Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

Synthesis of deoxyoligonucleotides on a polymer support

1981 • 870 citations

Polymer support oligonucleotide synthesis XVIII^1.2): use ofβ-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

1984 • 840 citations

Gene Synthesis Machines: DNA Chemistry and Its Uses

1985 • 761 citations

Automated Synthesis of Peptides

1965 • 516 citations

An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides

1983 • 504 citations

2-Cyanoethyl Phosphate and its Use in the Synthesis of Phosphate Esters¹

1961 • 443 citations

Studies on Polynucleotides. XXIV.¹ The Stepwise Synthesis of Specific Deoxyribopolynucleotides (4).² Protected Derivatives of Deoxyribonucleosides and New Syntheses of Deoxyribonucleoside-3″ Phosphates³

1963 • 397 citations

Transient protection: efficient one-flask syntheses of protected deoxynucleosides

1982 • 385 citations

The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

1987 • 367 citations

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides

1987 • 356 citations

Synthesis of DNA via deoxynudeoside H-phosphonate Intermediates

1986 • 343 citations

The chemical synthesis of oligo- and poly-nucleotides by the phosphotriester approach

1978 • 310 citations

Studies on Polynucleotides. XIV.¹ Specific Synthesis of the C_3″-C_5″ Interribonucleotide Linkage. Syntheses of Uridylyl-(3″→5″)-Uridine and Uridylyl-(3″→5″)-Adenosine²

1962 • 280 citations

Synthesis of thymidine oligonucleotides by phosphite triester intermediates

1976 • 277 citations

β-Cyanoethyl N,N-dialkylamino/N-morpholinomonochloro phosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized oligonucleotides

1983 • 266 citations

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

1990 • 262 citations

SYNTHESIS AND USE OF SYNTHETIC OLIGONUCLEOTIDES

1984 • 260 citations

In situactivation of bis-dialkylaminophosphines—a new method for synthesizing deoxyoligonucleotides on polymer supports

1984 • 241 citations

The synthesis of oligoribonucleotides. II. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VII

1978 • 239 citations

Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides¹

1977 • 235 citations

Kinetics and mechanism of the acid-catalyzed hydrolysis of some purine nucleosides

1970 • 228 citations

Hindered dialkylamino nucleoside phosphite reagents in the synthesis of two DNA 51-mers

1983 • 227 citations

Solid phase synthesis of polynucleotides. VI. Farther studies on polystyrene copolymers for the solid support

1982 • 219 citations

Studies of Siloxane Phases Bonded to Silica Gel for Use in High Performance Liquid Chromatography

1974 • 207 citations

The p-nitrophenylethyl (NPE) group

1984 • 201 citations

Oligonucleotide Synthesis on a Polymer Support^1,2

1965 • 198 citations

The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups

1987 • 197 citations

Oximate ion promoted unblocking of oligonucleotide phosphotriester intermediates

1978 • 197 citations

CIII. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast

1972 • 197 citations

New catalysts and procedures for the dimethoxytritylation and selective silylation of ribonucleosides

1982 • 196 citations

Total Synthesis of a Gene

1979 • 192 citations

Storage stability of water-insoluble enzymes covalently coupled to organic and inorganic carriers

1970 • 191 citations

The tert-Butyldimethylsilyl Group as a Protecting Group in Deoxynucleosides

1973 • 186 citations

Rapid synthesis of oligodeoxyribonucleotides VI. Effident, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route

1981 • 185 citations

Nucleoside h-phosphonates: Valuable intermediates in the synthesis of deoxyoligonucleotides

1986 • 182 citations

A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: segmental solid supports

1983 • 181 citations

Nucleotide chemistry. 16. Amidine protecting groups for oligonucleotide synthesis

1986 • 181 citations

The allylic protection method in solid-phase oligonucleotide synthesis. An efficient preparation of solid-anchored DNA oligomers

1990 • 179 citations

Chemical synthesis of oligonucleotides

1977 • 173 citations

CIV. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Chemical synthesis of an icosadeoxynucleotide corresponding to the nucleotide sequence 21 to 40

1972 • 173 citations

Automated Synthesis of Gene Fragments

1981 • 171 citations

Nucleoside H-phosphonates. III. Chemical synthesis of oligodeoxyribonucleotides by the hydrogenphosphonate approach

1986 • 166 citations

4-(1,2,4-Triazol-1-yl)- and 4-(3-nitro-1,2,4-triazol-1-yl)-1-(β-<scp>D</scp>-2,3,5-tri-O-acetylarabinofuranosyl)pyrimidin-2(1H)-ones. Valuable intermediates in the synthesis of derivatives of 1-(β-<scp>D</scp>-arabinofuranosyl)cytosine (ara-C)

1982 • 158 citations

Nucleotides part XXXII. Synthesis of a dithymidine dinucleotide containing a 3′: 5′-internucleotidic linkage

1955 • 151 citations

Nucleic acid synthesis

1968 • 151 citations

Nucleotide chemistry. XX. Phosphite coupling procedure for generating internucleotide links

1975 • 146 citations

Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activity.

1988 • 144 citations

Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability

1986 • 133 citations

Deoxynucleoside H-Phosphonate diester intermediates in the synthesis of internucleotide phosphate analogues

1986 • 132 citations

Synthesis of oligodeoxyribonucleotides on silica gel support

1981 • 130 citations

Rapid synthesis of oligodeoxyribonucleotides IV. Improved solid phase synthesis of oligodeoxy-ribonucleotides through phosphotriester intermediates

1980 • 129 citations

The synthesis of oligodeoxyprimidines on a polymer support

1980 • 129 citations

Reaction between 1-arenesulphonyl-3-nitro-1,2,4-triazoles and nucleoside base residues. Elucidation of the nature of side-reactions during oligonucleotide synthesis.

1980 • 127 citations

Synthesis of the 3'-terminal decaribonucleoside nonaphosphate of yeast alanine transfer ribonucleic acid

1980 • 126 citations

Design of RNA enzymes distinguishing a single base mutation in RNA

1989 • 126 citations

Chemical Methods of Oligonucleotide Synthesis

1975 • 125 citations

The Synthesis of oligoribonucleotides—IV

1968 • 125 citations

Allyloxycarbonyl group: a versatile blocking group for nucleotide synthesis

1986 • 124 citations

Syringe method for stepwise chemical synthesis of oligonucleotides

1982 • 123 citations

Dialkylformamldines: depurination resistant N⁶-protecting group for deoxyadenosine

1983 • 123 citations

Nucleotide chemistry. XIII. Synthesis of oligothymidylates via phosphotriester intermediates

1969 • 122 citations

A convenient and general approach to the synthesis of properly protected d-nucleoside-3′-hydrogenphosphonates via phosphite intermediates

1986 • 116 citations

Some Observations Relating to Acyl Mobility in Aminoacyl Soluble Ribonucleic Acids^*

1966 • 114 citations

Synthesis of functionally tethered oligodeoxynucleotides by the convertible nucleoside approach

1990 • 114 citations

Synthesis of oligonucleotides on cellulose by a phosphotriester method

1980 • 113 citations

Cleavage of specific sites of RNA by designed ribozymes

1988 • 113 citations

Construction of a series of several self‐cleaving RNA duplexes using synthetic 21‐mers

1988 • 112 citations

Nonaqueous oxidation of nucleoside phosphites to the phosphates

1986 • 112 citations

An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis

1990 • 110 citations

Improved triester approach for the synthesis of pentadecathymidylic acid

1975 • 110 citations

Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction.

