Phosphorothioate oligodeoxynucleotides—anti-sense inhibitors of gene expression?

Adhesion receptors of the immune system

1990 • 6,585 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

NUCLEOSIDE PHOSPHOROTHIOATES

1985 • 830 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Gene Synthesis Machines: DNA Chemistry and Its Uses

1985 • 761 citations

Molecular Analysis of the T(14;18) Chromosomal Translocation in Malignant Lymphomas

1987 • 701 citations

Adhesion molecules controlling lymphocyte migration

1989 • 654 citations

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

1988 • 617 citations

Physicochemical properties of phospborothioate oligodeoxynucleotides

1988 • 567 citations

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

1991 • 551 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

1991 • 468 citations

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

1988 • 467 citations

Oligodeoxynucleotides as inhibitors of gene expression: a review.

1988 • 419 citations

Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties

1990 • 400 citations

Regulation of Gene Expression with Double-Stranded Phosphorothioate Oligonucleotides

1990 • 373 citations

Modified deoxyoligonucleotides stable to exonuclease degradation in serum

1991 • 356 citations

Synthesis of DNA via deoxynudeoside H-phosphonate Intermediates

1986 • 343 citations

Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides.

1990 • 299 citations

3H-1,2-Benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonucleoside phosphorothioates

1990 • 296 citations

Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture.

1989 • 296 citations

Bond Order and Charge Localization in Nucleoside Phosphorothioates

1985 • 277 citations

Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides

1984 • 272 citations

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

1989 • 264 citations

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1989 • 238 citations

Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

1988 • 227 citations

DNA and RNA Sequence Determination Based on Phosphorothioate Chemistry

1988 • 226 citations

Oligonucleotide analogues as potential chemotherapeutic agents.

1988 • 221 citations

Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

1989 • 207 citations

Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide

1989 • 190 citations

Site-specific excision from RNA by RNase H and mixed-phosphate-backbone oligodeoxynucleotides.

1990 • 177 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

1987 • 173 citations

Mouse Mos protooncogene product is present and functions during oogenesis.

1989 • 173 citations

Phosphorothioates in molecular biology

1989 • 173 citations

RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

1989 • 169 citations

Synthesis and configurational analysis of a dinucleoside phosphate isotopically chiral at phosphorus. Stereochemical course of Penicillium citrinum nuclease P1 reaction

1983 • 162 citations

Synthesis of ribonucleosides and diribonucleoside phosphates containing 2-chloro-ethylamine and nitrogen mustard residues.

1967 • 160 citations

Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site

1984 • 158 citations

The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos

1990 • 156 citations

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cells

1989 • 147 citations

Internucleotide phosphite sulfurization with tetraethylthiuram disulfide. Phosphorothioate oligonucleotide synthesis via phosphoramidite chemistry

1991 • 145 citations

Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism

1991 • 144 citations

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates)

1991 • 142 citations

Stereochemical course of the reaction catalyzed by 5'-nucleotide phosphodiesterase from snake venom

1979 • 141 citations

Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications.

1991 • 140 citations

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

1990 • 140 citations

Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element

1991 • 133 citations

Techniques for using antisense oligodeoxyribonucleotides to study gene expression

1988 • 130 citations

Oligodeoxynucleotides: Antisense inhibitors of gene expression

1990 • 124 citations

Phosphorothioate and normal oligodeoxyribonucleotides with 5′-linked acridine: characterization and preliminary kinetics of cellular uptake

1988 • 123 citations

Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.

1989 • 118 citations

Reversed-phase high-performance liquid chromatographic separation of diastereomeric phosphorothioate analogues of oligodeoxyribonucleotides and other backbone-modified congeners of dna

1985 • 114 citations

Stereochemistry of hydrolysis by snake venom phosphodiesterase.

1979 • 105 citations

Delivery of c-myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Correlates with Inhibition of Cell Growth and DNA Synthesis

1988 • 102 citations

Synthesis and properties of dithymidine phosphate analogues containing 3′-thiothymidine

1990 • 102 citations

Inhibition of human immunodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives

1989 • 98 citations

Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides

1990 • 87 citations

Effect of Phosphorothioate Homo-oligodeoxy nucleotides on Herpes Simplex Virus Type 2-induced DNA Polymerase

1989 • 85 citations

Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition

1985 • 83 citations

Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4.

