Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells

Nile red: a selective fluorescent stain for intracellular lipid droplets.

1985 • 2,346 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1989 • 533 citations

Golgi-disturbing agents

1998 • 375 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

1993 • 363 citations

Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

1997 • 306 citations

Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

1997 • 290 citations

Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis

2000 • 283 citations

Improved Inhibitors of Glucosylceramide Synthase

1999 • 243 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Involvement of de NovoCeramide Biosynthesis in Tumor Necrosis Factor-α/Cycloheximide-induced Cerebral Endothelial Cell Death

1998 • 182 citations

Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell Death

2000 • 174 citations

Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells

2000 • 156 citations

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

2001 • 136 citations

Differential Roles of de Novo Sphingolipid Biosynthesis and Turnover in the “Burst” of Free Sphingosine and Sphinganine, and Their 1-Phosphates and N-Acyl-Derivatives, That Occurs upon Changing the Medium of Cells in Culture

1995 • 135 citations

Brefeldin A Is a Potent Inducer of Apoptosis in Human Cancer Cells Independently of p53

1996 • 115 citations

Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets

2001 • 113 citations

Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

1999 • 106 citations

CPT-11 (Irinotecan) in the treatment of colorectal cancer

1995 • 104 citations

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.

1996 • 83 citations

Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy.

1999 • 81 citations

Sequential Operation of Ceramide Synthesis and ICE Cascade in CPT-11-Initiated Apoptotic Death Signaling

1997 • 74 citations

1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine.

2000 • 69 citations

Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway

1998 • 55 citations

Metabolism and apoptotic properties of elevated ceramide in HT29rev cells

1998 • 52 citations

Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells.

1999 • 47 citations

PDMP Blocks Brefeldin A–induced Retrograde Membrane Transport from Golgi to ER: Evidence for Involvement of Calcium Homeostasis and Dissociation from Sphingolipid Metabolism

1998 • 47 citations

Schedule-dependent cytotoxicity of SN-38 in p53 wild-type and mutant colon adenocarcinoma cell lines

1999 • 40 citations

Sphingomyelin-degrading pathways in human cells

1999 • 37 citations

SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein

2000 • 30 citations

New syntheses of 1d- and 1l-1,2-anhydro-myo-inositol and assessment of their glycosidase inhibitory activities

2000 • 28 citations

Glutathione modulates lipid composition of human colon derived HT-29 cells

1998 • 22 citations

Characterization and localization of neutral sphingomyelinase in bovine adrenal medulla.

1986 • 20 citations

De Novo Synthesis and Recycling Pathways of Sphingomyelin in Rat Sertoli Cells

2001 • 15 citations

[Second-line irinotecan chemotherapy in the treatment of metastatic colorectal cancers: phase III trials].

1998 • 9 citations

Niemann-Pick disease: Coupling and uncoupling of inhibited sphingomyelinase activity and exogenous cholesterol esterification in fibroblasts by ionophore treatment

1994 • 8 citations