1976 • 109 citations

Efficient methods for attachment of thiol specific probes to the 3′-ends of synthetic oligodeoxyribonucleotides

1987 • 109 citations

The use of silyl groups in protecting the hydroxyl functions of ribonucleosides

1974 • 108 citations

Symmetrical alternative to the tetrahydropyranyl protecting group

1967 • 101 citations

Hybridization triggered cross-linking of deoxyoligonucleotides

1986 • 101 citations

Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotide derivatives

1991 • 101 citations

Nucleoside H-phosphonates. IV. Automated solid phase synthesis of oligoribonucleotides by the hydrogenphosphonate approach

1986 • 99 citations

Engineering tethered DNA molecules by the convertible nucleoside approach

1991 • 97 citations

The triphenylmethyl (trityl) group and its uses in nucleotide chemistry

1980 • 97 citations

DNA synthesis

1983 • 95 citations

The synthesis of oligoribonucleotides. III. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VIII

1979 • 95 citations

Prevention of chain cleavage in the chemical synthesis of 2′-silylated oligoribonucleotides

1989 • 94 citations

Synthesis, catalytic activity, and behavior of phase-transfer catalysts supported on silica gel. Strong influence of substrate adsorption on the polar polymeric matrix on the efficiency of the immobilized phosphonium salts

1979 • 94 citations

Chemical Synthesis and Biological Studies on Mutated Gene-control Regions

1983 • 89 citations

Stepwise Synthesis of Oligodeoxyribonucleotides on an Insoluble Polymer Support^1,2

1966 • 89 citations

Synthesis and characterization of dinucleoside phosphorodithioates

1988 • 88 citations

Studies on Polynucleotides. IX.¹ Experiments on the Polymerization of Mononucleotides. Certain Protected Derivatives of Deoxycytidine-5' Phosphate and the Synthesis of Deoxycytidine Polynucleotides²

1961 • 88 citations

Solid-phase synthesis and high-resolution NMR studies of two synthetic double-helical RNA dodecamers: r(CGCGAAUUCGCG) and r(CGCGUAUACGCG)

1989 • 85 citations

The 9-phenylxanthen-9-yl protecting group

1978 • 85 citations

Chemical synthesis of a tridecanucleoside dodecaphosphate sequence of SV40 DNA

1980 • 85 citations

Application of 2-cyanoethyl N,N,N′,N′-tetraisopropylphosphorodiamidite forin situpreparation of deoxyribonucleoside phosphoramidites and their use in polymer-supported synthesis of oligodeoxyribonucleotides

1986 • 84 citations

Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition

1985 • 83 citations

Synthesis of 4-(1,2,4-triazol-1-yl)-pyrimidin-2(1H)-one ribonucleotide and its application in synthesis of oligoribonucleotides

1982 • 82 citations

[61] Chemical synthesis of deoxyoligonucleotides by the modified triester method

1980 • 82 citations

Improvements in the phosphoramidite procedure for the synthesis of oligodeoxyribonucleotides

1983 • 81 citations

Convenient method for stepwise synthesis of oligothymidylate derivatives in large-scale quantities

1967 • 81 citations

Substituted 5-phenyltetrazoles: improved activators of deoxynucleoside phosphoramidites in deoxyoligonucleotide synthesis.

1983 • 81 citations

Mechanistic studies on the phosphoramidite coupling reaction in oligonucleotide synthesis. I. Evidence for nudeophilic catalysis by tetrazole and rate variations with the phosphorus substituents

1987 • 80 citations

Synthesis of oligodeoxyribonucleotides using N-(benzyloxycarbonyl)-blocked nucleosides

1982 • 80 citations

Synthesis of oligodeoxynucleotides and oligodeoxynucleotide analogs using phosphoramidite intermediates

1984 • 79 citations

Selective protection of hydroxyl groups in deoxynucleosides using alkylsilyl reagents.

1974 • 79 citations

The protection of thymine and guanine residues in oligodeoxyribonucleotide synthesis

1984 • 79 citations

Rapid synthesis of long-chain deoxyribooligonucleotides by the N-methylimidazolide phosphotriester method

1983 • 78 citations

Preparation of N-dimethylaminomethylene derivatives - A new method of a selective substitution of nucleoside amino groups

1967 • 78 citations

CV. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Chemical synthesis of an icosadeoxyribonucleotide corresponding to the nucleotide sequence 31 to 50

1972 • 77 citations

Synthesis of a dodecaribonucleotide, GUAUCAAUAAUG, by use of "fully" protected ribonucleotide building blocks

1984 • 74 citations

4-methoxytetrahydropyran-4-yl

1970 • 73 citations

The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosides

1980 • 73 citations

Chemical conversion of thymidine into 5-methyl-2′-deoxycytidine

1981 • 73 citations

Use of the -butyldimethylsilyl group for protecting the hydroxyl functions of nucleosides

1973 • 72 citations

Fast oligonucleotide deprotection phosphoramidite chemistry for DNA synthesis

1990 • 72 citations

Studies on the role of tetrazole in the activation of phosphoramidites

1989 • 72 citations

Contribution to the mechanism of the acid-catalyzed hydrolysis of purine nucleosides

1972 • 71 citations

The protection of uracil and guanine residues in oligonucleotide synthesis

1981 • 71 citations

Recent developments in the chemical synthesis of polynucleotides

1982 • 71 citations

A new strategy for the protection of deoxyguanosine during oligonucleotide synthesis

1982 • 70 citations

Hydrolysis of Esters of Monoribonucleotides

1956 • 70 citations

Studies on the t-butyldimethylsilyl group as 2'-O-protection in oligoribonucleotide synthesis via the H-phosphonate approach

1988 • 69 citations

644. Nucleotides. Part XLI. Mixed anhydrides as intermediates in the synthesis of dinucleoside phosphates

1957 • 69 citations

Nitrate ion as catalyst for selective silylations of nucleosides

1981 • 68 citations

Action of acid on oligoribonucleotide phosphotriester intermediates. Effect of released vicinal hydroxy functions

1985 • 67 citations

Synthesis of deoxynucleoside methylphosphonates via a phosphonamidite approach

1984 • 67 citations

Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex

1990 • 66 citations

Migration of t-butyldimethylsilyl protecting groups

1979 • 66 citations

The synthesis of polyamide-oligonucleotide conjugate molecules

1990 • 65 citations

[8] Chemical synthesis and cloning of a tyrosine tRNA gene

1979 • 64 citations

The organic chemistry underlying DNA synthesis

1986 • 64 citations

New synthetic routes to synthons suitable for 2′-O-allyloligoribonucleotide assembly

1991 • 64 citations

Synthesis of oligonucleotides via monomers with unprotected bases

1991 • 63 citations

Bifunctional oligonucleotide probes synthesized using a novel CPG support are able to detect single base pair mutations

1989 • 63 citations

Synthesis of 4-triazolopyrimidinone nucleotide and its application in synthesis of 5-methylcytosine-containing oligodeoxyribonucleotides

1981 • 63 citations

Synthesis of benzyl and benzyloxycarbonyl base-blocked 2'-deoxyribonucleosides

1982 • 63 citations

New, ionic side-products in oligonucleotide synthesis: formation and reactivity of fluorescent N-/purin-6-yl/pyridinium salts¹

1985 • 62 citations

Derivatization of controlled pore glass beads for solid phase oligonucleotide synthesis.

1988 • 62 citations

Stereochemical studies of the formation of chiral internucleotide linkages by phosphoramidite coupling in the synthesis of oligodeoxyribonucleotides

1984 • 62 citations

General method for the preparation of N3- and O4-substituted uridine derivatives by phase-transfer reactions

1989 • 62 citations

New guanosine derivatives: facile O6-phosphorylation, thiophosphinylation sulfonylation and silylation of guanosine derivatives by 4-dimethylaminopyridine catalized reaction

1980 • 61 citations

Methylphosphonates as probes of protein-nucleic acid interactions

1984 • 61 citations

Acid-catalysed isomerization of the tetraisopropyldisiloxane-1,3-diyl group. Simultaneous protection of two secondary alcoholic functions.

1980 • 61 citations

A new and versatile approach to the preparation of valuable deoxynucleoside 3′-phosphite intermediates

1986 • 61 citations

Synthesis of dinucleoside monophosphorothioates via addition of sulphur to phosphite triesters.

1978 • 60 citations

N-acyl protecting groups for deoxynucleosides

1981 • 60 citations

An acetal group suitable for the protection of 2′-hydroxy functions in rapid oligoribonucleotide synthesis

1986 • 60 citations

Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethorycarbunyl (Fmoc) for 5′-hydroryl protection

1989 • 60 citations

Acyl migration in ribonucleoside derivatives

1965 • 60 citations

Dialkyl aluminium chloride: a reagent for removal of trityl group from trityl ethers of deoxynucleosides, deoxynucleotides, and oligodeoxynucleotides

1982 • 59 citations

Recovery and recycling of synthetic units in the construction of oligodeoxyribonucleotides on solid supports

1981 • 59 citations

[16] An automated DNA synthesizer employing deoxynucleoside 3′-phosphoramidites

1987 • 59 citations

The use of labile base protecting groups in oligoribonucleotide synthesis

1989 • 59 citations

Synthesis of DNA fragments by the hydroxybenzotriazole phosphotriester approach

1984 • 58 citations

A new base-stable linker for solid-phase oligonucleotide synthesis

1989 • 57 citations

Modification of guanine bases by nucleoside phosphoramidite reagents during the solid phase synthesis of oligonucleotides

1985 • 57 citations

Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2′-hydroxyl via a phosphite triester approach

1986 • 57 citations

Facile removal of new base protecting groups useful in oligonucleotide synthesis

1987 • 57 citations

Improved synthesis of oligodeoxynucleotides on controlled pore glass using phosphotriesther chemistry and a flow system

1983 • 57 citations

High yield selective 3′-silylation of ribonucleosides

1981 • 56 citations

Diphenylcarbamoyl and propionyl groups: a new combination of protecting groups for the guanine residue

