Role of the dopaminergic system in depression

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

The validity of animal models of depression

1984 • 1,365 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT

1969 • 705 citations

The neuropharmacological basis of reward

1991 • 457 citations

Depression in Parkinson's disease: a quantitative and qualitative analysis.

1986 • 393 citations

Specificity of the learned helplessness model of depression

1982 • 383 citations

Dopamine and depression

1993 • 349 citations

Animal models as simulations of depression

1991 • 328 citations

Differential Response to Chlorpromazine, Imipramine, and Placebo

1970 • 302 citations

Dopamine receptor subtypes: beyond the D1/D2 classification

1990 • 295 citations

Effect of inescapable shock on subsequent escape performance: Catecholaminergic and cholinergic mediation of response initiation and maintenance

1979 • 277 citations

Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain

1979 • 276 citations

Current Developments in Psychopharmacology

1981 • 275 citations

Psychomotor Activity and Cerebrospinal Fluid Amine Metabolites in Affective Illness

1973 • 263 citations

Cerebrospinal Fluid Amine Metabolites in Affective Illness: The Probenecid Technique

1973 • 245 citations

Current Developments in Psychopharmacology

1978 • 242 citations

ehavioural evidence for supersensitivtiy of postsynaptic dopamine receptors in the mesolimbic system after chronic administration of desipramine

1981 • 239 citations

Anti-depressive treatment in Parkinson's disease A CONTROLLED TRIAL OF THE EFFECT OF NORTRIPTYLINE IN PATIENTS WITH PARKINSON'S DISEASE TREATED WITH L-DOPA

2009 • 217 citations

Deficits of escape performance following catecholamine depletion: Implications for behavioral deficits induced by uncontrollable stress

1979 • 196 citations

Homovanillic and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid of Depressed Patients

1971 • 177 citations

A Controlled Study of the Antidepressant Efficacy and Side Effects of ( — )-Deprenyl

1989 • 175 citations

Effects of a Dopamine Agonist Piribedil in Depressed Patients

1978 • 169 citations

Deprenyl (selegiline): the history of its development and pharmacological action

1983 • 159 citations

Electroconvulsive Shock: Progressive Dopamine Autoreceptor Subsensitivity Independent of Repeated Treatment

1980 • 155 citations

Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine

1977 • 155 citations

A double-blind evaluation of electroconvulsive therapy in Parkinson's disease with “on-off” phenomena

1987 • 153 citations

In vivoevaluation of striatal dopamine reuptake sites using 11C-nomifensine and positron emission tomography

1987 • 146 citations

Dopamine and depression: A review of recent evidence. III. The effects of antidepressant treatments

1983 • 144 citations

Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders

1975 • 140 citations

Brain noradrenaline depletion prevents ECS-induced enhancement of serotonin-and dopamine-mediated behaviour

1980 • 139 citations

Retarded depression and the dopamine metabolism

1971 • 138 citations

Acute effects of bupropion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis

1989 • 134 citations

ECT and Parkinson's disease revisited: a "naturalistic" study

1989 • 126 citations

Studies of bupropion's mechanism of antidepressant activity.

1983 • 125 citations

Dopaminergic mechanism of imipramine action in an animal model of depression

1990 • 122 citations

Major tranquillisers used as antidepressants

1982 • 120 citations

Studies on possible mechanisms of action of electroconvulsive therapy; effects of repeated electrically induced seizures on rat brain receptors for monoamines and other neurotransmitters

1981 • 117 citations

Dopamine and depression: A review of recent evidence. II. Theoretical approaches

1983 • 111 citations

The endogenous—neurotic distinction as a predictor of response to antidepressant drugs

1976 • 106 citations

Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders

1978 • 100 citations

L-Deprenil, A Selective Monoamine Oxidase Type B Inhibitor, in the Treatment of Depression: A Double Blind Evaluation

1983 • 94 citations

Is the failure of (-)deprenyl, a selective monoamine oxidase B inhibitor, to alleviate depression related to freedom from the cheese effect?

1981 • 90 citations

Bromocriptine and imipramine in endogenous depression

1981 • 88 citations

Dopaminergic hypothesis for retarded depression: a symptom profile for predicting therapeutical responses

1991 • 88 citations

Characterisation of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis

1991 • 87 citations

Bupropion in Depression

1988 • 81 citations

Repeated electroconvulsive shock prevents the sedative effect of small doses of apomorphine

1981 • 77 citations

Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.

1977 • 74 citations

Antidepressant Profile of Bupropion and three Metabolites in Mice

1990 • 72 citations

Neuroendocrine evidence for increased responsiveness of dopamine receptors in humans following electroconvulsive therapy

1982 • 71 citations

The Neuropharmacological Basis of Reward

1991 • 71 citations

Blood—brain barrier permeability during electroshock seizures in the rat

1977 • 70 citations

Heterogeneity of amphetamine response in depressed patients

1981 • 70 citations

Increased sensitivity to dopaminergic agonists after repeated electroconvulsive shock (ECS) in rats

1981 • 66 citations

Effect of ECT on the Neuroendocrine Response to Apomorphine in Severely Depressed Patients

1982 • 62 citations

6‐[¹⁸F]Fluoro‐L‐DOPA probes dopamine turnover rates in central dopaminergic structures

1990 • 61 citations

Neurotransmitter precursors for the treatment of depression.

