Take care of your chromosomes lest cancer take care of you

Genetic instabilities in human cancers

1998 • 4,165 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Connecting Chromosomes, Crisis, and Cancer

2002 • 564 citations

Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations

2002 • 416 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

DNA double strand break repair and chromosomal translocation: Lessons from animal models

2001 • 323 citations

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

2001 • 289 citations

Chromosome translocations: dangerous liaisons revisited

2001 • 272 citations

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

2002 • 229 citations

Debate Surges Over the Origins of Genomic Defects in Cancer

2002 • 154 citations

Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome

1998 • 116 citations

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

1999 • 96 citations

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice

2003 • 81 citations

Animal Models of Tumor-Suppressor Genes

2001 • 56 citations