Mismatch repair: mechanisms and relationship to cancer susceptibility

DNA Repair and Mutagenesis

2006 • 4,725 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

DNA Mismatch Correction in a Defined System

1989 • 551 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli

1984 • 468 citations

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

1993 • 437 citations

Mismatch Repair, Genetic Stability, and Cancer

1994 • 429 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

1994 • 329 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

A repair system for 8-Oxo-7,8-dihydrodeoxyguanine

1992 • 311 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

1994 • 287 citations

Microsatellite instability in inherited and sporadic neoplasms

1995 • 257 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

1995 • 219 citations

The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.

1993 • 216 citations

Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae.

1995 • 201 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

1994 • 166 citations

Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.

1994 • 146 citations

The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease

1991 • 135 citations

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

1995 • 106 citations

Mismatch repair of deaminated 5-methyl-cytosine

1987 • 88 citations

The role of heteroduplex correction in gene conversion in Saccharomyces cerevisiae

1987 • 86 citations

Mismatch repair and cancer susceptibility

1994 • 64 citations