Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Report of the Ad Hoc Committee on Reconciliation of Approaches to Bacterial Systematics

1987 • 7,186 citations

Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations

1990 • 3,992 citations

The characterization of enzymatically amplified eukaryotic 16S-like rRNA-coding regions

1988 • 2,828 citations

‘Touchdown’ PCR to circumvent spurious priming during gene amplification

1991 • 2,630 citations

Genetic diversity in Sargasso Sea bacterioplankton

1990 • 1,666 citations

16S rRNA sequences reveal numerous uncultured microorganisms in a natural community

1990 • 1,401 citations

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 • 1,295 citations

The Polymerase Chain Reaction

1990 • 1,198 citations

Compilation of small ribosomal subunit RNA sequences

1992 • 985 citations

[31] Detection and localization of single base changes by denaturing gradient gel electrophoresis

1987 • 944 citations

DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory.

1983 • 895 citations

Phylogenetic group-specific oligodeoxynucleotide probes for identification of single microbial cells

1988 • 704 citations

Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis

1985 • 606 citations

Evolutionary relationships among cyanobacteria and green chloroplasts

1988 • 509 citations

Molecular and microscopic identification of sulfate-reducing bacteria in multispecies biofilms

1992 • 453 citations

Length-independent separation of DNA restriction fragments in two-dimensional gel electrophoresis

1979 • 341 citations

Sequence-Determined DNA Separations

1984 • 210 citations

Two-dimensional DNA fingerprinting of human individuals.

1989 • 80 citations

Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich.

1988 • 69 citations

Mapping point mutations in the Drosophila rosy locus using denaturing gradient gel blots.

1991 • 57 citations

Detection of base mutations in genomic DNA using denaturing gradient gel electrophoresis (DGGE) followed by transfer and hybridization with gene-specific probes

1988 • 44 citations

Genome scanning of higher eukaryotes by two-dimensional DNA typing using micro- and minisatellite core probes

1991 • 20 citations