Intestinal graft-versus-host disease

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

The biology of graft-versus-host reactions.

1966 • 627 citations

Allogeneic Bone‐Marrow Transplantation

1983 • 614 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Graft Versus Host Reactions. Their Natural History, and Applicability as Tools of Research

2015 • 550 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

1978 • 422 citations

Studies of endotoxin-induced decrease in lipoprotein lipase activity.

1981 • 333 citations

Mitigation of Secondary Disease of Allogeneic Mouse Radiation Chimeras by Modification of the Intestinal Microflora

1974 • 321 citations

Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor.

1983 • 294 citations

The mosaic of autoimmunity

1989 • 292 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

Intestinal and Hepatic Complications of Human Bone Marrow Transplantation. Part II

1986 • 270 citations

Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli.

1982 • 239 citations

Intestinal and hepatic complications of human bone marrow transplantation. Part I

1986 • 232 citations

T CELL SUBSETS AND GRAFT-VERSUS-HOST DISEASE

1987 • 223 citations

Protective Environment for Marrow Transplant Recipients

1978 • 216 citations

The graft versus host reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implication

1973 • 212 citations

Mortality and Gross Pathology of Secondary Disease in Germfree Mouse Radiation Chimeras

1971 • 205 citations

Lymphocytic Bronchitis Associated with Graft-versus-Host Disease in Recipients of Bone-Marrow Transplants

1978 • 179 citations

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.

1989 • 178 citations

A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation

1988 • 177 citations

Hepatic Graft Versus Host Disease: A Study of the Predictive Value of Liver Biopsy in Diagnosis

1984 • 169 citations

Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease.

1987 • 169 citations

Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig.

1988 • 159 citations

Fate of H2-activated T lymphocytes in syngeneic hosts

1976 • 147 citations

Intraepithelial Lymphocyte Count and Crypt Hyperplasia Measure the Mucosal Component of the Graft-versus-Host Reaction in Mouse Small Intestine

1982 • 142 citations

Gut injury in mouse graft-versus-host reaction. Study of its occurrence and mechanisms.

1986 • 135 citations

Role of Bacterial Microflora in Development of Intestinal Lesions From Graft-Versus-Host Reaction

1977 • 132 citations

AUGMENTATION OF GRAFT-VERSUS-HOST REACTION BY CYTOMEGALOVIRUS INFECTION RESULTING IN INTERSTITIAL PNEUMONITIS

1985 • 107 citations

ACQUIRED TOLERANCE OF SKIN HOMOGRAFTS

1955 • 106 citations

The Pathology of Bone Marrow Transplantation

1985 • 101 citations

Diffuse intestinal ulceration after marrow transplantation: A clinicopathologic study of 13 patients

1986 • 101 citations

The Functional and Histological Basis for Graft‐versus‐Host‐Induced Immunosuppression

1985 • 100 citations

Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non-H-2 histocompatibility barriers.

1979 • 89 citations

The pathology of bone marrow transplantation.

1974 • 89 citations

Pneumopathies of the graft-versus-host reaction. Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis.

1989 • 89 citations

Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines.

1989 • 78 citations

Pathological changes in F1 hybrid mice following transplantation of spleen cells from donors of the parental strains.

1959 • 77 citations

HYPERSENSITIVITY REACTIONS IN THE SMALL INTESTINE

1981 • 71 citations

Graft-Versus-Host Disease of the Intestine: A Protein Losing Enteropathy Characterized by Fecal α1-Antitrypsin

1983 • 71 citations

Local immune responses of the gut

1986 • 70 citations

Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells.

1978 • 67 citations

Small intestinal injury in the graft versus host reaction: an innocent bystander phenomenon.

1977 • 66 citations

B CELL, HELPER T CELL, AND SUPPRESSOR T CELL ABNORMALITIES CONTRIBUTE TO DISORDERED IMMUNOGLOBULIN SYNTHESIS IN PATIENTS FOLLOWING BONE MARROW TRANSPLANTATION

1982 • 64 citations

SERUM TUMOR NECROSIS FACTOR ALPHA ASSOCIATED WITH ACUTE GRAFT-VERSUS-HOST DISEASE IN HUMANS

1990 • 64 citations

Graft-vs.-Host Disease: Immunology, Pathophysiology, and Treatment

1991 • 62 citations

BLOOD CYCLOSPORINE PHARMACOKINETICS IN PATIENTS UNDERGOING MARROW TRANSPLANTATION INFLUENCE OF AGE, OBESITY, AND HEMATOCRIT

1988 • 62 citations

RUNT INTESTINAL DISEASE.

