Cerebroprotective Effect of the Nitric Oxide Synthase Inhibitors, 1-(2-Trifluoromethylphenyl) Imidazole and 7-Nitro Indazole, after Transient Focal Cerebral Ischemia in the Rat

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Experimental studies of ischemic brain edema

1986 • 932 citations

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 770 citations

Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

1994 • 669 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia

1995 • 479 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

Nitric oxide-induced blockade of NMDA receptors

1992 • 455 citations

7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure

1993 • 426 citations

Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase after Transient MCA Occlusion

1996 • 422 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

1995 • 378 citations

Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

1993 • 371 citations

Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.

1991 • 331 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 294 citations

The Effect of Hypothermia on Transient Middle Cerebral Artery Occlusion in the Rat

1992 • 276 citations

L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.

1994 • 233 citations

Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia

1994 • 206 citations

Aminoguanidine Ameliorates and <scp>l</scp> -Arginine Worsens Brain Damage From Intraluminal Middle Cerebral Artery Occlusion

1996 • 184 citations

The Complex Role of Nitric Oxide in the Pathophysiology of Focal Cerebral Ischemia

1994 • 176 citations

Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

1993 • 171 citations

ARL 17477, a Potent and Selective Neuronal NOS Inhibitor Decreases Infarct Volume after Transient Middle Cerebral Artery Occlusion in Rats

1996 • 163 citations

Nitroprusside improves blood flow and reduces brain damage after focal ischemia

1993 • 145 citations

Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome.

1994 • 144 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Dual role of nitric oxide in focal cerebral ischemia

1994 • 141 citations

L-arginine decreases infarct size caused by middle cerebral arterial occlusion in SHR

1992 • 123 citations

<scp>l</scp>‐Arginine dilates rat pial arterioles by nitric oxide‐dependent mechanisms and increases blood flow during focal cerebral ischaemia

1992 • 120 citations

Reduction of Focal Cerebral Ischemic Damage by Delayed Treatment with Nitric Oxide Donors

1994 • 106 citations

The antinociceptive effect of 1‐(2‐trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse

1995 • 98 citations

Elevation of Plasma Nitric Oxide End Products during Focal Cerebral Ischemia and Reperfusion in the Rat

1994 • 89 citations

Inhibition of nitric oxide synthase by 1‐(2‐trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects

1996 • 86 citations

Low Dose L-NAME Reduces Infarct Volume in the Rat MCAO/Reperfusion Model

1993 • 76 citations

Anticonvulsant effects of 7‐nitroindazole in rodents with reflex epilepsy may result from L‐arginine accumulation or a reduction in nitric oxide or L‐citrulline formation

1996 • 69 citations

L-Arginine Does Not Improve Cortical Perfusion or Histopathological Outcome in Spontaneously Hypertensive Rats Subjected to Distal Middle Cerebral Artery Photothrombotic Occlusion

1996 • 30 citations

The role of nitric oxide in ischemic damage.

1996 • 10 citations

Delayed treatment of reversible focal cerebral ischaemia with 7-nitroindazole in rats

1996 • 2 citations

Announcement

1995 • 2 citations