A transgenic mouse model of the ubiquitin/proteasome system

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

‘Green mice’ as a source of ubiquitous green cells

1997 • 2,586 citations

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2001 • 2,167 citations

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

1998 • 1,592 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity

1999 • 914 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

Conformational disease

1997 • 794 citations

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

1998 • 730 citations

Regulation and function of the p53 tumor suppressor protein

2001 • 716 citations

Regulation of the Cdk inhibitor p27 and its deregulation in cancer

2000 • 680 citations

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

2000 • 574 citations

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients

1998 • 558 citations

A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies.

2002 • 446 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

A Long CAG Repeat in the Mouse Sca1 Locus Replicates SCA1 Features and Reveals the Impact of Protein Solubility on Selective Neurodegeneration

2002 • 343 citations

Protein misfolding and disease; protein refolding and therapy

2001 • 335 citations

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease

2000 • 330 citations

HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

2002 • 310 citations

Protein Misfolding, Amyloid Formation, and Neurodegeneration

2002 • 306 citations

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins

2002 • 292 citations

Lessons from animal models of Huntington's disease

2002 • 288 citations

Genetically engineered mouse models of neurodegenerative diseases

2002 • 232 citations

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

2002 • 220 citations

Mallory bodies revisited

2000 • 205 citations

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

2001 • 199 citations

Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

1999 • 158 citations

Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma

2002 • 146 citations

Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors

2001 • 121 citations

Regulation of the G1 to S transition by the ubiquitin pathway

2001 • 120 citations

Parkin and Parkinsonʼs disease

2001 • 117 citations

Protein Misfolding and Disease

2003 • 113 citations

Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model

2002 • 104 citations

Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model

2002 • 94 citations

Aggresome Formation in Liver Cells in Response to Different Toxic Mechanisms: Role of the Ubiquitin-Proteasome Pathway and the Frameshift Mutant of Ubiquitin

2001 • 78 citations

Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome

1997 • 61 citations

A PROTEASOME INHIBITOR EFFECTIVELY PREVENTS MOUSE HEART ALLOGRAFT REJECTION1

2001 • 58 citations

Proteasome activation as a critical event of thymocyte apoptosis

2000 • 47 citations

Monitoring the ubiquitin/proteasome system in conformational diseases

2003 • 41 citations

Protection against experimental autoimmune encephalomyelitis by a proteasome modulator

2001 • 28 citations

Intranuclear Inclusions and the Ubiquitin–Proteasome Pathway

1999 • 15 citations