Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

Methods of Molecular Quantum Mechanics

1993 • 1,066 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

2002 • 818 citations

Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections

2002 • 725 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

2002 • 636 citations

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

2001 • 616 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

Chromosome segregation and cancer: cutting through the mystery

2001 • 459 citations

Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation

2001 • 457 citations

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

2001 • 411 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Aurora B Kinase Exists in a Complex with Survivin and INCENP and Its Kinase Activity Is Stimulated by Survivin Binding and Phosphorylation

2002 • 318 citations

Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

2002 • 308 citations

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

2001 • 261 citations

Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

1995 • 259 citations

Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

1999 • 233 citations

Structures of the Cancer-Related Aurora-A, FAK, and EphA2 Protein Kinases from Nanovolume Crystallography

2002 • 210 citations

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

1997 • 201 citations

The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

2002 • 188 citations

Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition

2005 • 141 citations

Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells

2002 • 122 citations

Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family

2002 • 117 citations

CH···O and CH···N Hydrogen Bonds in Ligand Design: A Novel Quinazolin-4-ylthiazol-2-ylamine Protein Kinase Inhibitor

2005 • 78 citations

Progress in the Development of Selective Inhibitors of Aurora Kinases

2005 • 75 citations

Integrating Functions at the Kinetochore

2002 • 12 citations

A facile nucleophilic displacement of bromine in 2-amino-4-methyl-5-bromothiazole by a thiophenoxide anion

1967 • 9 citations

Zur Synthese von 2‐Amino‐thiazolderivaten

1955 • 5 citations

Pictures in cell biology

2001 • 2 citations