Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis

Genomic sequencing.

1984 • 8,343 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

Requirement of c-kit for development of intestinal pacemaker system

1992 • 700 citations

Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1988 • 663 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

A monoclonal antibody discriminating between subsets of T and B cells.

1981 • 565 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

Control points in early T-cell development

1993 • 429 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.

1990 • 349 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

Subsets of CD3⁺ (T cell receptor α/β or γ/δ) and CD3⁻ lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1990 • 269 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

1991 • 262 citations

Phenotypic complexity of intraepithelial lymphocytes of the small intestine.

1991 • 252 citations

The Steel factor

1992 • 201 citations

Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.

1992 • 194 citations

Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody.

1989 • 151 citations

Extrathymic selection of TCR γδ+ T cells by class II major histocompatibility complex molecules

1990 • 145 citations

Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras.

1990 • 144 citations

Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: Implications for differentiation of cells bearing a CD3‐associated γδ T cell receptor

1990 • 116 citations

Different expression of the recombination activity gene RAG‐1 in various populations of thymocytes, peripheral T cells and gut thymus‐independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement

1992 • 107 citations

A low-temperature method for the isolation of small-intestinal epithelium along the crypt-villus axis

1991 • 103 citations

CD4⁺ CD8⁺ murine intestinal intraepithelial Iymphocytes

1990 • 90 citations

Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes

1993 • 86 citations

Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.

1992 • 72 citations

FACS Purification of Bone Marrow-Derived Epidermal Populations in Mice: Langerhans Cells and Thy-1+ Dendritic Cells

1985 • 72 citations

A novel pathway of thymus-directed T lymphocyte maturation.

1994 • 69 citations

Mucosal immunology : intraepithelial lymphocytes

1994 • 45 citations

Lymphoid and erythroid repopulation in B6 W-anemic mice: a new unirradiated recipient.

1991 • 37 citations

Untransfected and SV40-transfected fetal and postnatal human thymic stromal cells. Analysis of phenotype, cytokine gene expression and cytokine production.

1993 • 24 citations

[60] Detection by immunochemical techniques of cell surface markers on epidermal Langerhans cells

1984 • 23 citations