1983 • 56 citations

Polymer support oligonucleotide synthesis-XV

1984 • 56 citations

Some developments in the phosphitetriester method for synthesis of oligonucleotides

1984 • 56 citations

Improved synthesis of oligodeoxyribonucleotides

1990 • 56 citations

The solid phase synthesis of oligonucleotides containing a 3′-peptide moiety

1987 • 56 citations

Studies on transfer ribonucleic acids and related compounds. IX⁽¹⁾Ribo-oligonucleotide synthesis using a photosensitive o-nitrobenzyl protection at the 2′-hydroxyl group

1974 • 56 citations

5'-Levulinyl and 2'-tetrahydrofuranyl protection for the synthesis of oligoribonucleotides by the phosphoramidite approach

1988 • 56 citations

Guanine modification daring chemical DNA synthesis

1987 • 55 citations

Synthesis and applications of oligoribonucleotides with selected 2′-O-methylation using the 2′-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl] protecting group

1990 • 55 citations

A new type of silyl protecting groups in nucleoside chemistry

1978 • 55 citations

Oligonucleotide synthesis. Part 21. Synthesis of ribooligonucleotides using the 4-methoxybenzyl group as a new protecting group for the 2'-hydroxyl group

1984 • 54 citations

Synthesis and characterization of oligodeoxynucleotides containing 4-O-methylthymine

1987 • 54 citations

Novel activating and capping reagents for improved hydrogen-phosphonate DNA synthesis

1988 • 53 citations

Nucleoside 3'-phosphotriesters as key intermediates for the oligoribonucleotide synthesis. IV. New method for removal of 2,2,2-trichioroethyl group and³¹NMR as a new tool for analysis of deblocking of intemucleotide phosphate protecting groups

1977 • 52 citations

Studies on the structure and stabilizing factor of the CUUCGG hairpin RNA using chemically synthesized oligonucleotides

1990 • 52 citations

Synthesis of -6-alkylated deoxyguanosine nucleosides

1982 • 52 citations

Synthesis of well-defined phosphate-methylated DNA fragments: the application of potassium carbonate in methanol as deprotecting reagent

1990 • 51 citations

The chemical synthesis of oligoribonucleotides. IX. A comparison of protecting groups in the dichloridite procedure

1980 • 51 citations

Synthesis of phosphate-methylated DNA fragments using 9-fluorenylmethoxycarbonyl as transient base protecting group

1989 • 51 citations

Assignment of resonances in the phosphorus-31 NMR spectrum of d(GGAATTCC) by regiospecific labeling with oxygen-17

1984 • 50 citations

Solid phase synthesis of oligoribonucleotides using the o-nitrobenzyl group for 2'-hydroxyl protection and H-phosphonate chemistry

1987 • 49 citations

Oligoribonucleotide synthesis 2′,5′-protected ribonucleoside derivatives

1964 • 49 citations

Synthesis of short oligoribonucleotides bearing a 3'- or 5'-terminal phosphate by use of 4,4',4"-tris(4,5-dichlorophthalimido)trityl as a new 5'-hydroxyl protecting group

1986 • 48 citations

Selective N-deacylation of N,O-protected nucleosides by zinc bromide

1981 • 48 citations

The preparation of polyamide-oligonucleotide probes containing multiple non-radioactive labels

1990 • 48 citations

[6] Improved phosphotriester method for the synthesis of gene fragments

1979 • 47 citations

Phthaloyl group : a new amino protecting group of deoxyadenosine in oligonucleotide synthesis

1982 • 47 citations

The flouren-9-ylmethoxycarbonyl group for the protection of hydroxy-groups; its application in the synthesis of an octathymidylic acid fragment

1982 • 47 citations

Use of trichlorodimethylethyl as a protecting group and tributylphosphine as a deprotecting agent in oligonucleotide synthesis

1982 • 47 citations

Silica gel as solid support in the synthesis of oligoribonucleotides

1980 • 47 citations

Nucleotide chemistry. XIV. Protecting groups for nucleosides used in synthesizing oligonucleotides

1969 • 46 citations

Synthesis of deoxyguanylyldeoxyguanosine on an insoluble polymer support

1968 • 46 citations

Synthesis of 6-substituted 2′-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine

1990 • 46 citations

Reactions of Nucleosides on Polymer Supports. Synthesis of Thymidylylthymidylylthymidine^*

1967 • 46 citations

Methoxyethoxymethyl group for the protection of uracil residue in oligoribonucleotide synthesis

1983 • 45 citations

Removal of copper and iron prior to water hardness titration

1976 • 45 citations

Solid phase synthesis of the 5′-half of the initiator t-RNA fromB.subtilis

1989 • 44 citations

New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives

1986 • 44 citations

Synthesis of O6-p-nitrophenylethyl guanosine and 2′-deoxyguanosine derivatives

1983 • 44 citations

Synthesis and Properties of O6-Substituted Guanosine Derivatives

1981 • 44 citations

Reactions of dimethylformamide acetals with some heterocyclic systems

1963 • 44 citations

A simple and efficient preparation of deoxynucleoside phosphoramidites in situ

1984 • 44 citations

Preparation of ribonucleoside 3′-O-phosphoramidites and their application to the automated solid phase synthesis of oligonucleotides

1985 • 44 citations

Solid phase synthesis of oligoribonucleotides using the l-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2′-hydroxy functions and the H-phosphonate approach

1989 • 43 citations

Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives

1986 • 43 citations

Selective 2′-benzoylation at the 2′, 3′-diols of protected ribonucleosides. New solid phase synthesis of RNA and DNA-RNA mixtures

1982 • 43 citations

Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis

1983 • 43 citations

Modified phosphotriester method for chemical synthesis of ribooligonucleotides. Part I. Synthesis of riboundecaadenylate and two fragments constituting the sequence of R-17 translation control signal

1982 • 42 citations

Analytical studies of ‘mixed sequence’ oligodeoxyribonucleotides synthesized by competitive coupling of either methyl- or β-cyanoethyl-N,N-diisopropylamino phosphoramidite reagents, including 2′-deoxyinosine

1985 • 42 citations

Polymer supported DNA synthesis using hydroxybenzotriazole activated pbosphotriester intermediates

1984 • 42 citations

A new synthesis of 1-arylpiperidin-4-ols

1988 • 42 citations

Phosphotriester approach to oligothymidylate synthesis utilizing a simple thymidine unit and a new type of condensing agents

1981 • 42 citations

Isomerization of tert-butyldimethylsilyl protecting groups in ribonucleosides

1981 • 41 citations

Methylation of thymine residues during oligonucleotide synthesis

1985 • 41 citations

A universal solid support for the synthesis of 3′-thiol group containing oligonucleotides

1990 • 41 citations

Improvements in oligodeoxyribonucleotide synthesis: methyl N,N-dialkylphosphoramidite dimer units for solid support phosphite methodology

1984 • 41 citations

Kinetics and mechanism of the hydrolysis of guanosine and 7-methylquanosine nucleosides in perchloric acid

1972 • 40 citations

Allyl protection of internucleotide linkage

1985 • 40 citations

Chemical Synthesis of Capped Oligoribonucleotides, m⁷G^5′pppAUG and m⁷G^5′pppAUGACC

1985 • 40 citations

Acylation of 2′,3′,5′-tri-O-acetylguanosine

1977 • 40 citations

N6(N-methyl-2-pyrrolidine amidine)deoxyadenosine - a new deoxynucleoside protecting group

1983 • 39 citations

Improved synthesis of (Pr₂¹N)₂POCH₂CH₂CN

1987 • 39 citations

The reaction of 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane with cytosine arabinoside and 1-(6-deoxy-α-L-talofuranosyl)uracil

1980 • 39 citations

Use of 2-methylsulfonylethyl as a phosphorus protecting group in oligonucleotide synthesis via a phosphite triester approach

1984 • 39 citations

New improvements in oligonucleotide synthesis by use of the p-nitrophenylethyl phosphate blocking group and its deprotection by DBU or DBN

1980 • 39 citations

2′(3′)- -benzoyluridine 5′ linked to glass: an all-purpose support for solid phase synthesis of oligodeoxyribonucleotides

1983 • 39 citations

The use of barium salts of protected deoxyribonudeoside-3′ p-chlorophenyl phosphates for construction of oligonucleotides by the phosphotriester method: high-yield synthesis of dinucleotide blocks

1979 • 38 citations

Solid-phase synthesis of modified oligodeoxyribonucleotides with an acridine derivative or a thiophosphate group at their 3′end

1989 • 38 citations

Synthesis and structure assignments of amide protected nucleosides and their use as phosphoramidites in deoxyoligonucleotide synthesis

