Caspase-2 function in response to DNA damage

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Cell death by mitotic catastrophe: a molecular definition

2004 • 1,201 citations

The protein structures that shape caspase activity, specificity, activation and inhibition

2004 • 844 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

2004 • 654 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

2002 • 511 citations

Compromised HOXA5 function can limit p53 expression in human breast tumours

2000 • 466 citations

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis

2002 • 421 citations

Direct coupling of the cell cycle and cell death machinery by E2F

2002 • 419 citations

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

2000 • 379 citations

Caspases: their intracellular localization and translocation during apoptosis

1999 • 358 citations

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

1998 • 350 citations

Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid

2000 • 346 citations

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy

2004 • 289 citations

The biochemical mechanism of caspase-2 activation

2004 • 201 citations

Caspase-2 Can Trigger Cytochrome c Release and Apoptosis from the Nucleus

2002 • 184 citations

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

2004 • 183 citations

Catalytic properties of the caspases

1999 • 178 citations

Salmonella-Induced Caspase-2 Activation in Macrophages

2000 • 174 citations

A novel Apaf-1–independent putative caspase-2 activation complex

2002 • 165 citations

Prodomain-dependent Nuclear Localization of the Caspase-2 (Nedd2) Precursor

1998 • 157 citations

Bid-Cardiolipin Interaction at Mitochondrial Contact Site Contributes to Mitochondrial Cristae Reorganization and CytochromecRelease

2004 • 157 citations

Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins

2001 • 149 citations

Death in the Balance: Alternative Participation of the Caspase-2 and -9 Pathways in Neuronal Death Induced by Nerve Growth Factor Deprivation

2001 • 149 citations

Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells

2003 • 149 citations

Caspase 2 and Caspase 3 Protein Levels as Predictors of Survival in Acute Myelogenous Leukemia

1998 • 148 citations

The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development

2005 • 146 citations

Caspase-1 Activates Nuclear Factor of the κ-Enhancer in B Cells Independently of Its Enzymatic Activity

2004 • 136 citations

HOXA5-Induced Apoptosis in Breast Cancer Cells Is Mediated by Caspases 2 and 8

2003 • 134 citations

Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity

2004 • 125 citations

HIV induces lymphocyte apoptosis by a p53‐initiated, mitochondrial‐mediated mechanism

2000 • 116 citations

Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids

2004 • 115 citations

STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7

2004 • 112 citations

Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway

2003 • 106 citations

Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

2004 • 95 citations

Caspases are not localized in mitochondria during life or death

2002 • 80 citations

Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death

2002 • 79 citations

Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.

1999 • 77 citations

Loss of caspase‐2, ‐6 and ‐7 expression in gastric cancers

2004 • 73 citations

Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

2001 • 70 citations

A Novel Caspase-2 Complex Containing TRAF2 and RIP1

2004 • 69 citations

Loss of caspase-2, -6 and -7 expression in gastric cancers

2004 • 64 citations

Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD

2000 • 62 citations

alphaII-Spectrin is an in vitro target for caspase-2, and its cleavage is regulated by calmodulin binding

2004 • 62 citations

Caspase‐2 activation is redundant during seizure‐induced neuronal death

2001 • 46 citations

Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria

2003 • 45 citations

A Key Role for Caspase-2 and Caspase-3 in the Apoptosis Induced by 2-Chloro-2′-deoxy-adenosine (Cladribine) and 2-Chloro-adenosine in Human Astrocytoma Cells

2003 • 45 citations

p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner

2001 • 41 citations

Overexpression of the Anti-Apoptotic Caspase-2 Short Isoform in Macrophage-Derived Foam Cells of Human Atherosclerotic Plaques

2003 • 36 citations

Activation of Caspase-2 Mediates the Apoptosis Induced by GTP-Depletion in Insulin-Secreting (HIT-T15) Cells*

2002 • 35 citations

Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB

2004 • 34 citations

Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells

2002 • 32 citations

Characterization of a Novel Proapoptotic Caspase-2- and Caspase-9-binding Protein

2001 • 29 citations

Chromosomal Localization of the Human Genes,CPP32, Mch2, Mch3,andIch-1,Involved in Cellular Apoptosis

1996 • 25 citations

Epstein‐Barr virus‐encoded latent membrane protein 1 promotes stress‐induced apoptosis upstream of caspase‐2‐dependent mitochondrial perturbation

2004 • 24 citations

Endogenous and exogenous ARC in serum withdrawal mediated PC12 cell apoptosis: a new pro-apoptotic role for ARC

2001 • 23 citations

Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain

2004 • 12 citations