Human C-reactive protein: expression, structure, and function

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men

1999 • 1,952 citations

Production of C-reactive protein and risk of coronary events in stable and unstable angina

1997 • 1,515 citations

SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS

1930 • 1,460 citations

Markers of Myocardial Damage and Inflammation in Relation to Long-Term Mortality in Unstable Coronary Artery Disease

2000 • 1,220 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages

2001 • 853 citations

The physiological structure of human C-reactive protein and its complex with phosphocholine

1999 • 790 citations

C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

2000 • 681 citations

C-Reactive Protein in the Arterial Intima

2000 • 590 citations

Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.

1974 • 561 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

C-Reactive Protein and Complement Are Important Mediators of Tissue Damage in Acute Myocardial Infarction

1999 • 506 citations

Structure of pentameric human serum amyloid P component

1994 • 459 citations

Specificity of C-Reactive Protein for Choline Phosphate Residues of Pneumococcal C-Polysaccharide

1971 • 396 citations

The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II

1999 • 382 citations

Three dimensional structure of human C-reactive protein

1996 • 355 citations

Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men

1999 • 350 citations

Pulmonary aspergillosis: Diagnostic and immunological significance of antigens and C‐substance in Aspergillus fumigatus

1964 • 347 citations

Regulation of complement activation by C-reactive protein

1999 • 316 citations

STAT3 Participates in Transcriptional Activation of the C-reactive Protein Gene by Interleukin-6

1996 • 289 citations

COMPLEMENT ACTIVATION BY C‐REACTIVE PROTEIN COMPLEXES*

1982 • 288 citations

Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae

1997 • 258 citations

Interaction of C-reactive protein with artificial phosphatidylcholine bilayers

1979 • 235 citations

Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice.

1995 • 206 citations

Regulation of Complement Activation by C-Reactive Protein: Targeting the Complement Inhibitory Activity of Factor H by an Interaction with Short Consensus Repeat Domains 7 and 8–11

1999 • 199 citations

C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding

1999 • 194 citations

Expression of C-reactive protein by alveolar macrophages.

1996 • 193 citations

A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells

1997 • 186 citations

Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate

1968 • 184 citations

Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component.

1985 • 181 citations

Topology and Structure of the C1q-Binding Site on C-Reactive Protein

2001 • 179 citations

The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms

1993 • 176 citations

Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter.

1990 • 176 citations

Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep 3B cells.

1991 • 173 citations

C-reactive protein binds to Fc gamma RI in transfected COS cells.

1995 • 163 citations

Interaction of C-Reactive Protein with Lymphocytes and Monocytes: Complement-Dependent Adherence and Phagocytosis

1976 • 162 citations

STUDIES OF ACUTE PHASE PROTEIN

1961 • 162 citations

Prevention of In vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein.

1997 • 160 citations

Serum Amyloid P Component and C-Reactive Protein Mediate Phagocytosis Through Murine FcγRs

2001 • 154 citations

Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia

1997 • 154 citations

Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.

1990 • 146 citations

Stimulating effect of C-reactive protein on phagocytosis of various species of pathogenic bacteria.

1971 • 141 citations

Inducible and tissue-specific expression of human C-reactive protein in transgenic mice.

1987 • 127 citations

C-reactive protein reacts with the U1 small nuclear ribonucleoprotein.

1989 • 125 citations

Interactions of C-reactive protein with the complement system. II. C-reactive protein-mediated consumption of complement by poly-L-lysine polymers and other polycations.

1975 • 125 citations

Testosterone and IL-6 Requirements for Human C-Reactive Protein Gene Expression in Transgenic Mice

1998 • 122 citations

STUDIES OF ACUTE-PHASE PROTEIN. II. LOCALIZATION OF Cx-REACTIVE PROTEIN IN HEART IN INDUCED MYOCARDIAL INFARCTION IN RABBITS*

1963 • 118 citations

Transactivation of C-Reactive Protein by IL-6 Requires Synergistic Interaction of CCAAT/Enhancer Binding Protein β (C/EBPβ) and Rel p50

2001 • 118 citations

ANTIGEN-BINDING MYELOMA PROTEINS IN MICE

1971 • 115 citations

Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae

1996 • 110 citations

C-reactive protein as a marker for cardiac ischemic events in the year after a first, uncomplicated myocardial infarction

1999 • 110 citations

Human C-Reactive Protein Is Protective against FatalSalmonella entericaSerovar Typhimurium Infection in Transgenic Mice

2000 • 108 citations

C-reactive protein increases production of IL-1α, IL-1β, and TNF-α, and expression of mRNA by human alveolar macrophages

1993 • 104 citations

Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli

1994 • 103 citations

Regulation of Human C-Reactive Protein Gene Expression by Two Synergistic IL-6 Responsive Elements

1996 • 101 citations

Analysis of the binding of C-reactive protein to histones and chromatin.

