Molecular Analysis of TGFβ Signal Transduction

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes.

1990 • 377 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen

1992 • 315 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

1992 • 272 citations

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

1993 • 261 citations

Growth Factors Proto-Oncogenes and Plasticity of the Cardiac Phenotype

1991 • 228 citations

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

1991 • 173 citations

Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1

1994 • 167 citations

Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor‐β type II receptor family

1993 • 164 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily

1994 • 131 citations

Cardiac myocytes as targets for the action of peptide growth factors.

1990 • 126 citations

Induction of cardiac muscle differentiation in isolated animal pole explants of Xenopus laevis embryos

1993 • 96 citations

Tetracycline-regulated cardiac gene expression in vivo.

1994 • 90 citations

The murine type II TGF-β receptor has a coincident embryonic expression and binding preference for TGF-β1

1994 • 87 citations

Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A

1991 • 83 citations

Transforming growth factor-beta in cardiac ontogeny and adaptation.

1993 • 82 citations

p21 Ras as a governor of global gene expression.

1994 • 80 citations

Transforming growth factor‐β in the early mouse embryo: Implications for the regulation of muscle formation and implantation

1993 • 78 citations

Well-defined growth factors promote cardiac development in axolotl mesodermal explants

1991 • 65 citations

Cardiac growth factors

1991 • 64 citations

Fluorescence-guided laser-assisted balloon angioplasty in patients with femoropopliteal occlusions.

1990 • 55 citations

Cardioprotective actions of transforming growth factor-β

1993 • 19 citations

The inducer that never was

1994 • 3 citations