Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

1980 • 28,067 citations

PHYLIP-Phylogeny inference package (Version 3.2)

1989 • 17,674 citations

Tree View: An application to display phylogenetic trees on personal computers

1996 • 10,369 citations

Selection of Conserved Blocks from Multiple Alignments for Their Use in Phylogenetic Analysis

2000 • 9,575 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

Environmental Genome Shotgun Sequencing of the Sargasso Sea

2004 • 4,313 citations

Gut flora in health and disease

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THE POPULATION FREQUENCIES OF SPECIES AND THE ESTIMATION OF POPULATION PARAMETERS

1953 • 3,155 citations

Commensal Host-Bacterial Relationships in the Gut

2001 • 2,278 citations

The species concept for prokaryotes

2001 • 1,494 citations

Direct Analysis of Genes Encoding 16S rRNA from Complex Communities Reveals Many Novel Molecular Species within the Human Gut

1999 • 1,472 citations

The Ribosomal Database Project (RDP-II): previewing a new autoaligner that allows regular updates and the new prokaryotic taxonomy

2003 • 1,428 citations

Cloning the Soil Metagenome: a Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms

2000 • 1,239 citations

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

2004 • 1,205 citations

Butyrate inhibits inflammatory responses through NFkappa B inhibition: implications for Crohn's disease

2000 • 1,196 citations

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

1974 • 1,066 citations

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

2004 • 1,052 citations

Phylogenetic Relationships of Butyrate-Producing Bacteria from the Human Gut

2000 • 885 citations

Molecular microbial diversity of an anaerobic digestor as determined by small-subunit rDNA sequence analysis

1997 • 862 citations

Culture-Independent Analysis of Gut Bacteria: the Pig Gastrointestinal Tract Microbiota Revisited

2002 • 861 citations

Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon

2003 • 733 citations

Dysbiosis in inflammatory bowel disease

2003 • 707 citations

The species concept for prokaryotes

2001 • 668 citations

Acetate Utilization and Butyryl Coenzyme A (CoA):Acetate-CoA Transferase in Butyrate-Producing Bacteria from the Human Large Intestine

2002 • 644 citations

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

1974 • 537 citations

The Population Frequencies of Species and the Estimation of Population Parameters

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Characterization of uncultivated prokaryotes: isolation and analysis of a 40-kilobase-pair genome fragment from a planktonic marine archaeon

1996 • 439 citations

Phylogenetic Analysis of the Human Gut Microbiota Using 16S rDNA Clone Libraries and Strictly Anaerobic Culture‐Based Methods

2002 • 426 citations

Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis

2002 • 370 citations

Recombinant Environmental Libraries Provide Access to Microbial Diversity for Drug Discovery from Natural Products

2003 • 351 citations

Phylogenetic and Ecological Analysis of Novel Marine Stramenopiles

2004 • 319 citations

Colonic Microbiota Signatures across Five Northern European Countries

2005 • 275 citations

Molecular inventory of faecal microflora in patients with Crohn's disease

2004 • 145 citations

Targeting enteric bacteria in treatment of inflammatory bowel diseases

2003 • 91 citations

Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis

2002 • 17 citations

Editor's quiz: GI snapshot

2007 • 15 citations

FISH (Fluorescent In Situ Hybridisation)

2001 • 1 citations