Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Tumor suppressor genes

1991 • 775 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

p53 mutation in hepatocellular carcinoma after aflatoxin exposure

1991 • 448 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

1991 • 385 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

Base substitution mutations induced by metabolically activated aflatoxin B1.

1983 • 278 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

1990 • 236 citations

[Tumors of the liver].

1955 • 223 citations

Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization.

1992 • 204 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

Hepatocellular carcinoma

1992 • 180 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas.

1991 • 128 citations

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest.

1992 • 123 citations

Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from britain

1992 • 105 citations

p53 Mutations in human hepatocellular carcinomas from Germany.

1992 • 90 citations

Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas.

1992 • 83 citations

Overexpression of p53: A rare event in a large series of white patients with hepatocellular carcinoma

1992 • 53 citations

Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination.

1992 • 45 citations

A chromosome 17:7 translocation is associated with a hepatitis B virus DNA integration in human hepatocellular carcinoma DNA

1992 • 38 citations

Alterations in the structural gene and the expression of p53 in rat liver tumors induced by aflatoxin B₁

1992 • 32 citations

Alterations in the p53 tumor suppressor gene in rat liver tumors induced by aflatoxin B1.

1992 • 14 citations