Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

Rodent models of cerebral ischemia.

1989 • 663 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

<scp>l</scp>‐N^G‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse

1991 • 481 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure

1993 • 426 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

1993 • 371 citations

Nitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and

1991 • 368 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Selective neuronal death after transient forebrain ischemia in the mongolian gerbil: A silver impregnation study

1988 • 298 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

1992 • 239 citations

Nitric oxide: foe or friend to the injured brain?

1993 • 212 citations

Aminoguanidine Ameliorates and <scp>l</scp> -Arginine Worsens Brain Damage From Intraluminal Middle Cerebral Artery Occlusion

1996 • 184 citations

Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

1993 • 171 citations

Pharmacology of cerebral ischemia

1995 • 163 citations

Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome.

1994 • 144 citations

Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man.

1992 • 142 citations

Dual role of nitric oxide in focal cerebral ischemia

1994 • 141 citations

Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia

1992 • 119 citations

Neuroprotective Effect of the AMPA Receptor Antagonist LY-293558 in Focal Cerebral Ischemia in the Cat

1994 • 85 citations

enhances neuronal death following transient forebrain ischemia in gerbils

1992 • 81 citations

Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion

1995 • 76 citations

The neuroprotective effect of a potent and selective inhibitor of type I NOS (L-MIN) in a rat model of focal cerebral ischaemia

1995 • 56 citations

Nitric oxide synthase inhibitorNG-nitro-l-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats

1995 • 55 citations

Anti‐ischaemic efficacy of a nitric oxide synthase inhibitor and a N‐methyl‐<scp>d</scp>‐aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia

1994 • 53 citations

Expression of Inducible Nitric Oxide Synthase in Cerebral Endothelial Cells Is Regulated by Cytokine‐Activated Astrocytes

1995 • 51 citations

Nitric oxide synthase in cerebral ischemia

1995 • 50 citations

protects against ischaemia-induced increases in nitric oxide and hippocampal neuro-degeneration in the gerbil

1994 • 44 citations

The σ receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia

1995 • 32 citations

NG-nitro-l-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia

1995 • 22 citations

Intraventricular administration of nitric oxide synthase inhibitors prevents delayed neuronal death in gerbil hippocampal CA 1 neurons

1995 • 20 citations

Pharmacological Strategies in the Treatment of Cerebral Ischemia

1995 • 8 citations

Changes in nitric oxide generation in rats with global ischemia : in vivo measurement using a nitric oxide sensor

1995 • 4 citations

Bilateral Obstruction of the Vertebral Arteries

1970 • 3 citations