Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

MicroRNAs: small RNAs with a big role in gene regulation

2004 • 6,733 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

Rational siRNA design for RNA interference

2004 • 1,991 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Lentivirus-delivered stable gene silencing by RNAi in primary cells

2003 • 1,484 citations

Activation of the interferon system by short-interfering RNAs

2003 • 1,416 citations

siRNAs can function as miRNAs

2003 • 1,252 citations

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

2005 • 1,177 citations

Unlocking the potential of the human genome with RNA interference

2004 • 1,066 citations

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

2004 • 1,057 citations

Perspective: machines for RNAi

2005 • 942 citations

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

2004 • 898 citations

Inhibition of respiratory viruses by nasally administered siRNA

2004 • 725 citations

Antisense oligonucleotides: basic concepts and mechanisms.

2002 • 719 citations

A resource for large-scale RNA-interference-based screens in mammals

2004 • 685 citations

Cre-lox-regulated conditional RNA interference from transgenes

2004 • 617 citations

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

2002 • 561 citations

In vivo activity of nuclease-resistant siRNAs

2004 • 551 citations

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA

2003 • 547 citations

Sequence requirements for micro RNA processing and function in human cells

2003 • 538 citations

Nucleic-acid therapeutics: basic principles and recent applications

2002 • 523 citations

Specificity of short interfering RNA determined through gene expression signatures

2003 • 497 citations

Small RNAs Make Big Splash

2002 • 487 citations

Approaches for the sequence-specific knockdown of mRNA

2003 • 444 citations

Functional Anatomy of a dsRNA Trigger

2000 • 397 citations

Noise amidst the silence: off-target effects of siRNAs?

2004 • 360 citations

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

2003 • 343 citations

RNA interference and chemically modified small interfering RNAs

2004 • 340 citations

Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer

2004 • 324 citations

siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference

2004 • 275 citations

Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins

2004 • 231 citations

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

2004 • 226 citations

The rest is silence.

2001 • 214 citations

Defining and Assaying RNAi in Mammalian Cells

2005 • 167 citations

Determinants of interferon-stimulated gene induction by RNAi vectors

2004 • 164 citations

Cell-biological applications of transfected-cell microarrays

2002 • 146 citations

Plant Pathology and RNAi: A Brief History

2005 • 142 citations

RNA Interference

2000 • 101 citations

Mechanistic Insights Aid Computational Short Interfering RNA Design

2005 • 69 citations

Ribozymes, genomics and therapeutics

1999 • 63 citations

Knockdown of Hepatic ABCA1 by RNA Interference Decreases Plasma HDL Cholesterol Levels and Influences Postprandial Lipemia in Mice

2005 • 57 citations

RNA interference mediated in human primary cells via recombinant baculoviral vectors

2005 • 55 citations

HuSiDa--the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells

2004 • 50 citations

Oncology studies using siRNA libraries: the dawn of RNAi-based genomics

2004 • 50 citations

RNAi knock-down mice: an emerging technology for post-genomic functional genetics

2004 • 46 citations

Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research

2004 • 44 citations

Towards Therapy Using RNA Interference

2004 • 40 citations

Picking a winner: new mechanistic insights into the design of effective siRNAs

2004 • 35 citations

Induction of RNA interference using short interfering RNA expression vectors in cell culture and animal systems.

2003 • 21 citations

Silence of the genes

2004 • 17 citations