Thiazolidinedione Induces Apoptosis and Monocytic Differentiation in the Promyelocytic Leukemia Cell Line HL60

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

1996 • 1,004 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

1997 • 655 citations

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

1996 • 638 citations

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1997 • 614 citations

Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters

1979 • 594 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1996 • 583 citations

Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

1995 • 397 citations

Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

1995 • 332 citations

Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.

1996 • 288 citations

Mechanisms of Bcl-2 family protein function and dysfunction in health and disease.

1996 • 99 citations

Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

1995 • 99 citations

Granulocytic differentiation of HL‐60 cells results in spontaneous apoptosis mediated by increased caspase expression

1997 • 79 citations

The Expression of Bcl-x Is Downregulated During Differentiation of Human Hematopoietic Progenitor Cells Along the Granulocyte But Not the Monocyte/Macrophage Lineage

1997 • 75 citations

Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL.

1997 • 37 citations

Action Mechanism of Retinoid-Synergistic Dibenzodiazepines

1997 • 36 citations

Increased resistance to apoptosis associated with HL-60 myeloid differentiation status.

1994 • 19 citations

Potentiating effects of clofibric acid on the differentiation of HL-60 human promyelocytic leukemia cells induced by retinoids.

1995 • 14 citations

3,5,3′-Triiodo-l-Thyronine PotentiatesAll-Trans-Retinoic Acid-Induced Apoptosis during Differentiation of the Promyeloleukemic Cell HL-60

1997 • 8 citations