Role of nitric oxide in traumatic brain injury in the rat
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References (122)
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 • 225,752 citations
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 • 200,127 citations
Nitric oxide: physiology, pathophysiology, and pharmacology.
1991 • 15,563 citations
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
1987 • 10,774 citations
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
1990 • 7,068 citations
The L-Arginine-Nitric Oxide Pathway
1993 • 6,737 citations
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
1996 • 5,498 citations
Vascular endothelial cells synthesize nitric oxide from L-arginine
1988 • 4,800 citations
Nitric oxide as a secretory product of mammalian cells
1992 • 4,437 citations
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
1990 • 3,304 citations
Nitric oxide: an endogenous modulator of leukocyte adhesion.
1991 • 3,079 citations
Glutamate, nitric oxide and cell-cell signalling in the nervous system
1991 • 2,406 citations
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
1991 • 2,173 citations
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
1989 • 1,850 citations
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase
1994 • 1,578 citations
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
1989 • 1,505 citations
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
1989 • 1,443 citations
Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase
1991 • 1,364 citations
Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
1990 • 1,080 citations
Bright and dark sides of nitric oxide in ischemic brain injury
1997 • 1,043 citations
A fluid percussion model of experimental brain injury in the rat
1987 • 1,031 citations
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
1993 • 1,024 citations
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
1991 • 982 citations
The Cortex of the Rat
1985 • 757 citations
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.
1996 • 730 citations
Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia
1991 • 726 citations
Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine
1996 • 713 citations
Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide
1992 • 702 citations
Responses to cortical injury: I. Methodology and local effects of contusions in the rat
1981 • 691 citations
The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation
1985 • 685 citations
Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation
1994 • 669 citations
Nitric Oxide Synthase in Models of Focal Ischemia
1997 • 659 citations
The Cortex of the Rat: A Stereotaxic Atlas
1985 • 658 citations
Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.
1994 • 658 citations
The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway
1992 • 654 citations
Calmodulin is a subunit of nitric oxide synthase from macrophages.
1992 • 640 citations
Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.
1992 • 622 citations
Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.
1992 • 621 citations
Glutamate Release and Free Radical Production Following Brain Injury: Effects of Posttraumatic Hypothermia
1995 • 616 citations
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.
1993 • 543 citations
Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury
1991 • 529 citations
Changes in Cortical Extracellular Levels of Energy-Related Metabolites and Amino Acids following Concussive Brain Injury in Rats
1990 • 521 citations
Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse
1991 • 509 citations
Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin
1990 • 507 citations
Nitric oxide neurotoxicity
1996 • 496 citations
The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators
1991 • 478 citations
Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography.
1993 • 467 citations
Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.
1991 • 458 citations
Ischaemic brain damage in fatal non-missile head injuries
1978 • 450 citations
Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model
1993 • 409 citations
Possible Origins and Distribution of Immunoreactive Nitric Oxide Synthase-Containing Nerve Fibers in Cerebral Arteries
1993 • 382 citations
Early Microvascular and Neuronal Consequences of Traumatic Brain Injury: A Light and Electron Microscopic Study in Rats
1994 • 357 citations
Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat
1994 • 304 citations
The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels
1994 • 298 citations
Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection.
1993 • 294 citations
Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors
1995 • 292 citations
Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats.
1980 • 290 citations
Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema
1987 • 283 citations
Oxygen in mammalian tissue: methods of measurement and affinities of various reactions
1991 • 278 citations
Nitric oxide production during focal cerebral ischemia in rats.
1993 • 272 citations
Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine
1992 • 254 citations
Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain
1980 • 252 citations
Organic nitrate esters: clinical use and mechanisms of actions.
1991 • 234 citations
Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a Phase II trial
1993 • 234 citations
L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.
1994 • 233 citations
Brain Hydroxyl Radical Generation in Acute Experimental Head Injury
1993 • 226 citations
Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia
1995 • 220 citations
High-dose glucocorticoid treatment improves neurological recovery in head-injured mice
1985 • 219 citations
Vascular permeability alterations to horseradish peroxidase in experimental brain injury
1978 • 219 citations
Delayed Posttraumatic Brain Hyperthermia Worsens Outcome after Fluid Percussion Brain Injury: A Light and Electron Microscopic Study in Rats
1996 • 216 citations
Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres
1989 • 216 citations
Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat
1992 • 207 citations
Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia
1994 • 206 citations
Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation
1991 • 199 citations
Regulation of nitric oxide synthase by nitric oxide.
1993 • 197 citations
Nitric Oxide in the Central Nervous System
1995 • 187 citations
Breakdown of the Blood–Brain Barrier after Fluid Percussive Brain Injury in the Rat. Part 1: Distribution and Time Course of Protein Extravasation
1992 • 187 citations
Effects of theN-Methyl-<scp>d</scp>-Aspartate Receptor Blocker MK-801 on Neurologic Function After Experimental Brain Injury
1989 • 183 citations
Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.