1965 • 61 citations

Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes.

1981 • 60 citations

Small Intestinal Injury in the Graft Versus Host Reaction: An Innocent Bystander Phenomenon

1977 • 56 citations

AUGMENTATION OF INTESTINAL AND PERIPHERAL NATURAL KILLER CELL ACTIVITY DURING THE GRAFT-VERSUS-HOST REACTION IN MICE

1983 • 53 citations

Human Gastrointestinal Development

1990 • 52 citations

CLASS II ANTIGEN EXPRESSION BY KERATINOCYTES AND ENTEROCYTES—AN EARLY FEATURE OF GRAFT-VERSUS-HOST-DISEASE

1988 • 45 citations

NATURAL KILLER ACTIVITY BY SPLEEN, LYMPH NODE, AND THYMUS CELLS DURING THE GRAFT-VERSUS-HOST REACTION1

1982 • 44 citations

Histological features of skin and rectal biopsy specimens after autologous and allogeneic bone marrow transplantation.

1988 • 43 citations

An immunohistological study of human hepatic graft-versus-host disease.

1985 • 42 citations

Intestinal hypersensitivity reactions in the rat. I. Uptake of intact protein, permeability to sugars and their correlation with mucosal mast-cell activation.

1988 • 42 citations

GRAFT-VERSUS-HOST DISEASE INDUCED BY SMALL BOWEL ALLOGRAFTS

1986 • 42 citations

Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli.

1986 • 39 citations

The contribution of intestinal endotoxin to mortality in hosts with compromised resistance: a review.

1978 • 38 citations

Hypersensitivity reactions in the small intestine. VII. Induction of the intestinal phase of murine graft-versus-host-reaction by Lyt 2- T cells activated by I-A alloantigens.

1986 • 34 citations

GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.

1985 • 34 citations

Histologic similarity of murine colonic graft-versus-host disease (GVHD) to human colonic GVHD and inflammatory bowel disease.

1990 • 33 citations

Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.

1983 • 32 citations

Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes.

1989 • 32 citations

Prevention of oral tolerance induction to ovalbumin and enhanced antigen presentation during a graft-versus-host reaction in mice.

1985 • 31 citations

PROTEIN-LOSING ENTEROPATHY IN THE GRAFT-VERSUS-HOST REACTION

1970 • 30 citations

Selective IgA deficiency and circulating immune complexes containing bovine proteins in a child with chronic graft versus host disease

1979 • 27 citations

HYPERSENSITIVITY REACTIONS IN THE SMALL INTESTINE

1986 • 26 citations

Role of L3T4+ and Lyt-2+ donor cells in graft-versus-host immune deficiency induced across a class I, class II, or whole H-2 difference.

1988 • 26 citations

INTESTINAL PHASE OF THE RUNTING SYNDROME IN MICE

1968 • 25 citations

Experimental studies of immunologically mediated enteropathy. V. Destructive enteropathy during an acute graft-versus-host reaction in adult BDF1 mice

1990 • 25 citations

Experimental studies of immunologically mediated enteropathy. Development of cell mediated immunity and intestinal pathology during a graft-versus-host reaction in irradiated mice.

1988 • 24 citations

INDUCTION OF GRAFT-VERSUS-HOST DISEASE BY SMALL INTESTINAL ALLOTRANSPLANTATION IN RATS

1985 • 23 citations

Hypersensitivity Reactions in the Small Intestine

1978 • 21 citations

Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.

1987 • 20 citations

Selective effects of graft-versus-host reaction on disaccharidase expression by mouse jejunal enterocytes

1986 • 19 citations

INDUCTION OF INTESTINAL GRAFT-VERSUS-HOST REACTIONS ACROSS MUTANT MAJOR HISTOCOMPATIBILITY ANTIGENS BY T LYMPHOCYTE SUBSETS IN MICE

1989 • 19 citations

Evidence for the in vivo production and release into the serum of a T-cell lymphokine, persisting-cell stimulating factor (PSF), during graft-versus-host reactions.

