Nitric oxide signalling in the nervous system

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

Histochemical mapping of nitric oxide synthase in the rat brain

1992 • 1,858 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

1991 • 1,016 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

Nitric oxide (NO) and nociceptive processing in the spinal cord

1993 • 958 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

1990 • 653 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1992 • 484 citations

<scp>l</scp>‐N^G‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse

1991 • 481 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

1990 • 456 citations

Nitric oxide-induced blockade of NMDA receptors

1992 • 455 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

1992 • 378 citations

Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain.

1993 • 339 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathway

1991 • 301 citations

The transport of cationic amino acids across the plasma membrane of mammalian cells

1985 • 287 citations

Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain.

1981 • 279 citations

Nitric oxide induces neurotransmitter release from hippocampal slices

1992 • 274 citations

A central nervous system action of nitric oxide in blood pressure regulation.

1992 • 269 citations

Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?

1992 • 260 citations

Effect of Nitroprusside (Nitric Oxide) on Endogenous Dopamine Release from Rat Striatal Slices

1992 • 253 citations

Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

1992 • 239 citations

Nitric oxide controls oscillatory activity in thalamocortical neurons

1992 • 227 citations

Excitatory Amino Acid Receptors Coupled to the Nitric Oxide/Cyclic GMP Pathway in Rat Cerebellum During Development

1991 • 224 citations

Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

1993 • 223 citations

Comparative effects of some nitric oxide donors on cyclic GMP levels in rat cerebellar slices

1991 • 207 citations

Cellular Origins of Cyclic GMP Responses to Excitatory Amino Acid Receptor Agonists in Rat Cerebellum In Vitro

1987 • 196 citations

Evidence for an Astrocyte‐Derived Vasorelaxing Factor with Properties Similar to Nitric Oxide

1990 • 196 citations

NG-Nitro-L-arginine prevents morphine tolerance

1992 • 183 citations

Nitric oxide releases acetylcholine in the basal forebrain

1992 • 183 citations

Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat

1991 • 172 citations

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell <scp>l</scp>‐arginine transporter

1992 • 172 citations

Cellular uptake disguises action of L‐glutamate on N‐methyl‐D‐aspartate receptors: With an appendix: Diffusion of transported amino acids into brain slices

1985 • 171 citations

Immunocytochemistry of cGMP in the Cerebellum of the Immature, Adult, and Aged Rat: the Involvement of Nitric Oxide. A Micropharmacological Study

1990 • 159 citations

Sources and targets of nitric oxide in rat cerebellum

1992 • 155 citations

Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons

1992 • 152 citations

Regulation of Neuronal Nitric Oxide and Cyclic GMP Formation by Ca²⁺

1992 • 151 citations

Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion.

1992 • 149 citations

Nitric oxide synthase and GABA colocalize in lamina II of rat spinal cord

1992 • 149 citations

Inhibition of Nitric Oxide Synthase Blocks N‐Methyl‐D‐Aspartate‐, Quisqualate‐, Kainate‐, Harmaline‐, and Pentylenetetrazole‐Dependent Increases in Cerebellar Cyclic GMP In Vivo

1990 • 148 citations

Nitric oxide may act as a messenger between dorsal root ganglion neurones and their satellite cells

1992 • 136 citations

Effects of NG‐nitro‐L‐arginine and L‐arginine on regional cerebral blood flow in the cat.

1992 • 126 citations

Predominant localization in glial cells of freel-arginine. Immunocytochemical evidence

1991 • 119 citations

Unilateral hindpaw inflammation produces a bilateral increase in NADPH-diaphorase histochemical staining in the rat lumbar spinal cord

1992 • 110 citations

Immunohistochemical localization of argininosuccinate synthetase in the rat brain in relation to nitric oxide synthase-containing neurons

1992 • 104 citations

Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats

1992 • 102 citations

Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation.

1992 • 100 citations

Retinal on-bipolar cells contain a nitric oxide-sensitive guanylate cyclase

1992 • 99 citations

Regulation by Nitroxidergic Nerve of Arterial Tone

1992 • 96 citations

Immunocytochemical localization of argininosuccinate synthetase in the rat brain

1991 • 93 citations

Citrulline in the rat brain: Immunohistochemistry and coexistence with NADPH-diaphorase

1991 • 92 citations

Cyclic GMP and cell death in rat cerebellar slices

1988 • 92 citations

Differential cellular localization of enzymes ofl-arginine metabolism in the rat brain

1990 • 90 citations

A Nitric Oxide Synthase Activity Selectively Stimulated by NMDA Receptors Depends on Protein Kinase C Activation in Mouse Striatal Neurons

1992 • 87 citations

Activated astrocytes of the mouse hippocampus contain high levels of NADPH-diaphorase

1992 • 83 citations

Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia

1991 • 82 citations

Involvement of the nitric oxide-cyclic GMP pathway in the desensitization of bradykinin responses of cultured rat sensory neurons

1992 • 80 citations

Cyclic GMP depresses hippocampal Ca2+ current through a mechanism independent of cGMP-dependent protein kinase

1988 • 80 citations

Cyclic Nucleotides in the Nervous System

1984 • 76 citations

Nitric oxide mediates Fos expression in the spinal cord induced by mechanical noxious stimulation

1992 • 75 citations

Climbing Fibres as a Source of Nitric Oxide in the Cerebellum

1991 • 72 citations

Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus

1992 • 63 citations

Glutathione: New candidate neuropeptide in the central nervous system

1992 • 63 citations

Endothelin and a Ca²⁺ ionophore raise cyclic GMP levels in a neuronal cell line via formation of nitric oxide

1990 • 55 citations

Delayed increase of extracellular arginine, the nitric oxide precursor, following electrical white matter stimulation in rat cerebellar slices

1992 • 55 citations

Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices.

1991 • 52 citations

Characterization of noradrenaline-stimulated cyclic GMP formation in brain astrocytes in culture

1992 • 45 citations

Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside

1991 • 43 citations

Mechanism of stimulation of cyclic‐GMP level in a neuronal cell line mediated by serotonin (5‐HT₃) receptors

1990 • 40 citations

Deleted Work

1955 • 0 citations