Vaccination with heat shock protein–peptide complexes: from basic science to clinical applications

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Roles of heat-shock proteins in innate and adaptive immunity

2002 • 1,037 citations

Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

2002 • 845 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.

1960 • 736 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 • 528 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Mast Cell-Derived Exosomes Induce Phenotypic and Functional Maturation of Dendritic Cells and Elicit Specific Immune Responses In Vivo

2003 • 413 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

Vaccination of Metastatic Melanoma Patients With Autologous Tumor-Derived Heat Shock Protein gp96-Peptide Complexes: Clinical and Immunologic Findings

2002 • 387 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

1994 • 363 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

1986 • 295 citations

Primary Tumor Tissue Lysates Are Enriched in Heat Shock Proteins and Induce the Maturation of Human Dendritic Cells

2001 • 260 citations

Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs

2002 • 258 citations

Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells

2002 • 255 citations

Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: A pilot study

2000 • 250 citations

Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer.

2003 • 242 citations

Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo

2000 • 223 citations

Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24.

1996 • 205 citations

The Receptor for Heat Shock Protein 60 on Macrophages Is Saturable, Specific, and Distinct from Receptors for Other Heat Shock Proteins

2002 • 198 citations

Immunization with a Lymphocytic Choriomeningitis Virus Peptide Mixed with Heat Shock Protein 70 Results in Protective Antiviral Immunity and Specific Cytotoxic T Lymphocytes

1998 • 193 citations

Heat shock proteins generate β-chemokines which function as innate adjuvants enhancing adaptive immunity

2000 • 189 citations

Stress-Induced Proteins in Immune Response to Cancer

1991 • 179 citations

Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprisingMycobacterium bovisbacille Calmette–Guérin (BCG) hsp65 and HPV16 E7

2000 • 176 citations

Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells.

2001 • 173 citations

Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity

2001 • 165 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer

2000 • 143 citations

Immunotherapy of human cancer: lessons from mice

2000 • 143 citations

Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96

1998 • 130 citations

GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression

2002 • 107 citations

The serologically unique cell surface antigen of zajdela ascitic hepatoma is also its tumor‐associated transplantation antigen

1984 • 102 citations

Activity of HspE7, a Novel Immunotherapy, in Patients with Anogenital Warts

2002 • 99 citations

Development of a recombinant HSP110-HER-2/neu vaccine using the chaperoning properties of HSP110.

2002 • 93 citations

Cutting Edge: CD91-Independent Cross-Presentation of GRP94(gp96)-Associated Peptides

2002 • 92 citations

Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70

2001 • 91 citations

Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides

1997 • 89 citations

gp96—The immune system's Swiss army knife

2000 • 89 citations

Human platelets express heat shock protein receptors and regulate dendritic cell maturation

2002 • 81 citations

Expression of a shared tumor-specific antigen by two chemically induced BALB/c sarcomas.

1987 • 79 citations

5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors.

1987 • 68 citations

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2000 • 67 citations

Phylogenetic conservation of the molecular and immunological properties of the chaperones gp96 and hsp70

2001 • 65 citations

gp96-Peptide Vaccination of Mice against Intracellular Bacteria

2001 • 64 citations

Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.

1999 • 64 citations

Generation of Tumor-Specific Cytotoxic T Lymphocytes and Memory T Cells by Immunization with Tumor-Derived Heat Shock Protein gp96

1998 • 62 citations

Immunotherapy using heat-shock protein preparations of leukemia cells after syngeneic bone marrow transplantation in mice

2001 • 62 citations

Do human cancers express sharedprotectiveantigens? or The necessity of remembrance of things past

1996 • 61 citations

Heat shock protein-peptide complexes elicit cytotoxic T-lymphocyte and antibody responses specific for bovine herpesvirus 1

2001 • 60 citations

Tumor-derived multiple chaperone enrichment by free-solution isoelectric focusing yields potent antitumor vaccines

2000 • 59 citations

Priming of CD8+ CTL effector cells in mice by immunization with a stress protein–influenza virus nucleoprotein fusion molecule

1999 • 50 citations

Immunization with Chaperone-Peptide Complex Induces Low-Avidity Cytotoxic T Lymphocytes Providing Transient Protection against Herpes Simplex Virus Infection

2002 • 41 citations

Determinants of efficacy of immunotherapy with tumor-derived heat shock protein gp96.

2001 • 36 citations

Quality of life in patients with metastatic renal cell carcinoma participating in a phase I trial of an autologous tumor-derived vaccine

2002 • 34 citations

Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses

2002 • 32 citations

Peripheral Blood Mononuclear Cell Proliferation to Heat Shock Protein–70 Derived from Autologous Lung Carcinoma

2002 • 9 citations