1986 • 18 citations

IMMUNOPATHOLOGY OF GRAFT-VERSUS-HOST DISEASE IN THE UPPER GASTROINTESTINAL TRACT

1989 • 15 citations

DEVELOPMENT OF IgA DEFICIENCY AFTER BONE MARROW TRANSPLANTATION

1990 • 14 citations

PATHOLOGIC CHANGES IN OLD NONIRRADIATED F1 HYBRID MICE INJECTED WITH PARENTAL-STRAIN SPLEEN CELLS

1959 • 14 citations

Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice.

1987 • 14 citations

Augmentation of Natural Killer Cell Activity by Anti‐Host Delayed‐Type Hypersensitivity during the Graft‐versus‐Host Reaction in Mice

1985 • 14 citations

Epidermal lesions of the GVHR: evaluation of the role of different MHC and non MHC loci and of the Ly-2+ and L3T4+ T lymphocytes.

1987 • 13 citations

Small intestinal injury in the immunologically runted mouse. Morphologic and autoradiographic studies.

1971 • 13 citations

Experimental Studies of Immunologically Mediated Enteropathy.

1990 • 13 citations

EVIDENCE THAT Ia+ BONE-MARROW-DERIVED CELLS ARE THE STIMULUS FOR THE INTESTINAL PHASE OF THE MURINE GRAFT-VERSUS-HOST REACTION

1986 • 13 citations

Functional T cell deficits after bone marrow transplantation across minor histocompatibility barriers: effects of graft-vs-host disease on precursor frequency of reactive cells.

1987 • 12 citations

FAILURE OF T AND B CELL COOPERATION DURING GRAFT-VERSUS-HOST DISEASE

1981 • 12 citations

Evidence that nonlymphoid tissue injury in acute graft-versus-host disease is limited to epithelial cells aberrantly expressing MHC antigens.

1989 • 12 citations

Experimental studies of immunologically mediated enteropathy: IV. Correlation between immune effector mechanisms and type of enteropathy during a GvHR in neonatal mice of different ages.

1988 • 11 citations

Graft-versus-host disease of the intestine

1990 • 11 citations

HEMATOLOGICAL AND PATHOLOGICAL CHANGES INDUCED IN TOLERANT MICE BY THE INJECTION OF SYNGENEIC LYMPHOID CELLS

1968 • 10 citations

INFLUENCE OF ENDOTOXIN ON GRAFT-VERSUS-HOST DISEASE AFTER BONE MARROW TRANSPLANTATION ACROSS MAJOR HISTOCOMPATIBILITY BARRIERS IN MICE

1987 • 8 citations

EFFECT OF IMMUNIZATION WITH ESCHERICHIA COLI J5 ON GRAFT-VERSUS-HOST DISEASE INDUCED BY MINOR HISTOCOMPATIBILITY ANTIGENS IN MICE

1987 • 7 citations

Isolated peripheral T cells from GvHR recipients exhibit defective IL-2R expression, IL-2 production, and proliferation in response to activation stimuli.

1990 • 7 citations

Acute lethal graft-versus-host disease stimulates cellular proliferation in Peyer’s Patches and follicle associated ileal epithelium of adult rats

1984 • 6 citations

Role of Mucosal Mast Cells in Intestinal Graft-versus-Host Reaction in the Mouse

1990 • 5 citations

Duodenal Immunoglobulin Deficiency in Graft Versus Host Disease (GVHD) Mice

1976 • 5 citations

Effects of Anti-CD11a, Anti-CD11b and Anti-CD 18 on Histamine Release from Human Basophils Primed with IL-3

1992 • 5 citations

Effect of cyclosporin A treatment on the enteropathy of graft‐versus‐host reaction in the rat: A quantitative study of intestinal morphology, epithelial cell kinetics and mucosal immune activity

1989 • 4 citations

Intestinal Mucosal Mast Cells in Rats With Graft-Versus-Host Reaction

1987 • 2 citations