Development of a recombinant HSP110-HER-2/neu vaccine using the chaperoning properties of HSP110.

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Heat shock proteins.

1990 • 1,365 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

1996 • 992 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

1994 • 363 citations

Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.

2000 • 354 citations

Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine.

1999 • 339 citations

The Hsp110 and Grp170 stress proteins: newly recognized relatives of the Hsp70s

2000 • 317 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

1986 • 295 citations

Calreticulin, a Peptide-binding Chaperone of the Endoplasmic Reticulum, Elicits Tumor- and Peptide-specific Immunity

1999 • 252 citations

Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: A pilot study

2000 • 250 citations

Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo

2000 • 223 citations

hsp110 Protects Heat-denatured Proteins and Confers Cellular Thermoresistance

1997 • 217 citations

HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer

1997 • 173 citations

Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum: Role in Immune Response to Cancer and in Antigen Presentation

1993 • 167 citations

Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity

2001 • 165 citations

The Chaperoning Activity of hsp110

1999 • 150 citations

Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells.

1997 • 146 citations

Heat shock proteins: the fountainhead of innate and adaptive immune responses

2000 • 134 citations

Early and multifocal tumors in breast, salivary, Harderian and epididymal tissues developed in MMTY-Neu transgenic mice

1992 • 123 citations

Mycobacterial heat‐shock proteins as carrier molecules

1991 • 122 citations

Single-molecule observation of protein–protein interactions in the chaperonin system

2001 • 118 citations

Mycobacterial heat‐shock proteins as carrier molecules. II: The use of the 70‐kDa mycobacterial heat‐shock protein as carrier for conjugated vaccinescan circumvent the need for adjuvants and Bacillus Calmette Guérin priming)

1992 • 114 citations

In Vivo and In Vitro Activation of T Cells After Administration of Ag-Negative Heat Shock Proteins

1999 • 99 citations

Heat shock protein–peptide complexes as immunotherapy for human cancer

1998 • 84 citations

Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.

2000 • 68 citations

Class I MHC presentation of exogenous antigens

1996 • 65 citations

Contribution of molecular chaperones to protein folding in the cytoplasm of prokaryotic and eukaryotic cells

2001 • 42 citations

Stress protein/peptide complexes derived from autologous tumor tissue as tumor vaccines

1999 • 39 citations

Specificity of the IgG Response in Mice and Human Breast Cancer Patients Following Immunization Against Synthetic Sialyl-Tn, An Epitope with Possible Functional Significance in Metastasis

1994 • 36 citations

Biophysical Analysis of the Endoplasmic Reticulum-Resident Chaperone/Heat Shock Protein gp96/GRP94 and Its Complex with Peptide Antigen

2001 • 32 citations

The ability of heat‐killed Mycobacterium vaccae to stimulate a cytotoxic T‐cell response to an unrelated protein is associated with a 65 kilodalton heat‐shock protein

2001 • 31 citations