Chimaerins, Novel Non-protein Kinase C Phorbol Ester Receptors, Associate with Tmp21-I (p23)

Experiments in molecular genetics

1972 • 28,260 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Regulation of protein kinase C

1997 • 919 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Localized Rac Activation Dynamics Visualized in Living Cells

2000 • 667 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 584 citations

Correlation of Two-Hybrid Affinity Data with In Vitro Measurements

1995 • 536 citations

Rho GTPases

1998 • 534 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

1999 • 315 citations

Rho Proteins: Linking Signaling with Membrane Trafficking

2001 • 274 citations

Protein kinase C binding partners

2000 • 264 citations

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

1996 • 252 citations

The Coatomer Protein β′-COP, a Selective Binding Protein (RACK) for Protein Kinase Cε

1997 • 251 citations

Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts.

1996 • 243 citations

The atypical protein kinase Cs

2000 • 217 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells

2000 • 200 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 194 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

2000 • 165 citations

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis

1995 • 149 citations

Involvement of the Transmembrane Protein p23 in Biosynthetic Protein Transport

1997 • 143 citations

Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.

1995 • 133 citations

PKCε, Via its Regulatory Domain and Independently of its Catalytic Domain, Induces Neurite-like Processes in Neuroblastoma Cells

1999 • 122 citations

Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration.

1994 • 116 citations

Intracellular localization and in vivo trafficking of p24A and p23

1999 • 105 citations

Endocytosis and signaling cascades: a close encounter

2001 • 105 citations

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.

1993 • 104 citations

β2-Chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain

1999 • 99 citations

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

1993 • 95 citations

β2-Chimaerin Is a High Affinity Receptor for the Phorbol Ester Tumor Promoters

1997 • 95 citations

The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity.

1996 • 85 citations

Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors.

1994 • 81 citations

p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory pathway

1997 • 81 citations

A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.

1994 • 77 citations

Fgd1, the Cdc42 guanine nucleotide exchange factor responsible for faciogenital dysplasia, is localized to the subcortical actin cytoskeleton and Golgi membrane

2001 • 76 citations

Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.

1994 • 75 citations

Rac1 is required for cell proliferation and G2/M progression

1997 • 73 citations

The transmembrane protein p23 contributes to the organization of the Golgi apparatus

2000 • 68 citations

Phorbol Esters and Related Analogs Regulate the Subcellular Localization of β2-Chimaerin, a Non-protein Kinase C Phorbol Ester Receptor

2001 • 68 citations

Human munc13 Is a Diacylglycerol Receptor that Induces Apoptosis and May Contribute to Renal Cell Injury in Hyperglycemia

1999 • 40 citations

Calphostin C induces selective disassembly of the Golgi complex by a protein kinase C-independent mechanism

1998 • 12 citations