1988 • 37 citations

Nonaqueous oxidation of phosphites to phosphates in nucleotide synthesis

1981 • 37 citations

Synthesis in the study of nucleic acids. The Fourth Jubilee Lecture

1968 • 37 citations

The methyl group as phosphate protecting group in nucleotide syntheses

1980 • 37 citations

A new type of protection mode for the Guanine residue by using 1,2-diisobutyryloxyethylene group

1982 • 37 citations

The effect of protecting groups of the nucleobase and the sugar moieties on the acidic hydrolysis of the glycosidic bond of 2deoxyadenosine: a kinet

1987 • 37 citations

Synthesis and NMR study of ribooligonucleotides forming a hammerhead-type RNA enzyme system

1990 • 37 citations

Secondary deuterium isotope effects for acid-catalyzed hydrolysis of inosine adenosine

1978 • 36 citations

SYNTHESIS OF OLIGORIBONUCLEOTIDES USING 4-METHOXYBENZYL GROUP AS A NEW PROTECTING GROUP OF THE 2′-HYDROXYL GROUP OF ADENOSINE

1982 • 36 citations

Chemical Synthesis of a Pentaribonucleoside Tetraphosphate Constituting the 3'-Acceptor Stem Sequence of E. coli tRNAIle Using 2'-O-(3-Methoxy-1,5-dicarbomethoxypentan-3-yl)-ribonucleoside Building Blocks. Application of a New Achiral and Acid-labile 2'-Hydroxyl Protecting Group in tRNA Synthesis.

1985 • 36 citations

Protonation de l'adénine, de la purine et de l'adénosine en milieu acide fort

1984 • 36 citations

Solid phase synthesis of the 3′-terminal nonadecaribonucleoside octadecaphosphate sequence of yeast alanine transfer ribonucleic acid

1987 • 35 citations

Synthesis of oligoribonucleotides by use of S,S-diphenyl n-monomethoxytrityl ribonucleoside 3'-phosphorodithioates

1984 • 35 citations

New Approach to the Synthesis of Deoxyribonucleoside Phosphoramidite Derivatives

1986 • 35 citations

A NEW PROTECTING TACTICS FOR THE URACIL RESIDUE IN OLIGORIBONUCLEOTIDE SYNTHESIS

1983 • 35 citations

Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides

1986 • 35 citations

The isopropoxyacetic group for convenient base protection during solid-support synthesis of oligodeoxyribonucleotides and their triester analogs

1989 • 34 citations

[13] Simultaneous synthesis and biological applications of DNA fragments: An efficient and complete methodology

1987 • 34 citations

Polymer support oligonucleotide synthesis VI use of inorganic carriers

1972 • 34 citations

Enhanced coupling efficiency using 4-dimethylaminopyridine (DMAP) and either tetrazole, 5-(-nitrophenyl) tetrazole, or 5-(-nitrophenyl) tetrazole in the solid phase synthesis of oligoribonucleotides by the phosphoramidite procedure.

1987 • 34 citations

Solution synthesis of fully protected thymidine dimers using various phosphoramidites

1984 • 34 citations

Filter disc supported oligonucleotide synthesis by the phosphite method

1984 • 34 citations

Cylci diacyl groups for protection of the N⁶-amino group of deoxyadenosine in oligodeoxynucleotide synthesis

1984 • 33 citations

New solid-phase for automated synthesis of oligonucleotides containing an amino-alkyl linker at their 3′-end

1990 • 33 citations

Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH₂: a nucleopeptide fragment from the nucleoprotein of bacteriophage øX174

1990 • 33 citations

3-N-Acyl Uridines: Preparation and Properties of a New Class of Uracil Protecting Group.

1983 • 33 citations

Synthesis of mixed oligodeoxyribonucleotides following the solid phase method

1982 • 33 citations

Improved procedure for the preparation of deoxynucleoside phosphoramidites: Arylphosphoramidites as new convenient intermediates for oligodeoxynucleotide synthesis

1984 • 33 citations

The synthesis of oligoribonucleotides VI. The synthesis of a hexadecamer by a block condensation approach

1980 • 33 citations

A versatile solid phase method for the synthesis of oligonucleotide-3′-phosphates

1991 • 32 citations

A new and general procedure for the preparation of deoxynucleoside phosphoramidites

1983 • 32 citations

High-yield synthesis of oligoribonucleotides using -nitrobenzyl protection of 2′-hydroxyls

1985 • 32 citations

Oxygen chiral phosphate in uridylyl(3'.fwdarw.5')adenosine by oxidation of a phosphite intermediate: synthesis and absolute configuration

1983 • 31 citations

A new linkage for solid phase synthesis of oligodeoxyribonucleotides

1985 • 31 citations

The preparation of protected arabinonucleosides

1983 • 30 citations

Facile synthesis and phosphorus-31 NMR spectra of a double-labeled oligonucleotide d(Ap(17O)Gp(18O)Cp(16O)T)

1984 • 30 citations

Solid-phase assembly of cow colostrum trypsin inhibitor gene

1987 • 30 citations

Stereo- and regiochemistries of the oxidations of 2-methoxy-5-tert-butyl-1,3,2-dioxaphosphorinanes and the cyclic methyl 3',5'-phosphite of thymidine by water/iodine and oxygen/AIBN to P-chiral phosphates. Oxygen-17 NMR assignment of phosphorus configuration to the diastereomeric thymidine cyclic methyl 3',5'-monophosphates

1989 • 30 citations

Acidic hydrolysis of 6-substituted 9-(2-deoxy-β--- pentofuranosyl) purines and their 9-(1-alkoxyethyl) counter-parts: kinetics and mechanism.1

1987 • 29 citations

Reaction between nucleoside base residues and the phosphorylating agent derived from 1-hydroxybenzotriazole and 2-chloroprenyl phosphorodichloridate

1985 • 29 citations

Selective deprotection by reductive cleavage with radical anions

1975 • 29 citations

The 2'-Hydroxyl Function Assisted Cleavage of the Internucleotide Phosphotriester Bond of a Ribonucleotide Under Acidic Conditions.

1985 • 29 citations

Silylated derivatives of arabinonucleosides

1982 • 29 citations

Deoxyoligonucleotide synthesis via the phosphoramidite method.

1983 • 29 citations

N-Phenoxyacetylated guanosine and adenosine phosphoramidites in the solid phase synthesis of oligoribonucleotides: Synthesis of a ribozyme sequence

1988 • 29 citations

Site-specific modification of the pyrimidine residue during the deprotection of the fully-protected diuridylic acid

1986 • 29 citations

The practical synthesis of RNA fragments in the solid phase approach

1988 • 29 citations

Synthesis of oligoribonucleotides with sequences identical to the nucleation region of Tobacco Mosaic Virus RNA: Preparation of AAG, AAGAAG and AAGAAGUUG via phosphotriester methods

1981 • 28 citations

Universal solid supports for the synthesis of oligonucleotides with terminal 3′-phosphates

1989 • 28 citations

Conversion of guanosine into its N 2-methyl derivative

1977 • 28 citations

The 2-(acetoxymethyl)benzoyl (AMB) group as a new base-protecting group, designed for the protection of (phosphate) modified oligonucleotides.

1990 • 28 citations

Synthesis of DNA fragments containing 5,6-dihydrothymine, a major product of thymine gamma radiolysis

1988 • 28 citations

Chemical synthesis of the 24 RNA fragments corresponding to hop stunt viroid

1989 • 27 citations

Thymidine nucleoside 3′,5′-cyclic phosphoramidites and phosphites. Configuration at phosphorus in trivalent and pentavalent cyclic nucleotides by 31P and 13C nmr.

1978 • 27 citations

Automated chloridite and amidite synthesis of oligodeoxyribonucleotides on a long chain support using amidine protected purine nucleosides

1989 • 27 citations

One pot RP-diastereoselective synthesis of dinucleoside methylphosphonates using methyldichlorophosphine

1989 • 27 citations

Conceptual basis of the selective activation of bis(dialkylamino)methoxyphosphines by weak acids and its application toward the preparation of deoxynucleoside phosphoramidites in situ

1985 • 27 citations

Depurination As a Yield Decreasing Mechanism in Oligodeoxynucleotide Synthesis

1985 • 27 citations

A Universal Glass Support for Oligonucleotide Synthesis

1987 • 27 citations

The synthesis of 2′–5′ linked oligoribonucleotides

1979 • 26 citations

N-levulination of nucleosides

1982 • 26 citations

The protection of 2′-hydroxy functions in oligoribonucleotide synthesis

1984 • 26 citations

The p-Nitrophenylethyl Group - An Universal Blocking Group in Nucleoside and Nucleotide Chemistry

1985 • 26 citations

PROTECTION OF IMIDE GROUP OF URACIL MOIETY BY MEANS OF 2,2,2-TRICHLORO-TERT-BUTYLOXYCARBONYL CHLORIDE: A SELECTIVE SYNTHESIS OF 2′-O-METHYLURIDINE