1993 • 182 citations
Alterations in Regional Cerebral Blood Flow following Brain Injury in the Rat
1991 • 175 citations
U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia.
1991 • 145 citations
Nitroprusside improves blood flow and reduces brain damage after focal ischemia
1993 • 145 citations
Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats
1992 • 142 citations
Dual role of nitric oxide in focal cerebral ischemia
1994 • 141 citations
Characterization of endothelium-derived relaxing factor/nitric oxide synthase from bovine cerebellum and mechanism of modulation by high and low oxygen tensions.
1991 • 140 citations
Effects of fluid-percussion brain injury on regional cerebral blood flow and pial arteriolar diameter
1986 • 139 citations
Endothelium-derived nitric oxide synthase inhibition. Effects on cerebral blood flow, pial artery diameter, and vascular morphology in rats.
1992 • 138 citations
Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.
1993 • 131 citations
Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury
1993 • 128 citations
Relationship between body and brain temperature in traumatically brain-injured rodents
1991 • 126 citations
Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization
1992 • 120 citations
<scp>l</scp>‐Arginine dilates rat pial arterioles by nitric oxide‐dependent mechanisms and increases blood flow during focal cerebral ischaemia
1992 • 120 citations
L-Arginine and Superoxide Dismutase Prevent or Reverse Cerebral Hypoperfusion after Fluid-Percussion Traumatic Brain Injury
1997 • 113 citations
Importance of Nitric Oxide Synthase Inhibition to the Attenuated Vascular Responses Induced by Topical L-Nitroarginine during Vibrissal Stimulation
1994 • 110 citations
Posttraumatic Cerebral Ischemia after Fluid Percussion Brain Injury: An Autoradiographic and Histopathological Study in Rats
1998 • 105 citations
Therapeutic Hypothermia Is Cytoprotective without Attenuating the Traumatic Brain Injury-Induced Elevations in Interstitial Concentrations of Aspartate and Glutamate
1993 • 102 citations
Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors
1996 • 100 citations
Widespread Hemodynamic Depression and Focal Platelet Accumulation after Fluid Percussion Brain Injury: A Double-Label Autoradiographic Study in Rats
1996 • 99 citations
Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells
1991 • 98 citations
Direct and reversible inhibition of endothelial nitric oxide synthase by nitric oxide
1995 • 97 citations
Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF
1990 • 89 citations
Elevation of Plasma Nitric Oxide End Products during Focal Cerebral Ischemia and Reperfusion in the Rat
1994 • 89 citations
Posttreatment with Intravenous Basic Fibroblast Growth Factor Reduces Histopathological Damage Following Fluid-Percussion Brain Injury in Rats
1996 • 87 citations
Micro vascular alterations following cerebral contusion in rats
1985 • 85 citations
Kynurenate is neuroprotective following experimental brain injury in the rat
1994 • 79 citations
The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat
1997 • 79 citations
Ketamine Antagonizes Nitric Oxide Release From Cerebral Cortex After Middle Cerebral Artery Ligation in Rats
1996 • 76 citations
Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase
1995 • 68 citations
Recent Advances in Neuropathology
1983 • 64 citations
Effects of Mild Hypothermia on Nitric Oxide Synthesis Following Contusion Trauma in the Rat
1997 • 63 citations
Effects of Nitric Oxide Synthase Inhibition on Cerebral Blood Flow following Bilateral Carotid Artery Occlusion and Recirculation in the Rat
1993 • 59 citations
Combined effect of respirator-induced ventilation and superoxide dismutase in experimental brain injury
1989 • 55 citations
Overview of Monitoring of Cerebral Blood Flow and Metabolism after Severe Head Injury
1994 • 51 citations
Chapter 14 Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia
1996 • 39 citations
Changes in the choroid plexus, responses by intrinsic epiplexus cells and recruitment from monocytes after experimental head acceleration injury in the non-human primate
1992 • 38 citations
l-Arginine ameliorates cerebral blood flow and metabolism and decreases infarct volume in rats with cerebral ischemia
1995 • 33 citations
L-Arginine Does Not Improve Cortical Perfusion or Histopathological Outcome in Spontaneously Hypertensive Rats Subjected to Distal Middle Cerebral Artery Photothrombotic Occlusion
1996 • 30 citations
Delayed Posttraumatic Brain Hyperthermia Worsens Outcome after Fluid Percussion Brain Injury: A Light and Electron Microscopic Study in Rats
1996 • 30 citations
An ultrastructural study of experimental high velocity penetrating head injury
1983 • 26 citations
l-Arginine ameliorates recirculation and metabolic derangement in brain ischemia in hypertensive rats
1997 • 24 citations
Different mechanisms of l-arginine induced dilation of brain arterioles in normotensive and hypertensive rats
1995 • 21 citations
Nitric oxide and cerebral ischemia.
1996 • 15 citations