Back to search

Role of nitric oxide in traumatic brain injury in the rat

Data up to Jan 2025

Published1998
Citations165
References122

Total Citations Per Year

Abstract

References (122)

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

1990 • 1,080 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

A fluid percussion model of experimental brain injury in the rat

1987 • 1,031 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

The Cortex of the Rat

1985 • 757 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia

1991 • 726 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Responses to cortical injury: I. Methodology and local effects of contusions in the rat

1981 • 691 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

1994 • 669 citations

Nitric Oxide Synthase in Models of Focal Ischemia

1997 • 659 citations

The Cortex of the Rat: A Stereotaxic Atlas

1985 • 658 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Glutamate Release and Free Radical Production Following Brain Injury: Effects of Posttraumatic Hypothermia

1995 • 616 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury

1991 • 529 citations

Changes in Cortical Extracellular Levels of Energy-Related Metabolites and Amino Acids following Concussive Brain Injury in Rats

1990 • 521 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

Nitric oxide neurotoxicity

1996 • 496 citations

The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators

1991 • 478 citations

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography.

1993 • 467 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Ischaemic brain damage in fatal non-missile head injuries

1978 • 450 citations

Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model

1993 • 409 citations

Possible Origins and Distribution of Immunoreactive Nitric Oxide Synthase-Containing Nerve Fibers in Cerebral Arteries

1993 • 382 citations

Early Microvascular and Neuronal Consequences of Traumatic Brain Injury: A Light and Electron Microscopic Study in Rats

1994 • 357 citations

Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat

1994 • 304 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection.

1993 • 294 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats.

1980 • 290 citations

Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema

1987 • 283 citations

Oxygen in mammalian tissue: methods of measurement and affinities of various reactions

1991 • 278 citations

Nitric oxide production during focal cerebral ischemia in rats.

1993 • 272 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain

1980 • 252 citations

Organic nitrate esters: clinical use and mechanisms of actions.

1991 • 234 citations

Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a Phase II trial

1993 • 234 citations

L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.

1994 • 233 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia

1995 • 220 citations

High-dose glucocorticoid treatment improves neurological recovery in head-injured mice

1985 • 219 citations

Vascular permeability alterations to horseradish peroxidase in experimental brain injury

1978 • 219 citations

Delayed Posttraumatic Brain Hyperthermia Worsens Outcome after Fluid Percussion Brain Injury: A Light and Electron Microscopic Study in Rats

1996 • 216 citations

Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres

1989 • 216 citations

Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat

1992 • 207 citations

Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia

1994 • 206 citations

Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation

1991 • 199 citations

Regulation of nitric oxide synthase by nitric oxide.

1993 • 197 citations

Nitric Oxide in the Central Nervous System

1995 • 187 citations

Breakdown of the Blood–Brain Barrier after Fluid Percussive Brain Injury in the Rat. Part 1: Distribution and Time Course of Protein Extravasation

1992 • 187 citations

Effects of theN-Methyl-<scp>d</scp>-Aspartate Receptor Blocker MK-801 on Neurologic Function After Experimental Brain Injury

1989 • 183 citations

Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.

1993 • 182 citations

Alterations in Regional Cerebral Blood Flow following Brain Injury in the Rat

1991 • 175 citations

U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia.

1991 • 145 citations

Nitroprusside improves blood flow and reduces brain damage after focal ischemia

1993 • 145 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Dual role of nitric oxide in focal cerebral ischemia

1994 • 141 citations

Characterization of endothelium-derived relaxing factor/nitric oxide synthase from bovine cerebellum and mechanism of modulation by high and low oxygen tensions.

1991 • 140 citations

Effects of fluid-percussion brain injury on regional cerebral blood flow and pial arteriolar diameter

1986 • 139 citations

Endothelium-derived nitric oxide synthase inhibition. Effects on cerebral blood flow, pial artery diameter, and vascular morphology in rats.

1992 • 138 citations

Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.