1988 • 101 citations

Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo

1997 • 94 citations

C-reactive Protein Inhibits Chemotactic Peptide-induced p38 Mitogen-activated Protein Kinase Activity and Human Neutrophil Movement

1999 • 88 citations

Complement-Dependent Acute-Phase Expression of C-Reactive Protein and Serum Amyloid P-Component

2000 • 88 citations

Phosphorylcholine decoration of lipopolysaccharide differentiates commensal Neisseriae from pathogenic strains: identification of licA‐type genes in commensal Neisseriae

2000 • 85 citations

Localization of C‐reactive protein in synovium of patients with rheumatoid arthritis

1977 • 85 citations

C-Reactive Protein Binding to Murine Leukocytes Requires Fcγ Receptors

2000 • 84 citations

Mediation of CRP-Dependent Phagocytosis through Mouse Macrophage Fc-Receptors

1977 • 84 citations

Opsonic properties of C-reactive protein. Stimulation by phorbol myristate acetate enables human neutrophils to phagocytize C-reactive protein-coated cells.

1985 • 83 citations

The association between C‐reactive protein on admission and mortality in patients with acute myocardial infarction

2000 • 83 citations

C-reactive protein inhibits pneumococcal activation of the alternative pathway by increasing the interaction between factor H and C3b.

1984 • 81 citations

Effect of Human C-Reactive Protein on Chemokine and Chemotactic Factor-Induced Neutrophil Chemotaxis and Signaling

1998 • 80 citations

C-reactive protein receptors on the human monocytic cell line U-937. Evidence for additional binding to Fc gamma RI.

1991 • 79 citations

Rabbits with elevated serum C-reactive protein exhibit diminished neutrophil infiltration and vascular permeability in C5a-induced alveolitis.

1993 • 79 citations

Human C-reactive protein inhibits neutrophil chemotaxis in vitro: possible implications for the adult respiratory distress syndrome.

1990 • 79 citations

Elucidation of a protease-sensitive site involved in the binding of calcium to C-reactive protein

1989 • 78 citations

The Rel Family Member P50 Mediates Cytokine-Induced C-Reactive Protein Expression by a Novel Mechanism

2000 • 76 citations

Probing the C1q-binding site on human C-reactive protein by site-directed mutagenesis.

1994 • 72 citations

Regulation of the human C-reactive protein gene, a major marker of inflammation and cancer.

1990 • 71 citations

cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression.

1990 • 70 citations

Binding of C-reactive protein to nucleated cells leads to complement activation without cytolysis.

1986 • 67 citations

Secretion of C-reactive protein becomes more efficient during the course of the acute phase response.

1985 • 66 citations

C‐REACTIVE PROTEIN BINDING SPECIFICITIES: ARTIFICIAL AND NATURAL PHOSPHOLIPID BILAYERS*

1982 • 63 citations

IN VITRO EFFECTS OF C-REACTIVE PROTEIN ON PHAGOCYTOSIS

1962 • 60 citations

A role for C-reactive protein in the complement-mediated stimulation of human neutrophils by type 27 Streptococcus pneumoniae.

1982 • 53 citations

Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopy.

1983 • 50 citations

Sublytic complement attack exposes C-reactive protein binding sites on cell membranes.

1994 • 50 citations

Binding of c‐reactive protein to human neutrophils. Inhibition of respiratory burst activity

1991 • 50 citations

Enhancement of Human Peripheral Blood Monocyte Respiratory Burst Activity by Aggregated C-Reactive Protein

1986 • 49 citations

Identification of a C-reactive Protein Binding Site in Two Hepatic Carboxylesterases Capable of Retaining C-reactive Protein within the Endoplasmic Reticulum

1996 • 48 citations

Inhibition of C5a des Arg-induced neutrophil alveolitis in transgenic mice expressing C-reactive protein

1994 • 47 citations

Two carboxylesterases bind C-reactive protein within the endoplasmic reticulum and regulate its secretion during the acute phase response.

1994 • 47 citations

Regulation of the Human C-reactive Protein Gene in Transgenic Mice

1995 • 46 citations

Probing the phosphocholine-binding site of human C-reactive protein by site-directed mutagenesis.

1992 • 42 citations

Activation of human monocyte tumoricidal activity by C-reactive protein.

1987 • 39 citations

Internalization and degradation of receptor bound C-reactive protein by U-937 cells: induction of H2O2 production and tumoricidal activity

1991 • 35 citations

Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67.

1997 • 33 citations

Complement-induced solubilization of C-reactive protein-pneumococcal C-polysaccharide precipitates: evidence for covalent binding of complement proteins to C-reactive protein and to pneumococcal C-polysaccharide.

1982 • 26 citations

Assembly of complement components C5b-8 and C5b-9 on lipid bilayer membranes: visualization by freeze-etch electron microscopy

1989 • 17 citations

Binding of human C4 to C-reactive protein-pneumococcal C-polysaccharide complexes during activation of the classical complement pathway

1983 • 16 citations

C‐reactive protein decreases protein phosphorylation in stimulated human neutrophils

1988 • 14 citations

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