1982 • 25 citations

4,4',4''-Tris(benzoyloxy)trityl as a new type of base-labile group for protection of primary hydroxyl groups

1983 • 25 citations

Two new protected acyl protecting groups for alcoholic hydroxy functions

1984 • 25 citations

The effect of spacer, linkage and solid support on the synthesis of oligonucleotides

1989 • 25 citations

Use of 2‐cyano‐1,1‐dimethylethyl as a protecting group in the synthesis of DNA VIA phosphite intermediates

1984 • 25 citations

Deoxyribonucleoside 3′-phosphordiamidites as substrates for solidsupported synthesis of oligodeoxyribonucleotides and their phosphorothioate and dna-triester analogues

1987 • 25 citations

A convenient method for the formation of internucleotide linkage

1984 • 24 citations

The synthesis of phosphite analogues of ribonucleotides

1980 • 24 citations

The synthesis of oligoribonucleotides V. The stepwise synthesis of the 3′-terminal heptanucleotide sequence of tRNA^fMet from E. coli

1979 • 24 citations

Enzymatic and NMR analysis of oligoribonucleotides synthesized with 2′-tert-butyldimethylsilyl protected cyanoethlphosphoramidite monomers

1990 • 24 citations

Rapid syntheses of protected 2'-deoxycytidine derivatives

1980 • 24 citations

Nucleoside, IV¹⁾ Über die Tritylierung und Benzylierung von Adenosin‐Derivaten

1970 • 24 citations

2-mercaptobenzothiazole--an improved reagent for the removal of methyl phosphate protecting groups from oligodeoxynucleotide phosphotriesters.

1988 • 24 citations

Introduction of the 4,4′4′-tris(benzoyloxy)trityl group into the exo amino groups of deoxyribonucleosides and its properties

1985 • 24 citations

The 9-(4-Octadecyloxyphenylxanthen)-9-yl-Group. A new Acid-labile Hydroxyl Protective Group and Its Application in the Preparative Reverse-phase Chromatographic Separation of Oligoribonucleotides.

1984 • 23 citations

Polysytyrene-supported synthesis by the phosphite triester approach: An alternative for the large scale synthesis of small oligodeoxyribonucleotides.

1990 • 23 citations

Studies on transfer ribonucleic acids and related compounds. XLV. Block condensation of ribooligonucleotides containing 2' -O-tetrahydrofuranyl-5' -O-dimethoxytritylnucleosides

1983 • 23 citations

Studies on transfer ribonucleic acids and related compounds. XLIV. A large-scale synthesis of the anticodon heptanucleotide of formyl-methionine transfer ribonucleic acid by using 2'-O-tetrahydrofuranylnucleosides.

1983 • 23 citations

Phosphoramidate analogues of diribonucleoside monophosphates

1980 • 23 citations

Pyridyl Groups for Protection of the Imide Functions of Uridine and Guanosine. Exploration of Their Displacement Reactions for Site-specific Modifications of Uracil and Guanine Bases.

1986 • 23 citations

A stereospeifically¹⁸O-labelled deoxydinucleoside phosphate block for incorporation into an oligonucleotide

1983 • 23 citations

A new method for the synthesis of branched oligoribonucleotides using a fully protected branched triribonucleoside diphosphate unit

1987 • 22 citations

Introduction of a nonaqueous oxidation procedure in the phosphite triester route for oligonucleotide synthesis

1985 • 22 citations

Large scale synthesis of oligoribonucleotides on a solid support: synthesis of a catalytic RNA duplex

1990 • 22 citations

Aminoacyl derivatives of nucleosides, nucleotides and polynucleotides. 43. New approach to synthesis of 2'(3')-O-aminoacyl oligoribonucleotides

1987 • 22 citations

Oligonucleotidic compounds. XXXIII. A study on hydrolysis of N-dimethylaminomethylenecytidine, -adenosine, -guanosine, and related 2'-deoxy compounds

1969 • 22 citations

A convenient method for removal of the t-butyl group from nucleoside bis(t-butyl) phosphates under non-acidic conditions

1991 • 22 citations

Synthesis of oligonucleotides containing a carboxyl group at either their 5′ end or their 3′ end and their subsequent derivatization by an intercalating agent

1990 • 22 citations

Synthesis of the 3′-terminal half of yeast alanine transfer ribonucleic acid (tRNA^Ala) by the phosphotriester approach in solution. Part 2

1989 • 22 citations

Synthesis of O4-p-nitrophenylethyl thymidine and uridine derivatives

1983 • 21 citations

Improved 3'-O-phosphorylation of guanosine derivatives by O6-oxygen protection

1982 • 21 citations

Studies on Nucleotide Chemistry 15. Synthesis of Oligodeoxynucleotides Using Amidine Protected Nucleosides

1985 • 21 citations

Polymer Support Oligonucleotide Synthesis XX: Synthesis of a Henhectacosa Deoxynucleotide by Use of a Dimeric Phosphoramidite Synthon

1986 • 21 citations

A new protected acyl protecting group for exocyclic amino functions of nucleobases

1990 • 21 citations

A novel route for solid phase synthesis of polynucleotides using phosphite chemistry

1983 • 21 citations

Modifications of guanine bases during oligonucleotide synthesis

1988 • 21 citations

A simple preparation of 5′-o-dimethoxytrityl deoxyribonucleoside 3′-o-phosphorbisdiethylamidites as useful intermediates in the synthesis of oligodeoxyribonucleotides and their phosphorodiethylamidate analogs on a solid support

1989 • 21 citations

A new method for the synthesis of branched ribonucleotides

1987 • 21 citations

Facile nucleoside phoshorylation via hydroxyl activation

1983 • 21 citations

An improved syringe technique for the preparation of oligonucleotides of defined sequence

1983 • 21 citations

Chemical synthesis of a messenger RNA fragment: AUGUUCUUCUUCUUCUUC

1982 • 21 citations

On the Application of t-Butyldimethylsilyl Group in Chemical RNA Synthesis. Part I.³¹P NMR Study of 2′-O-t-BDMSi Group Migration During Nucleoside 3′-OH Phosphorylation and Phosphitylation Reactions

1989 • 21 citations

Automatic Synthesis of Oligodeoxynucleotides and Mixed Oligodeoxynucleotides using the Phosphoamidite Method.

1984 • 21 citations

The 9-Fluorenylmethoxycarbonyl (Fmoc) Group for the Protection of Amino Functions of Cytidine, Adenosine, Guanosine and Their 2'-Deoxysugar Derivatives.

1983 • 21 citations

Synthesis of the 3′-terminal half of yeast alanine transfer ribonucleic acid (tRNA^Ala) by the phosphotriester approach in solution. Part 1. Preparation of the nucleoside building blocks

1989 • 21 citations

Phosphotriester synthesis of DNA fragments on cellulose and polystyrene solid supports

1982 • 21 citations

BIS-(N,N-DIALKYLAMINO)-ALKOXYPHOSPHINES AS A NEW CLASS OF PHOSPHITE COUPLING AGENT FOR THE SYNTHESIS OF OLIGONUCLEOTIDES

1984 • 21 citations

New intermediates for the synthesis of oligonucleotides by the phosphite triester approach

1981 • 20 citations

Mechanism of Nucleophilic Substitution at Tricovalent Phosphorus

1983 • 20 citations

An Improved Method for the Synthesis ofN ³-Benzoylthymidine

1987 • 20 citations

One-step protection of the nucleoside base in thymidine and uridine

1985 • 20 citations

The Problem of 2′-Protection in Rapid Oligoribonucleotide Synthesis

1987 • 20 citations

Synthesis of 5′-O-phosphonomethyl-2′,3′-didehydro-2′,3′-dideoxyuridine by use of P-methoxybenzyl as a N3-protecting group.

1991 • 20 citations

Synthesis of 5'-O-phosphonomethyl derivatives of pyrimidine 2'-deoxynucleosides

1990 • 20 citations

Solution synthesis of protected di-2′-deoxynucleoside phosphotriesters via the phosphoramidite approach

1984 • 19 citations

Synthesis of C-5 and N-3 Arenesulfenyl Uridines. Preparation and Properties of a New Class of Uracil Protecting Group.

1985 • 19 citations

A study on the alkylsilyl groups in oligoribonucleotide synthesis

1990 • 19 citations

Chemical synthesis of DNA

1989 • 19 citations

Polymer support synthesis

1987 • 19 citations

1-(2-Chloroethoxy)ethyl group for the protection of 2′-hydroxyl group in the synthesis of oligoribonucleotides

1989 • 19 citations

Further development of oligoribonucleotide:bis(tributyltin)oxide as a reagent for removal of the internucleotidic phenylthio group via the phosphotriester approach

1986 • 19 citations

Synthesis of oltgonucleotides with sequences identical with or analogous to the 3′-end of 16S ribosomal RNA of Es cherichia coli: preparation of m⁶₂A-C-C-U-C-C and A-C-C-U-C-m⁴₂C via phosphotriester intermediates¹

1977 • 19 citations

Nucleosides and Nucleotides. Part 17. A simple preparation of protected deoxynucleoside‐3'‐phosphates

1981 • 19 citations

A General Approach to the Chemical Synthesis of Oligodeoxyribonucleotides.

