligomeric units rather than a unique tetrameric building block

1991 • 73 citations

The roles of the rod end and the tail in vimentin IF assembly and IF network formation

1993 • 72 citations

Molecular architecture of the neurofilament

1990 • 68 citations

Preparation of single molecules and supramolecular complexes for high-resolution metal shadowing

1983 • 68 citations

Conservation of the structure of keratin intermediate filaments: Molecular mechanism by which different keratin molecules integrate into preexisting keratin intermediate filaments during differentiation

1993 • 67 citations

Organization of coiled-coil molecules in native mouse keratin 1/keratin 10 intermediate filaments: Evidence for alternating rows of antiparallel in-register and antiparallel staggered molecules

1991 • 66 citations

Effect of aluminum and other multivalent cations on neurofilaments in vitro: An electron microscopic study

1990 • 65 citations

Tailless keratins assemble into regular intermediate filaments in vitro

1990 • 62 citations

In vitro reconstitution of recombinant lamin A and a lamin A mutant lacking the carboxy-terminal tail.

1991 • 58 citations

A potential role for the COOH-terminal domain in the lateral packing of type III intermediate filaments.

1991 • 58 citations

Assembly of carboxy-terminally deleted desmin in vimentin-free cells.

1991 • 57 citations

Interference in vimentin assembly in vitro by synthetic peptides derived from the vimentin head domain

1992 • 51 citations

Effects of truncated neurofilament proteins on the endogenous intermediate filaments in transfected fibroblasts

1991 • 50 citations

Reconstitution of cytokeratin filaments in vitro: further evidence for the role of nonhelical peptides in filament assembly.

1984 • 49 citations

Human Epidermal Keratin Filaments: Studies on Their Structure and Assembly^a

1985 • 48 citations

Molecular architecture of the neurofilament

1990 • 45 citations

Properties of the desmin tail domain: studies using synthetic peptides and antipeptide antibodies.

1990 • 41 citations

Modulation of desmin intermediate filament assembly by a monoclonal antibody.

1988 • 34 citations

The two coiled coils in the isolated rod domain of the intermediate filament protein desmin are staggered

1990 • 34 citations

Macromolecular structure of reassembled neurofilaments as revealed by the quick-freeze deep-etch mica method: difference between NF-M and NF-H subunits in their ability to form cross-bridges.

1992 • 33 citations

Chemical crosslinking with disuccinimidyl tartrate defines the relative positions of the two antiparallel coiled coils of the desmin protofilament unit

1993 • 13 citations

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