Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England.

1961 • 812 citations

Ia antigen expression on human epidermal Langerhans cells

1977 • 603 citations

Dendritic Cells: Features and Functions

1980 • 585 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Reactivity of Langerhans cells with hybridoma antibody.

1981 • 560 citations

Epidermal Langerhans cells bear Fc and C3 receptors

1977 • 541 citations

Epidermal Langerhans cells express Ia antigens

1977 • 493 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice

1983 • 367 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.

1983 • 300 citations

Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

1981 • 292 citations

Accessory and stimulating properties of dendritic cells and macrophages isolated from various rat tissues

1982 • 252 citations

A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions.

1988 • 248 citations

Langerhans Cell Production of Interleukin-1

1984 • 233 citations

Human dendritic cells and macrophages. In situ immunophenotypic definition of subsets that exhibit specific morphologic and microenvironmental characteristics.

1985 • 231 citations

The skin immune system Its cellular constituents and their interactions

1986 • 227 citations

Regulatory properties of LFA-1 α and β chains in human T-lymphocyte activation

1988 • 225 citations

IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines.

1989 • 205 citations

Discrimination of Human Macrophages and Dendritic Cells by Means of Monoclonal Antibodies

1986 • 199 citations

Relation between Langerhans Cells, Veiled Cells, and Interdigitating Cells

1982 • 194 citations

Immunohistological detection of interleukin 1-like molecules and tumour necrosis factor in human epidermis before and after UVB-irradiation in vivo

1988 • 190 citations

The Langerhans Cell1

2015 • 172 citations

The langerhans cell.

1972 • 167 citations

Immunohistological analysis of human mononuclear phagocytes and dendritic cells by using monoclonal antibodies.

1986 • 165 citations

T6 Is Superior to Ia (HLA-DR) As a Marker for Langerhans Cells and Indeterminate Cells in Normal Epidermis: A Monoclonal Antibody Study

1983 • 164 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Epidermal cells synthesize a cytokine with interleukin 3-like properties.

1985 • 145 citations

Phenotypic transformation of macrophages to Langerhans cells in the skin.

1986 • 134 citations

The expression and modulation of IL-1 alpha in murine keratinocytes.

1988 • 123 citations

Inhibition of the Induction of Contact Hypersensitivity by a UV-Mediated Epidermal Cytokine

1986 • 103 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Keratinocyte Derived T-Cell Growth Factor (KTGF) Is Identical to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)

1988 • 102 citations

Modulation of Expression of Epidermal Langerhans Cell Properties Following in Situ Exposure to Glucocorticosteroids

1983 • 90 citations

Nickel‐specific T lymphocyte clones derived from allergic nickel‐contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen‐presenting cell subsets

1987 • 88 citations

Human epidermal Langerhans cells are more potent than blood monocytes in inducing some antigen-specific T-cell responses

1983 • 87 citations

Interaction of CD2 with its ligand, LFA-3, in human T cell proliferation.

1988 • 87 citations

Abolition of specific immune response defect by immunization with dendritic cells

1985 • 68 citations

Enriched Epidermal Langerhans Cells Are Potent Antigen-Presenting Cells for T Cells

1984 • 62 citations

Human cutaneous dendritic cells express two glycoproteins T6 and M241 which are biochemically identical to those found on cortical thymocytes

1984 • 53 citations

The Crucial Role of Human Dendritic Antigen-Presenting Cell Subsets in Nickel-Specific T-Cell Proliferation

1987 • 45 citations

HLA-D Region Antigen Expression by Human Epidermal Langerhans Cells

1986 • 42 citations

Immunostimulatory Capabilities of Highly Enriched Langerhans Cells In Vitro

1988 • 35 citations

Interleukin 1 Induces CD1 Antigen Expression on Human Gingival Epithelial Cells

1988 • 30 citations

Modulation of gingival Langerhans cell T6 antigen expression in vitro by interleukin 1 and an interleukin 1 inhibitor.

1986 • 28 citations

Enrichment of Unlabeled Human Langerhans Cells from Epidermal Cell Suspensions by Discontinuous Density Gradient Centrifugation

1988 • 27 citations

Location of HLA-A,B,C Antigens in Dendritic Cells of Normal Human Skin: An Immunoelectron Microscopic Study

1983 • 26 citations

Subclustering of CD1 monoclonal antibodies based on the reactivity on human langerhans cells

1986 • 22 citations

Enzyme cytochemistry of unfixed leukocytes and bone marrow cells using polyvinyl alcohol for the diagnosis of leukemia

1989 • 14 citations

Isolation and Preliminary Biochemical Characterization of the Human Epidermal Langerhans Cell

1985 • 13 citations