1993 • 131 citations

Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury

1993 • 128 citations

Relationship between body and brain temperature in traumatically brain-injured rodents

1991 • 126 citations

Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization

1992 • 120 citations

<scp>l</scp>‐Arginine dilates rat pial arterioles by nitric oxide‐dependent mechanisms and increases blood flow during focal cerebral ischaemia

1992 • 120 citations

L-Arginine and Superoxide Dismutase Prevent or Reverse Cerebral Hypoperfusion after Fluid-Percussion Traumatic Brain Injury

1997 • 113 citations

Importance of Nitric Oxide Synthase Inhibition to the Attenuated Vascular Responses Induced by Topical L-Nitroarginine during Vibrissal Stimulation

1994 • 110 citations

Posttraumatic Cerebral Ischemia after Fluid Percussion Brain Injury: An Autoradiographic and Histopathological Study in Rats

1998 • 105 citations

Therapeutic Hypothermia Is Cytoprotective without Attenuating the Traumatic Brain Injury-Induced Elevations in Interstitial Concentrations of Aspartate and Glutamate

1993 • 102 citations

Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors

1996 • 100 citations

Widespread Hemodynamic Depression and Focal Platelet Accumulation after Fluid Percussion Brain Injury: A Double-Label Autoradiographic Study in Rats

1996 • 99 citations

Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells

1991 • 98 citations

Direct and reversible inhibition of endothelial nitric oxide synthase by nitric oxide

1995 • 97 citations

Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF

1990 • 89 citations

Elevation of Plasma Nitric Oxide End Products during Focal Cerebral Ischemia and Reperfusion in the Rat

1994 • 89 citations

Posttreatment with Intravenous Basic Fibroblast Growth Factor Reduces Histopathological Damage Following Fluid-Percussion Brain Injury in Rats

1996 • 87 citations

Micro vascular alterations following cerebral contusion in rats

1985 • 85 citations

Kynurenate is neuroprotective following experimental brain injury in the rat

1994 • 79 citations

The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat

1997 • 79 citations

Ketamine Antagonizes Nitric Oxide Release From Cerebral Cortex After Middle Cerebral Artery Ligation in Rats

1996 • 76 citations

Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase

1995 • 68 citations

Recent Advances in Neuropathology

1983 • 64 citations

Effects of Mild Hypothermia on Nitric Oxide Synthesis Following Contusion Trauma in the Rat

1997 • 63 citations

Effects of Nitric Oxide Synthase Inhibition on Cerebral Blood Flow following Bilateral Carotid Artery Occlusion and Recirculation in the Rat

1993 • 59 citations

Combined effect of respirator-induced ventilation and superoxide dismutase in experimental brain injury

1989 • 55 citations

Overview of Monitoring of Cerebral Blood Flow and Metabolism after Severe Head Injury

1994 • 51 citations

Chapter 14 Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia

1996 • 39 citations

Changes in the choroid plexus, responses by intrinsic epiplexus cells and recruitment from monocytes after experimental head acceleration injury in the non-human primate

1992 • 38 citations

l-Arginine ameliorates cerebral blood flow and metabolism and decreases infarct volume in rats with cerebral ischemia

1995 • 33 citations

L-Arginine Does Not Improve Cortical Perfusion or Histopathological Outcome in Spontaneously Hypertensive Rats Subjected to Distal Middle Cerebral Artery Photothrombotic Occlusion

1996 • 30 citations

Delayed Posttraumatic Brain Hyperthermia Worsens Outcome after Fluid Percussion Brain Injury: A Light and Electron Microscopic Study in Rats

1996 • 30 citations

An ultrastructural study of experimental high velocity penetrating head injury

1983 • 26 citations

l-Arginine ameliorates recirculation and metabolic derangement in brain ischemia in hypertensive rats

1997 • 24 citations

Different mechanisms of l-arginine induced dilation of brain arterioles in normotensive and hypertensive rats

1995 • 21 citations

Nitric oxide and cerebral ischemia.

1996 • 15 citations

Cited By (0)

Loading...
Role of nitric oxide in traumatic brain injury in the rat (1998) – Journal of neurosurgery | Metascience Observatory Explorer