1991 • 83 citations

Mode of action of 5'-linked cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro

1991 • 82 citations

Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscoptc studies of theR_p-R_p,S_p-S_p, andR_p-S_pduplexes, [d(GG_sAATTCC)]₂, derived from diastereomericO-ethyl phosphorothioates

1986 • 80 citations

Inhibition of influenza virus replication by phosphorothioate oligodeoxynucleotides.

1990 • 78 citations

Phosphoroselenoate oligodeoxynucleotides: synthesis, physico-chemical characterization, anti-sense inhibitory properties and anti-HIV activity

1989 • 73 citations

Ribonucleases H of retroviral and cellular origin

1990 • 72 citations

A potential role for antisense oligonucleotide analogues in the development of oncogene targeted cancer chemotherapy.

1990 • 69 citations

Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV)

1988 • 68 citations

A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression).

1987 • 68 citations

Phosphorothioate Oligodeoxynucleotides Are Potent Sequence Nonspecific Inhibitors of De Novo Infection by HIV

1989 • 63 citations

Phosphorothioate oligonucleotides: chemistry, purification, analysis, scale-up and future directions.

1991 • 62 citations

Synthetic repeating sequence DNAs containing plsosphorothioates: nuclease sensitivity and triplex formation

1989 • 61 citations

Stereochemical course of DNA hydrolysis by nuclease S1.

1983 • 57 citations

Sulfur does not form double bonds in phosphorothioate anions

1987 • 55 citations

Crystal and Molecular Structure of Adenosine 5'-O-Phosphorothioate O-p-Nitrophenyl Ester (Sp Diastereomer). Substrate Stereospecificity of Snake Venom Phosphodiesterase

1979 • 48 citations

High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids

1990 • 47 citations

Oligodeoxynucleotide analogs with 5′‐linked anthraquinone

1989 • 44 citations

Synthesis and selective cleavage of an oligodeoxynucleotide containing a bridged intemucleotide 5′-phosphorothioate linkage

1991 • 42 citations

Phosphorothioate Oligodeoxynucleotide Analogues

1989 • 38 citations

Antisense agents in pharmacology

1990 • 37 citations

Preparation of 35S-labeled polyphosphorothioate oligodeoxyribonucleotides by use of hydrogen phosphonate chemistry

1990 • 33 citations

"Post-assay" covalent labeling of phosphorothioate-containing nucleic acids with multiple fluorescent markers

1989 • 33 citations

Phosphorus-oxygen bond order in adenosine 5'-O-phosphorothioate dianion

1984 • 31 citations

Comparative inhibition of ras p21 protein synthesis with phosphorus-modified antisense oligonucleotides.

1989 • 30 citations

Hybridization and dissociation rates of phosphodiester or modified oligodeoxynucleotides with RNA at nearphysiological conditions.

1991 • 29 citations

Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.

1990 • 27 citations

Effects of oligo sequence and chemistry on the efficiency of oligodeoxyribonucleotide-mediated mRNA cleavage

1990 • 25 citations

Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents

1990 • 24 citations

Phospholipids chiral at phosphorus: Fourier-transform infrared study on the gel-liquid crystalline transition of chiral thiophosphatidylcholine

1986 • 18 citations

Anti-sense oligonucleotides as potential antitumour agents: prospective views and preliminary results.

1988 • 14 citations

Effect of Evans Blue and Trypan Blue on Syncytia Formation and Infectivity of Human Immunodeficiency Virus Type I and Type II In Vitro

1991 • 12 citations

Stereochemistry of organophosphorus cyclic compounds. Part IV. Synthesis and geometrical isomerism in cyclic five-membered phosphorus thioacids. Crystal and molecular structure of the imidazolium salt of r-2-hydroxy-c-4-methyl-1,3,2-dioxaphospholan-2-thione

1976 • 9 citations

Antisense oligonucleotide derivatives as gene-targeted drugs.

1990 • 6 citations

Antisense oligonucleotide derivatives as gene-targeted drugs.

1990 • 5 citations