1981 • 18 citations

Solid-phase synthesis of oligodeoxyribonucleotides using the bis(trimethylsilyl) peroxide oxidation of phosphites

1986 • 18 citations

The steriochemical course of iodine–water oxidation of dinucleoside phosphite triesters

1984 • 18 citations

The reaction of Tetrazole with Phosphoramidites as a Model for the Nucleotide Coupling Step

1988 • 18 citations

Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

1990 • 18 citations

Base Modification and the Phosphoramidite Approach

1987 • 18 citations

Synthesis of 2'-O-(1,3-benzodithiol-2-yl)uridine and related compounds as key intermediates in oligoribonucleotide synthesis

1983 • 18 citations

Der 2-Trichlormethyl-2-propyl — Rest als Phosphatschutz in der Oligonukleotidsynthese / The 2-Trichloromethyl-2-propyl Group as a Protecting Group in Oligonucleotide Synthesis

1984 • 18 citations

Polymer‐supported synthesis of deoxyoligonucleotides using in‐situ prepared deoxynucleoside 2‐cyanoethyl phosphoramidites

1986 • 18 citations

USE OF 3,4-DIMETHOXYBENZYL GROUP AS A PROTECTING GROUP FOR THE 2′-HYDROXYL GROUP IN THE SYNTHESIS OF OLIGORIBONUCLEOTIDES

1986 • 18 citations

Oligonucleotide synthesis. Part 34. (Methoxyethoxy)methyl group: new amide and hydroxyl protecting groups of uridine in oligonucleotide synthesis

1986 • 18 citations

Necessary protection of the O6-position of guanine during the solid phase synthesis of oligonucleotides by the phosphoramidite approach

1985 • 18 citations

Triphenylmethanesulfenyl Group. A New Protecting Group for the Uracil Residue in Oligoribonucleotide Synthesis

1988 • 17 citations

ATTEMPTED SYNTHESIS OF TRIMESITYLPHOSPHAETHENE; OBSERVATIONS RELATED TO THE MECHANISM OF ACID CATALYZED NUCLEOPHILIC SUBSTITUTIONS AT PHOSPHORUS (III)

1984 • 17 citations

Naphthaloyl group: a new selective amino protecting group for deoxynucleosides in oligonucleotide synthesis

1988 • 17 citations

Studies on transfer ribonucleic acids and related compounds. XLIII. Synthesis of oligoribonucleotides by using 5'-selective phosphorylation of 2'-O-tetrahydrofuranyl nucleosides.

1983 • 17 citations

p-Methoxybenzyl as a NewN³-Imide Protecting Group of 5-Fluorouridine and Its Application to the Synthesis of 5′-O-Acryloyl-5-fluorouridine

1990 • 17 citations

7-Deaza-2′-Deoxy-O⁶-Methylguanosine: Selective N²-Formylation Via a Formamidine, Phosphoramidite Synthesis and Properties of Oligonucleotides

1989 • 17 citations

Solid phase synthesis of oligoribonucleotides using -nitrobenzyl protection of 2'-hydroxyl via a phosphotriester approach

1988 • 17 citations

Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides. 45. Synthesis of 2'(3')-O-(aminoacyl) trinucleotides incorporating all four common bases

1988 • 17 citations

A Convenient Preparation of N-Protected Nucleosides with the 2,2,2-Trichloro-t-butyloxycarbonyl (TCBOC) Group. Structural Assignment of N,N-bis-TCBOC Guanoside and Its 2'-Deoxy Analogue.

1985 • 17 citations

1,1-Bis-(4- ethoxyphenyl)-1′-pyrenyl ethyl (bmpm): a new fluorescent 5′ protecting group for the purification of unmodified and modified oligonucleotides

1987 • 17 citations

Stereochemistry of oxidation of diastereoisomeric d(TpA) phosphonates with sulphur and iodine–[¹⁸O]water

1990 • 16 citations

Chemical synthesis of the 5half molecule of E.coli tRNA2GLY

1984 • 16 citations

Die 2,2,2-trichlor-t-butyloxycarbonyl-gruppe, eine neue n-schutzgruppe für oligonucleotidsynthesen

1983 • 16 citations

[[2-(Methylthio)phenyl]thio]methyl (MTPM): a new protecting group of hydroxyl groups capable of conversion to a methyl group

1989 • 16 citations

New methods in peptide synthesis, based on supernucleophiles

1979 • 16 citations

Use of 1,1,1,3,3,3-hexafluoro-2-propyl protecting group in the synthesis of dna fragments via phosphoramidite intermediates

1988 • 16 citations

A new condensing reagent, 1-(2,4,6-triisopropylbenzenesulfonyl)-5-(pyridin-2-yl)tetrazolide and its use in the synthesis of λ cro binding heptadecanucleotide on a polymer support

1982 • 16 citations

Some Aspects of the Chemical Synthesis of Oligoribonucleotides

1985 • 16 citations

Aminoacyl derivatives of nucleosides, nucleotides, polynucleotides. 46. General synthesis of 2'(3')-O-aminoacyl oligoribonucleotides. The protection of the guanine moiety

1989 • 16 citations

The 9‐fluorenylmethyloxycarbonyl group as a 5′‐OH protection in oligonucleotide synthesis

1989 • 16 citations

3-(Imidazol-1-ylmethyl)-4',4"-dimethoxytrityl: a new functionalized 5'-hydroxyl protecting group capable of rapid internucleotidic bond formation in the phosphorothio ester approach

1987 • 15 citations

SELECTIVE REMOVAL OF TERMINAL DIMETHOXYTRITYL GROUPS

1983 • 15 citations

Convenient procedure for the preparation of specific mixed DNA-RNA polymers

1989 • 15 citations

Synthesis of adenylyl-(2′→5′)-adenylyl-(2′→5′)-adenosine (2-5A core)

1980 • 15 citations

Improved chemistry for oligodeoxyribonucleotide synthesis substantially improves restriction enzyme cleavage of a synthetic 35mer

1989 • 15 citations

Structural assignment of n3-acylated uridine derivatives by means of 13c nmr spectroscopy

1984 • 15 citations

Preparation and Properties of Chloro-N, N-dialkylamino-2,2,2-trichloroethoxy- and Chloro-N, N-dialkylamino-2,2,2-trichloro-1,1-dimethylethoxyphosphines and their Deoxynucleoside Phosphiteamidates

1985 • 15 citations

The chemical synthesis of oligoribonucleotides VII. A comparison of condensing agents in the coupling of silybted ribonucleosides

1980 • 15 citations

Synthesis of 2'- or 3'-o-(4-methoxybenzyl)nucleosides and its application in the 3'-terminal nonanucleotide sequence of rous sarcoma virus 35S RNA synthesis

1986 • 15 citations

An Improved Procedure for the Protection of 2′-Deoxyguanosine

1986 • 15 citations

Large scale bench-top synthesis of a nineteen unit ribonucleotide on silica gel.

1984 • 15 citations

O-aryl phosphoramidites: synthesis, reactivity and evaluation of their use for solid-phase synthesis of oligonucleotides

1990 • 15 citations

Preparation and phosphorylation reactivity of -nonacylated nucleoside phosphoramidites

1985 • 15 citations

Nucleotides. Part XXXIVSynthesis of Modified Oligomeric 2′–5′A Analogues: Potential Antiviral Agents

1991 • 15 citations

The reaction of 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane with some open chain polyhydroxy compounds

1980 • 14 citations

Solid-supported synthesis, deprotection and enzymatic purification of oligodeoxyribonucleotides

1986 • 14 citations

Chemoselective phosphorylation of -unprotected nucleosides via aluminum alkoxides

1983 • 14 citations

4,4',4"-Tris(4,5-dichlorophthalimido)trityl: a new type of hydrazine-labile group as a protecting group of primary alcohols

1984 • 14 citations

A rapid and efficient synthesis of ribonucleotides

1978 • 14 citations

The 2-Nitrophenylsulfenyl (Nps) Group for the Protection of Amino Functions of Cytidine, Adenosine, Guanosine and Their 2'-Deoxysugar Derivatives.