1982 • 61 citations

A randomized double blind group comparative study of sulpiride and amitriptyline in affective disorder

1983 • 61 citations

4‐[¹⁸F]Fluoro‐L‐m‐Tyrosine: An L‐3,4‐Dihydroxyphenylalanine Analog for Probing Presynaptic Dopaminergic Function with Positron Emission Tomography

1989 • 60 citations

Repeated electroconvulsive shock increases the behavioural responses of rats to injection of both dopamine and dibutyryl cyclic amp into the nucleus accumbens

1978 • 55 citations

ELECTROCONVULSIVE THERAPY AND THE BRAIN: EVIDENCE FOR INCREASED DOPAMINE-MEDIATED RESPONSES

1982 • 54 citations

Positron emission tomography (PET) studies of dopaminergic/cholinergic interaction in the baboon brain

1990 • 53 citations

Behavioural evidence of dopamine receptor stimulation by piribedil (ET495) and its metabolite S584

1974 • 49 citations

Review of placebo-controlled trials with bupropion.

1983 • 48 citations

Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo

1989 • 46 citations

Enhanced 5-hydroxytryptamine and dopamine-mediated behavioural responses following convulsions—III the effects of monoamine antagonists and synthesis inhibitors on the ability of electroconvulsive shock to enhance responses

1980 • 44 citations

Electroconvulsive shock produces large increases in interstitial concentrations of dopamine in the rat striatum: an in vivo microdialysis study.

1991 • 44 citations

Interesting times for dopamine receptors

1991 • 43 citations

Pharmacological and biochemical evidence for the dopamine agonistic effect of bromocriptine.

1978 • 43 citations

The Relative Efficacy of l-Deprenyl, a Selective Monoamine Oxidase Type B Inhibitor, in Endogenous and Nonendogenous Depression

1982 • 40 citations

Nomifensine maleate: a new second-generation antidepressant.

1985 • 38 citations

Depression with the Use of Alpha-Methyldopa

1967 • 35 citations

PET imaging of dopamine receptors in human basal ganglia: relevance to mental illness

1990 • 35 citations

EFFECTS OF LOW DOSES OF A DOPAMINE-RECEPTOR STIMULATOR IN MANIA

1976 • 35 citations

Hallucinations in patients with major depression

1985 • 35 citations

Clinical evaluation and natural course of depression.

1983 • 35 citations

A Mechanism for the Efficacy of ECT in Parkinson's Disease.

1988 • 32 citations

Localized alterations of dopamine receptor binding in rat brain by repeated electroconvulsive shock: an autoradiographic study

1990 • 31 citations

Lack of Effect of Repeated Electroconvulsive Shock on [³H]Spiroperidol and [³H]5‐Hydroxytryptamine Binding and Cholinergic Parameters in Rat Brain

1980 • 30 citations

Non-steady-state measurement of in vivo radioligand binding with positron emission tomography: specificity analysis and comparison with in vitro binding

1991 • 29 citations

Interactions of amineptine with the neuronal dopamine uptake system: Neurochemicalin vitro andin vivo studies

1987 • 29 citations

BROMOCRIPTINE AS ANTIDEPRESSANT: DOUBLE-BLIND COMPARATIVE STUDY WITH IMIPRAMINE IN PSYCHOGENIC AND ENDOGENOUS DEPRESSION

1981 • 28 citations

6. Psychosomatic Aspects of Movement Disorders

2015 • 28 citations

Effect of long term amineptine treatment on pre‐ and postsynaptic mechanisms in rat brain

1986 • 26 citations

Dopamine and Depression

2000 • 26 citations

Do antidepressants induce dopamine autoreceptor subsensitivity?

1982 • 25 citations

Further aspects of nomifensine pharmacology.

1977 • 25 citations

Chronic antidepressant administration fails to attenuate apomorphine-induced decreases in rat striatal dopamine metabolites

1984 • 24 citations

Dopaminergic agonist nomifensine compared with amitriptyline: a double‐ blind clinical trial in acute primary depressions.

1977 • 18 citations

Controlled randomized group comparison of nomifensine and imipramine in depressive illness.

1977 • 17 citations

Repeated ECS enhances dopamine D-1 but not D-2 agonist-induced behavioural responses in rats

1990 • 17 citations

Behavioral Differentiation between Effects elicited at Dopamine D-1 and D-2 Receptors in Rats with Normosensitive DA Receptors

1988 • 16 citations

[Polygraphic, clinical and therapeutic markers of dopamine-dependent depressions].

1987 • 16 citations

Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.

1974 • 15 citations

Repeated treatment with imipramine decreased the number of [3H]piflutixol binding sites in the rat striatum

1985 • 13 citations

A clinical comparison of nomifensine and amitriptyline.

1977 • 13 citations

Cerebrospinal fluid amine metabolites in affective illness

1974 • 12 citations

Effects of chronic electroconvulsive shock on D1 and D2 dopamine receptor-mediated activity of adenylate cyclase in homogenates of striatum and limbic forebrain of rat

1989 • 12 citations

On the mechanism of potentiation of apomorphine-induced stereotypy due to electroconvulsive shock

1987 • 12 citations

Rauwolfia and biological psychiatry

1982 • 11 citations

DOPAMINE RECEPTORS: CLASSIFICATION, PROPERTIES AND DRUG DEVELOPMENT

1989 • 11 citations

Evaluation of the Efficacy of Amineptine in a Population of 1,229 Depressed Patients: Results of a Multicenter Study Carried Out by 135 General Practitioners

1989 • 10 citations

[L-tyrosine cures, immediate and long term, dopamine-dependent depressions. Clinical and polygraphic studies].

1988 • 10 citations

Bromocriptine in Treatment of Depression

1989 • 7 citations

A Double-Blind Comparative Study: Amineptine (Survector 100) Versus Imipramine

1989 • 6 citations

Noradrenergic and dopaminergic effects of nomifensine in healthy volunteers

1987 • 6 citations

Models of depressive disorders : psychological, biological, and genetic perspectives

1989 • 5 citations

A Multicenter Italian Study of Amineptine (Survector 100)

1989 • 3 citations

Deleted Work

1955 • 0 citations