Sphingosine: a mediator of acute renal tubular injury and subsequent cytoresistance.

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney

1994 • 832 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

The cell biology of ischemic renal injury

1991 • 343 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.

1995 • 197 citations

A possible role of sphingosine in induction of apoptosis by tumor necrosis factor‐α, in human neutrophils

1994 • 168 citations

Acute renal failure in the setting of bone marrow transplatation

1994 • 167 citations

Lipid alterations induced by renal ischemia: Pathogenic factor in membrane damage

1984 • 140 citations

Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling.

1993 • 137 citations

Responses of the ischemic acute renal failure kidney to additional ischemic events

1984 • 116 citations

Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells

1992 • 106 citations

Acquired resistance to acute renal failure

1987 • 95 citations

Inhibition of glycoprotein traffic through the secretory pathway by ceramide.

1993 • 94 citations

An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury.

1994 • 75 citations

Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.

1991 • 69 citations

Protein synthesis inhibition induces cytoresistance in cultured human proximal tubular (HK-2) cells

1995 • 44 citations

The role of free fatty acids in hypoxia-induced injury to renal proximal tubule cells

1989 • 40 citations

Amino acid protection of cultured kidney tubule cells against calcium ionophore-induced lethal cell injury.

1991 • 40 citations

Obstruction of proximal tubules initiates cytoresistance against hypoxic damage

1995 • 39 citations

Brefeldin A promotes hydrolysis of sphingomyelin.

1992 • 36 citations

Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules

1992 • 36 citations

Heme protein-induced tubular cytoresistance: Expression at the plasma membrane level

1995 • 35 citations

Importance of adenosine triphosphate in phospholipase A2-induced rabbit renal proximal tubule cell injury.

1988 • 32 citations

Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion.

1989 • 28 citations

Sphingosine‐1‐phosphate inhibits extracellular matrix protein‐induced haptotactic motility but not adhesion of B16 mouse melanoma cells

1994 • 28 citations