1983 • 14 citations

Synthesis of uridine oligonucleotide by the reaction of unprotected uridine with tri-(imidazolyl-(1))phosphine

1980 • 14 citations

A simple and convenient synthesis of 3′-5′- or 2′-5′-linked oligoribonucleotide by polymerization of unprotected ribonucleoside using phosphorus tris-azole

1984 • 14 citations

Improved Synthesis of Oligodeoxyribonucleotides by Solid‐Phase Phosphotriester Method Utilizing O⁶‐[2‐(p‐Nitrophenyl)ethyl]‐2′‐deoxyguanosine Derivatives

1984 • 14 citations

DNA Synthesis for Nonchemists: The Phosphoramidite Method on Silica Supports

1987 • 14 citations

Solid Phase Synthesis of DNA Under a Non-Depurinating Condition with a Base Labile 5′-Protecting Group (Fmoc) Using Phosphiteamidite Approach

1987 • 14 citations

The Preparation of Deoxyguanosine Oligomers on an Insoluble Polymer Support

1971 • 13 citations

Improved synthesis of oligodeoxyribonucleotide using 3-methoxy-4-phenoxybenzoyl group for amino protection

1986 • 13 citations

FURTHER IMPROVEMENTS OF OLIGODEOXYRIBONUCLEOTIDES SYNTHESIS: SYNTHESIS OF TETRADEOXYADENYLATE ON A NEW SILICA GEL SUPPORT USING N6-PHTHALOYLDEOXYADENOSINE

1983 • 13 citations

Use of the naphthalene radical ion in deblocking O-methoxytrityl nucleotide derivatives

1975 • 13 citations

Modification of guanine bases: reaction of N2-acylated guanine nucleosides with dichloro-(N,N-diisopropylamino)phosphine

1986 • 13 citations

NEW TYPE OF PREFABRICATED FULLY PROTECTED RIBONUCLEOTIDE MONOMER UNITS AS USEFUL SYNTHETIC INTERMEDIATES IN RAPID OLIGORIBONUCLEOTIDE SYNTHESIS

1982 • 13 citations

Developments in the chemical synthesis of naturally occurring DNA and RNA sequences with normal and unusual linkages

1987 • 13 citations

Purification orientated synthesis of oligodeoxynucleotides in solution

1983 • 13 citations

The 9-Fluorenylmethyloxycarbonyl (Fmoc) Group as a 5′-O Base Labile Protecting Group in Solid Supported Oligonucleotide Synthesis

1987 • 12 citations

PURINES, PYRIMIDINES, NUCLEOSIDES, AND NUCLEOTIDES: PHYSICAL CONSTANTS AND SPECTRAL PROPERTIES

2010 • 12 citations

Solid‐phase synthesis of the RNA fragment: rAAGAAGAAGAAGA

1982 • 12 citations

Studies on Chemical Synthesis of mRNAs. I. Synthesis and Properties ofN²-Tritylguanosine Derivatives and Application to Synthesis of pGpUpU

1982 • 12 citations

An effective method for the preparation of O6 -substituted guanosine and n3-substituted uridine derivatives via the corresponding stannylated intermediates

1986 • 12 citations

Some Aspects of the Reaction of Arenesulfenyl chlorides with Hydroxyl Functions of Ribonucleosides.

1985 • 12 citations

A convenient route to adenine N1-oxide mono- and polynucleotides by oxidation with potassium monopersulfate

1989 • 12 citations

4,4′,4″-Tris(levulinoyloxy)trityl as a New Type of Primary Hydroxyl Protecting Group

1985 • 11 citations

The Chemical Synthesis of Oligo- and Poly-ribonucleotides

1989 • 11 citations

Double Protection of the Heterocyclic Base of Xanthosine and 2′-Deoxyxanthosine

1989 • 11 citations

A new solid-phase synthesis of oligoribonudeotides by the pbosphoro-p-anisidate method using tetrahydrofuranyl protection of 2'-hydroxyl groups

1987 • 11 citations

Oligoribonucleotide Synthesis By Use of the [[2-(Methylthio)phenyl]thio]methyl (MPTM) Group as the 2′-Hydroxyl Protecting Group

1991 • 11 citations

(2‐Cyano‐1,1‐dimethylethoxy)bis(diethylamino)phosphine: A convenient reagent for the synthesis of DNA fragments

1987 • 11 citations

Solid-phase ‘phosphite’ synthesis of oligonucleotides

1982 • 11 citations

Studies on the Formation of the Internucleotidic Bond in RNA Synthesis Using Dialkylamino Phosphoroamidites

1990 • 11 citations

Protection of the Lactam Function of 2′-Deoxyinosine with A 2-(4-Nitrophenyl)-Ethyl Moiety

1988 • 11 citations

The use of the p-nitrophenylethoxycarbonyl group for amino protection in cytidine and adenosine chemistry

1983 • 10 citations

DNA Synthesis on Solid Supports and Automation

1987 • 10 citations

Polymer support synthesis

1989 • 10 citations

Highly efficient synthesis of oligodeoxyribonucleotides using α-phenyl cinnamoyt group for selective amino protection

1989 • 10 citations

Die 2.2.2-Trichlor -tert-butyloxycarbonyl -Gruppe als N-Schutzgruppe bei Oligonukleotidsynthesen / The 2,2,2-Trichloro-tert-butoxycarbonyl Group, an N-Protecting Group in Oligonucleotide Synthesis

1981 • 10 citations

Synthese simplifiee de sondes mixtes avec des triazolo-nucleosides

1985 • 10 citations

Automated oligoribonucleotide synthesis on silica gel supports

1984 • 10 citations

Feature of Internucleotidic 2′,3′-Cyclicphosphate Intermediates During Liquid and Solid Phase Synthesis of RNA Fragments and Practical Synthesis of Octaadenylate in the Phosphoramidite Approach

1987 • 10 citations

Chemical Synthesis of RNA Fragments Related to the C4N Hypothesis

1986 • 10 citations

3,4-Dimethoxybenzyl group: A new protecting group for the guanosine residue during oligonucleotide synthesis.

1984 • 10 citations

New Results in Oligoribonucleotide Synthesis

1989 • 10 citations

Use of 2-Phenylsulfonylethyl as a Phosphate Protecting Group in DNA Synthesis Using the Phosphite-Triester Approach.

1985 • 10 citations

[18O] Chiral phosphate in d(CpA) and d(TpA): synthesis via phosphate triesters and assignment of configuration

1985 • 10 citations

A Simple, Preparative Procedure for<u>N</u>³-Anisoyluridine and<u>O</u>⁶-Diphenylcarbamoylguanosine 2′-O-(Tetrahydropyran-2-YL) Derivatives<u>via</u>The Corresponding 3′,5′-Dibenzoates

1988 • 10 citations

Synthesis of oligoribonucleotides by the phosphoramidite approach using 5′-levulinyl and 2′-tetrahydrofuranyl protection

1988 • 9 citations

(Butylthio)carbonyl Group: A New Protecting Group for the Guanine Residue in Oligoribonucleotide Synthesis

1987 • 9 citations

A new solid-phase synthesis of ribooligonucleotides using the 3'-phosphoro-p-anisidate protecting group for stepwise synthesis in the 3'-direction.

1985 • 9 citations

Use of the 2-(4-Pyridyl)Ethyl Protecting Group in the Synthesis of DNA Fragments Via Phosphoramidite Intermediates

1989 • 9 citations

Silica Gel Functionalised with Different Spacers as Solid Support for Oligonucleotide Synthesis

1988 • 9 citations

Uridine oligonucleotide synthesis by the reaction of uridine with tri-(imidazol-1-yl)phosphine

1981 • 9 citations

Phosphitylation of Guanine or Inosine Bases during the Preparation of Nucleoside Phosphoramidites. Isolation of Model Products as Thiophosphoric Amide Derivatives and Structure Elucidation by 15N NMR Spectroscopy.

1987 • 9 citations

Synthesis of an mRNA Fragment of Alanyl-tRNA Synthetase Gene in Escherichia coli Using the 6-Methyl-3-pyridyl Group for Protection of the Imide Functions of Uridine and Guanosine.

1986 • 9 citations

A New 5′-Protecting Group for Use in Solid-Phase Synthesis of Oligoribonucleotides

1987 • 9 citations

Practical Chemical Synthesis of RNA Fragments. Improvement in the Preparation of Ribonucleosidephosphoramidite Units

1990 • 9 citations

Oligonucleotide analogs with internucleoside phosphite links

1980 • 8 citations

Studies on transfer ribonucleic acids and related compounds. XXXIX. Chemical synthesis of heptadeca- and hexadecaribonucleotides corresponding to the 3'-terminus of the tRNAfMet of E. coli.

1981 • 8 citations

On the Phosphorylation of Deoxyribonucleosides and the Protection of Deoxyguanosine

1985 • 8 citations

Blockwise mechanical synthesis of oligonucleotides by the phosphoramidite method.

