siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference

Basic local alignment search tool

1990 • 87,358 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Identification of common molecular subsequences

1981 • 9,753 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

RNA interference

2002 • 3,369 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

Expression profiling reveals off-target gene regulation by RNAi

2003 • 2,294 citations

Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi

2002 • 1,422 citations

Killing the messenger: short RNAs that silence gene expression

2003 • 1,197 citations

Stable suppression of tumorigenicity by virus-mediated RNA interference

2002 • 1,147 citations

Database resources of the National Center for Biotechnology

2003 • 1,110 citations

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

2004 • 742 citations

Allele-specific silencing of dominant disease genes

2003 • 395 citations

Mammalian RNAi for the masses

2002 • 284 citations

Short-Interfering-RNA-Mediated Gene Silencing in Mammalian Cells Requires Dicer and eIF2C Translation Initiation Factors

2003 • 224 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 210 citations

Nucleic Acid-Based Immune System: the Antiviral Potential of Mammalian RNA Silencing

2003 • 139 citations

Dissecting HIV-1 through RNA interference

2003 • 67 citations

A Web-based design center for vector-based siRNA and siRNA cassette

2004 • 66 citations

Gene specific siRNA selector

2004 • 35 citations

COMPUTING HIGHLY SPECIFIC AND NOISE-TOLERANT OLIGOMERS EFFICIENTLY

2004 • 10 citations