Endothelin-1 induced middle cerebral artery occlusion: pathological consequences and neuroprotective effects of MK801

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1981 • 1,420 citations

Rodent models of cerebral ischemia.

1989 • 663 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age

1988 • 393 citations

Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 385 citations

Focal Cerebral Ischaemia in the Rat: 2. Regional Cerebral Blood Flow Determined by [¹⁴C]Iodoantipyrine Autoradiography following Middle Cerebral Artery Occlusion

1981 • 306 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia

1988 • 244 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

Endothelin-1-Induced Reductions in Cerebral Blood Flow: Dose Dependency, Time Course, and Neuropathological Consequences

1993 • 226 citations

A new model of temporary focal neocortical ischemia in the rat.

1992 • 225 citations

Treatment of Experimental Cerebral Ischemia

1982 • 224 citations

Perivascular Microapplication of Endothelin-1: A New Model of Focal Cerebral Ischaemia in the Rat

1993 • 224 citations

Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor antagonist.

1993 • 217 citations

Experimental ischemic stroke: a review.

1984 • 213 citations

High‐dose barbiturate therapy in humans: A clinical review of 60 patients

1979 • 192 citations

Kynurenate inhibition of cell excitation decreases stroke size and deficits

1987 • 189 citations

Hyperglycemia Increases Infarct Size in Collaterally Perfused but Not End-Arterial Vascular Territories

1988 • 178 citations

BARBITURATES IN BRAIN ISCHAEMIA

1985 • 156 citations

N‐Methyl‐D‐Aspartate antagonist reduces stroke size and regional glucose metabolism

1990 • 155 citations

The pharmacotherapy of focal cortical ischaemia in the mouse

1990 • 151 citations

Nimodipine and the Haemodynamic and Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat

1986 • 147 citations

Recirculation model following MCA occlusion in rats

1985 • 137 citations

Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat

1992 • 121 citations

Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat

1990 • 115 citations

A Classification of Experimental Models of Brain Ischemia

1976 • 115 citations

Barbiturate-induced coma therapy for focal cerebral ischemia

1981 • 106 citations

A mouse model of focal cerebral ischemia for screening neuroprotective drug effects

1992 • 91 citations

Ischemic brain edema: comparative effects of barbiturates and hypothermia.

1979 • 80 citations

THE PATHOLOGY OF BRAIN ISCHAEMIA AND POSSIBILITIES FOR THERAPEUTIC INTERVENTION

1985 • 68 citations

Endothelin-1 Acts in Cerebral Arteries from the Adventitial but Not from the Luminal Side

1989 • 64 citations

Protection from cerebral ischemia by a new imidazole derivative (Y-9179) and pentobarbital. A comparative study in chronic middle cerebral artery occlusion in cats.

1979 • 59 citations

Sample size and power for comparing two or more treatment groups in clinical trials.

1989 • 49 citations

DRUG THERAPY IN BRAIN ISCHAEMIA

1985 • 45 citations

The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury

1989 • 39 citations

Differential effects of intra- and extraluminal endothelin on cerebral arterioles

1991 • 38 citations

Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats.

1991 • 33 citations

Focal Cerebral Infarction

1988 • 31 citations

The effect of lifarizine (RS‐87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil

1993 • 23 citations

Endothelin-I—mediated vasoconstriction: Specific blockade by verapamil

1992 • 17 citations

Experimental Cerebral Ischemia: Barbiturate Resistant Increase in Regional Glucose Utilization

1988 • 17 citations

Comparison of Vasoconstrictor Actions of Endothelin-1 in Cerebral, Coronary, and Mesenteric Arteries of the Dog

1992 • 14 citations