Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease.

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

1996 • 937 citations

Total Body Irradiation and Acute Graft-Versus-Host Disease: The Role of Gastrointestinal Damage and Inflammatory Cytokines

1997 • 838 citations

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

1990 • 643 citations

Bacterial Endotoxins and Host Immune Responses

1980 • 629 citations

The biology of graft-versus-host reactions.

1966 • 627 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments]

1990 • 591 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 565 citations

Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses.

1988 • 441 citations

Graft-versus-Host Disease and Survival in Patients with Aplastic Anemia Treated by Marrow Grafts from HLA-Identical Siblings

1983 • 433 citations

Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease.

1992 • 385 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2- incompatible transplanted SCID mice

1994 • 348 citations

LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.

1998 • 346 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

E5531, a Pure Endotoxin Antagonist of High Potency

1995 • 322 citations

Mitigation of Secondary Disease of Allogeneic Mouse Radiation Chimeras by Modification of the Intestinal Microflora

1974 • 321 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice

1978 • 284 citations

Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.

1998 • 276 citations

RISK FACTORS FOR ACUTE GRAFT-VERSUS-HOST DISEASE IN HISTOCOMPATIBLE DONOR BONE MARROW TRANSPLANTATION

1991 • 271 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

Critical involvement of transmembrane tumor necrosis factor-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin

1995 • 207 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

Endotoxin protein: a B-cell mitogen and polyclonal activator of C3H/HeJ lymphocytes.

1976 • 198 citations

IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kappaB.

1997 • 198 citations

Modulation of acute graft-versus-host-disease after allogeneic bone marrow transplantation by tumor necrosis factor alpha (TNF alpha) release in the course of pretransplant conditioning: role of conditioning regimens and prophylactic application of a monoclonal antibody neutralizing human TNF alpha (MAK 195F)

1995 • 198 citations

Mechanisms of endotoxin shock and endotoxin hypersensitivity

1993 • 197 citations

A histopathologic study of gastric and small intestinal graft-versus-host disease following allogeneic bone marrow transplantation

1985 • 173 citations

Hepatic Graft Versus Host Disease: A Study of the Predictive Value of Liver Biopsy in Diagnosis

1984 • 169 citations

Host-Specific Interleukin-2–Secreting Donor T-Cell Precursors as Predictors of Acute Graft-versus-Host Disease in Bone Marrow Transplantation between HLA-Identical Siblings

1992 • 167 citations

Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation.

1989 • 165 citations

Antibodies against CD14 protect primates from endotoxin-induced shock.

1996 • 152 citations

Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha

1993 • 151 citations

Bone marrow transplantation in patients aged 45 years and older

1986 • 150 citations

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.

1997 • 148 citations

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment.

1994 • 147 citations

Recombinant soluble CD14 prevents mortality in mice treated with endotoxin (lipopolysaccharide).

1995 • 134 citations

Role of Bacterial Microflora in Development of Intestinal Lesions From Graft-Versus-Host Reaction

1977 • 132 citations

TNF alpha levels are increased during bone marrow transplantation conditioning in patients who develop acute GVHD.

1995 • 126 citations

Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease.

1998 • 125 citations

Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles.

1976 • 89 citations

The role of cytokines in acute graft-versus-host disease.

1997 • 70 citations

Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome.

1993 • 68 citations

Genetic Control of B Cell Activation by Bacterial Lipopolysaccharide Is Mediated by Multiple Distinct Genes or Alleles

1976 • 65 citations

TRANSPLANTATION OF POLARIZED TYPE 2 DONOR T CELLS REDUCES MORTALITY CAUSED BY EXPERIMENTAL GRAFT-VERSUS-HOST DISEASE1

1996 • 65 citations

Mice Genetically Hyporesponsive to Lipopolysaccharide (LPS) Exhibit a Defect in Endocytic Uptake of LPS and Ceramide

1997 • 64 citations

Inflammatory reactions induced by pretransplant conditioning—An alternative target for modulation of acute GvHD and Complications following allogeneic bone marrow transplantation?

1997 • 63 citations

Lipopolysaccharide nonresponder cells: The C3H/HeJ defect

1993 • 61 citations

Correlation of minor histocompatibility antigen-specific cytotoxic T lymphocytes with graft-versus-host disease status and analyses of tissue distribution of their target antigens

1993 • 61 citations

Effect of IgM‐enriched intravenous immunoglobulin (Pentaglobin) on endotoxaemia and anti‐endotoxin antibodies in bone marrow transplantation

1993 • 60 citations

EFFECTOR MECHANISMS IN GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1990 • 59 citations

EFFECTOR MECHANISMS IN GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1990 • 56 citations

THE EFFECT OF DONOR T LYMPHOCYTES AND TOTAL-BODY IRRADIATION ON HEMOPOIETIC ENGRAFTMENT AND PULMONARY TOXICITY FOLLOWING EXPERIMENTAL ALLOGENEIC BONE MARROW TRANSPLANTATION

1992 • 53 citations

Pharmacokinetic Parameters and Biodistribution of Soluble Cytokine Receptors

1993 • 35 citations

An in vitro predictive test for clinical graft-versus-host disease in allogeneic bone marrow transplant recipients.

1990 • 31 citations

DIAGNOSIS OF GRAFT-VERSUS-HOST DISEASE IN MICE TRANSPLANTED ACROSS MINOR HISTOCOMPATIBILITY BARRIERS

1990 • 31 citations

Progressive Accumulation of Bacterial Lipopolysaccharide In Vivo During Murine Acute Graft‐Versus‐Host Disease

1997 • 31 citations

Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2- incompatible transplanted SCID mice

1994 • 28 citations

Intestinal graft-versus-host disease

1992 • 25 citations

AN ANALYSIS OF PULMONARY NATURAL KILLER CELL ACTIVITY IN F1-HYBRID MICE WITH ACUTE GRAFT-TERSUS-HOST REACTIONS

1988 • 24 citations

SERUM LEVELS OF CYTOKINES AND SECONDARY MESSAGES AFTER T-CELL-DEPLETED AND NON-T-CELL-DEPLETED BONE MARROW TRANSPLANTATION

1996 • 21 citations

PREVENTION OF ACUTE LETHAL GRAFT-VERSUS-HOST DISEASE IN F1 HYBRID MICE BY PRETREATMENT OF THE GRAFT WITH ANTI-NK-1.1 AND COMPLEMENT

1992 • 19 citations

Lymphocyte Activation by Endotoxin and Endotoxin Protein The Role of the C3H/HeJ Mouse

1983 • 13 citations

Lung and gut injury induced by tumour necrosis factor

1993 • 8 citations

Bone marrow transplantation in patients aged 45 years and older

1986 • 6 citations

A Study of Donor Alloreactivity, which may predict Acute Graft‐Versus‐Host Disease in HLA Identical Bone Marrow Transplantations for Early Leukaemia

1992 • 6 citations

Measurement of recipient-specific alloreactivity: is GVHD predictable?

1993 • 4 citations