1987 • 8 citations

Arenesulfonylethoxycarbonyl- a Set of Amino Protecting Groups for DNA and RNA Synthesis

1988 • 8 citations

Chemical Synthesis of RNA

1987 • 8 citations

Evaluation of the Use of the t-Butyldimethylsilyl Group for 2′-Protection in RNA-Synthesis Via the H-Phosphonate Approach

1988 • 8 citations

The automated synthesis of oligodeoxyribonucleotides

1985 • 8 citations

Methylation of Pyrimidine 2′-Deoxynucleosides with Trimethyl Phosphate

1979 • 8 citations

Oligonucleotidic compounds. XVIII. Synthesis of guanylyl-(3'→5')-uridylyl-(3'→5')-arabinofuranosyluracil and guanylyl-(3'→5')-uridylyl-(3'→5')-arabinofuranosylcytosine

1967 • 8 citations

Substituent Influence on the Reaction Rate of Deoxyribonucleoside Phosphoramidites with Deoxyribonucleosides Catalysed by Tetrazole

1987 • 7 citations

Synthesis of oligoribonucleotides via the phosphite-triester approach on a polymer support.

1986 • 7 citations

The Utility of 2′-Thp Group in the Synthesis of the Relatively Long RNA Fragments on the Solid Phase

1990 • 7 citations

Protection de la liaison glycosidique en serie desoxy-2′ adenosine

1983 • 7 citations

Synthesis of Oligodeoxyribonucleotides Involving a Rapid Procedure for Removal of Base-Protecting Groups by Use of the 4,4′,4″-Tris(benzoyloxy)trityl (TBTr) Group

1986 • 7 citations

2'(3')-O-Glycyl oligoribonucleotides with sequences of the 3'-terminus of glycyl-tRNA: chemical synthesis and properties in partial reactions of protein biosynthesis

1987 • 7 citations

The Protection of The 2′-Hydroxyl Function in Oligoribonucleotide Synthesis

1985 • 7 citations

Recent Progress in Oligoribonucleotide Synthesis

1988 • 7 citations

Synthesis of Oligoribonucleotides by Using 2′-O-(1-Methyl-1-methoxy)ethyl Nucleosides

1987 • 7 citations

The Chemical Syntheses of (2′-5′)-P-Thioadenylate Dimers, Trimers and Tetramers

1988 • 7 citations

p-Nitrophenylethyl-Phosphoramidites

1985 • 6 citations

USE OF 2-(2-PYRIDYL)ETHYL GROUP AS A NEW PROTECTING GROUP OF INTERNUCLEOTIDIC PHOSPHATES IN OLIGONUCLEOTIDE SYNTHESIS

1986 • 6 citations

Amide Protection in Oligodeoxynucleotide Synthesis

1987 • 6 citations

Interaction of AD2+D2 protein and simian virus 40 large T antigen with the large tumor antigen binding site I

1984 • 6 citations

The p-Phenylazophenyloxycarbonyl Protecting Group: Selective Deblocking and Oligonucleotide Synthesis Avoiding Acid Steps

1985 • 6 citations

Phosphoramidites of Chiral (R_p)‐and (S_p)‐Configurated d(T[P‐¹⁸O]‐A): Synthesis, Configurational Assignment, and Use as Dimer Blocks in Oligonucleotide Synthesis

1985 • 6 citations

Automated Solid Phase Synthesis of Oligoribonucleotides. The Synthesis of a tRNA Anticodon Loop from Nucleoside-3'-chlorophosphite Derivatives.

1984 • 6 citations

Use of the (butylthio)carbonyl group to protect uracil and guanine residues in oligoribonucleotide synthesis.

1987 • 6 citations

New Approach to the Synthesis of 2′(3′)-O-Aminoacyloligoribonucleotides Related to the 3′-Terminus of Aminoacyl Transfer Ribonucleic Acid

1987 • 6 citations

Synthesis of Oligoribonucleotides by Use of 4,4′,4″-Tris(acyloxy)trityl Groups for Protection of the 6-Amino Group of Adenosine

1988 • 6 citations

Polymer Support Oligonucleotide Synthesis XVI: Synthesis of Oligonucleotides Using Suitably Protected Deoxynucleoside-N-morpholinophosphoramidites on Porous Glass Beads

1984 • 5 citations

O⁶-Protection and Other Transformations at Guanosine and Inosine Lactam Sites with Application of Related Pyridinium Salts

1987 • 5 citations

Solid Phase Synthesis of Oligodeoxyribonucleotides Utilizing the Phenylthio Group as a Phosphate Protecting Group

1987 • 5 citations

Bausteine für Oligonucleotid-Synthesen mit einheitlich fragmentierbaren β-halogenierten Schutzgruppen /Building Blocks for Oligonucleotide Syntheses with Uniformly Fragmentable β-Halogenated Protecting Groups

1987 • 5 citations

Synthesis of the oligodeoxyribonucleotide, d(CpTpGpGpApTpCpCpApG), and its substrate activity with the restriction endonuclease, BamHI

1985 • 5 citations

2′-OH Protection by the p-Nitrophenylethylsulfonyl (NPES) Group in Oligoribonucleotide Synthesis

1987 • 5 citations

Chemical Synthesis of Oligodeoxyribonucleotides: A Simplified Procedure

1983 • 5 citations

Use of the 2-(2-Pyridyl)Ethyl Protecting Group in the Synthesis of DNA Fragments via Phosphoramidite Intermediates

1987 • 5 citations

Three-phase - Synthesis of Oligonucleotides

1985 • 4 citations

THE TERT-BUTYLDIMETHYLSILYL GROUP AS A PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS

1978 • 4 citations

Regiospecific cleavage of RNA by RNase H from E. coli in the presence of a complementary oligonucleotide with inserted alternating 2'-O-methylcytidine residues

1990 • 4 citations

An improved iodine/water oxidation reagent for automated oligonucleotide synthesis

1987 • 4 citations

Synthesis of functionalized dna fragments suitable for reversible attachment to activated cellulose

1979 • 4 citations

Synthesis and characterization of a ribavirin-3′, 5′-phosphate pentadecamer homoribopolymer bearing a 5′-amino tether group and a 3′-thymidine

1990 • 4 citations

A Solid-Phase Synthesis of 2',5'-Linked Oligoadenylates (2-5A)

1989 • 3 citations

One-Step Protection of the Guanine Moiety in 2′-Deoxyguanosine and Guanosine

1987 • 3 citations

New Trityl-Based Protecting Groups with a Mild Two-Step Removal

1988 • 3 citations

Studies on transfer ribonucleic acids (tRNA) and related compounds. XLIX. Solid-phase synthesis of nonadecaribonucleotide corresponding to the 5'-half of the formylmethionine tRNA deficient in D-loop and stem region.

1985 • 3 citations

THE ALKYLSILYL PROTECTING GROUPS:IN PARTICULAR, THE T-BUTYLDIMETHYLSILYL GROUP IN NUCLEOSIDE AND NUCLEOTIDE CHEMISTRY

1983 • 3 citations

Phosphoramidites of [180] Chiral (Rp)- and (Sp)-Configurated Dimer-Blocks and their Use in Automated Oligonucleotide Synthesis

1987 • 3 citations

Partial Protection of Carbohydrate Derivatives. Part 24.¹Synthesis of Adenylyl-(2′–5′)-Adenylyl-(2′–5′)-Adenosine Using a 3′-<u>O</u>-(Tetrahydropyran-2-YL) Adenosine Derivative

1987 • 2 citations

TOTAL SYNTHESIS OF A BACTERIAL GENE II: THE TOTAL DNA INCLUDING THE PROMOTER AND ITS TRANSCRIPTION

1978 • 2 citations

Phosphoramidites as Synthons for Polynucleotide Synthesis

1987 • 2 citations

Nucleophilic catalysis in the oligonucleotide synthesis.

1987 • 2 citations

Oxygen Chiral Phosphate in Ribo- and 2′-Deoxyribodinucleoside Monophosphates by Oxidation of Phosphite Intermediates

1985 • 2 citations

ChemInform Abstract: Some Aspects of Oligoribonucleotide Chemistry

1986 • 1 citations

A New Method for Synthesizing RNA on Silica Supports

1987 • 1 citations

ChemInform Abstract: Tetraisopropyldisiloxane‐1,3‐diyl Group, its Mode of Action and Usefulness in the Chemical Synthesis of Oligonucleotides and Modification of Nucleosides and Carbohydrates

1986 • 1 citations

Oligoribonucleotide Synthesis by the Phosphite Procedure from 2′-Dimethoxytritylated Nucleosides

1985 • 1 citations

ChemInform Abstract: Rapid Solid‐Phase Phosphotriester Synthesis of DNA Fragments on Controlled Pore Glass and Application to the Preparation of a Gene for Somatomedin C

1988 • 1 citations

Deleted Work

1955 • 0 citations