Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Mechanism of multidrug resistance

1988 • 630 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Quantitation of free sphingosine in liver by high-performance liquid chromatography

1988 • 315 citations

[31] Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain

1983 • 281 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

1990 • 200 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Action of calcium antagonists on multidrug resistant cells

1987 • 144 citations

Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay

1989 • 133 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

1990 • 116 citations

Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines

1986 • 91 citations

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1989 • 86 citations

Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells.

1989 • 85 citations

Resistance to Antineoplastic Drugs

1990 • 81 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate.

1984 • 79 citations

Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells

1990 • 78 citations

Verapamil-mediated sensitization of doxorubicin-selected pleiotropic resistance in human sarcoma cells: selectivity for drugs which produce DNA scission.

1986 • 73 citations

Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines.

1990 • 63 citations

Reduction of Acid Sphingomyelinase Activity in Human Fibroblasts Induced by AY-9944 and Other Cationic Amphiphific Drugs1

1985 • 59 citations

Mechanisms regulating cell resistance to adriamycin evidence that drug accumulation in resistant cells is modulated by phosphorylation of a plasma membrane glycoprotein

1985 • 59 citations

Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.

1989 • 56 citations

Two pyridine analogues with more effective ability to reverse multidrug resistance and with lower calcium channel blocking activity than their dihydropyridine counterparts.

1990 • 49 citations

Activities of newly synthesized dihydropyridines in overcoming of vincristine resistance, calcium antagonism, and inhibition of photoaffinity labeling of P-glycoprotein in rodents.

1990 • 45 citations

Glutathione S-transferases and glutathione peroxidases in doxorubicin-resistant murine leukemic P388 cells

1989 • 43 citations

An inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine(H-7) inhibits TPA-induced reduction of vincristine uptake from P388 murine leukemic cell

1986 • 43 citations

Evidence of DNA topoisomerase II-dependent mechanisms of multidrug resistance in P388 leukemia cells.

1990 • 43 citations

SR33557, an indolizinsulfone blocker of Ca2+ channels: identification of receptor sites and analysis of its mode of action.

1989 • 36 citations

Growth‐dependent subcellular redistribution of protein kinase C in cultured porcine aortic endothelial cells

1988 • 31 citations

Synthesis of pyrenesulfonylamido-sphingomyelin and its use as substrate for determining sphingomyelinase activity and diagnosing Niemann-Pick disease

1988 • 29 citations

Lipid and lysosomal enzymes in human fibroblasts cultured with perhexiline maleate

1981 • 22 citations

Mechanisms of the in vivo resistance to adriamycin and modulation by calcium channel blockers in mice.

1989 • 20 citations