Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, Is an Endocytic Receptor that Induces the Formation of Birbeck Granules

2000 • 934 citations

The Rab5 effector EEA1 is a core component of endosome docking

1999 • 850 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England.

1961 • 812 citations

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

1992 • 741 citations

Ia antigen expression on human epidermal Langerhans cells

1977 • 603 citations

Reactivity of Langerhans cells with hybridoma antibody.

1981 • 560 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

Epidermal Langerhans cells express Ia antigens

1977 • 493 citations

Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes

1998 • 479 citations

ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes.

1992 • 464 citations

A Regulatory Role for ARF6 in Receptor-Mediated Endocytosis

1995 • 451 citations

Direct Pathway from Early/Recycling Endosomes to the Golgi Apparatus Revealed through the Study of Shiga Toxin B-fragment Transport

1998 • 425 citations

Rab11 Regulates the Compartmentalization of Early Endosomes Required for Efficient Transport from Early Endosomes to the Trans-Golgi Network

2000 • 402 citations

The Actin Cytoskeleton Is Required for Receptor-mediated Endocytosis in Mammalian Cells

1997 • 394 citations

Brefeldin A

1999 • 385 citations

Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes

1991 • 378 citations

A novel class of clathrin-coated vesicles budding from endosomes.

1996 • 369 citations

Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of brefeldin A and G protein activators

1992 • 358 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Cholesterol-dependent retention of GPI-anchored proteins in endosomes

1998 • 313 citations

The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface

1999 • 282 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

The small GTP-binding protein rab6 functions in intra-Golgi transport.

1994 • 251 citations

In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella.

1994 • 250 citations

An Endocytosed TGN38 Chimeric Protein Is Delivered to the TGN after Trafficking through the Endocytic Recycling Compartment in CHO Cells

1998 • 242 citations

Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways

1999 • 211 citations

Tubular early endosomal networks in AtT20 and other cells.

1991 • 208 citations

Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.

1993 • 205 citations

Retrograde Transport of KDEL-bearing B-fragment of Shiga Toxin

1997 • 200 citations

Actin filaments facilitate two steps of endocytosis

1996 • 187 citations

The langerhans cell.

1972 • 167 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

A Monoclonal Antibody Specifically Reactive to Human Langerhans Cells

1986 • 158 citations

Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.

1995 • 153 citations

Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation.

1989 • 140 citations

THE FINE STRUCTURE OF THE LANGERHANS CELL GRANULE

1967 • 139 citations

Mannose 6-Phosphate Receptors and ADP-ribosylation Factors Cooperate for High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes

1996 • 121 citations

Langerhans' Cell Granules in Histiocytosis X

1967 • 113 citations

Human Epidermal Langerhans Cells Internalize by Receptor-Mediated Endocytosis T6 (CD1 “NA1/34”) Surface Antigen. Birbeck Granules Are Involved in the Intracellular Traffic of the T6 Antigen

1987 • 97 citations

Langerhans' Cell Granule

1971 • 86 citations

A Di-Leucine Sequence and a Cluster of Acidic Amino Acids Are Required for Dynamic Retention in the Endosomal Recycling Compartment of Fibroblasts

2001 • 79 citations

Biogenesis of synaptic vesicles in vitro.

1995 • 67 citations

Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells

1998 • 64 citations

A monoclonal antibody to the heavy chain of clathrin.

1983 • 62 citations

Expression of Major Histocompatibility Complex Class II Molecules in HeLa Cells Promotes the Recruitment of AP-1 Golgi-specific Assembly Proteins on Golgi Membranes

1996 • 62 citations

CD1a Molecules Traffic Through the Early Recycling Endosomal Pathway in Human Langerhans Cells11Presented in part at the 6th International Workshop on Langerhans Cells, New York, NY, U.S.A., 8–10 October 1999 (J Invest Dermatol 114:228 2000).

2001 • 61 citations

Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules

1999 • 61 citations

The Langerhans Cell Granule Is an Adsorptive Endocytic Organelle

1985 • 54 citations

Identification of an Insulin-responsive, Slow Endocytic Recycling Mechanism in Chinese Hamster Ovary Cells

1998 • 48 citations

Alpha IIb beta 3 integrin dissociation induced by EDTA results in morphological changes of the platelet surface-connected canalicular system with differential location of the two separate subunits.

1993 • 46 citations

Derivation of Langerhans Cell Granules from Cytomembrane

1985 • 46 citations

Cytomembrane-Derived Birbeck Granules Transport Horseradish Peroxidase to the Endosomal Compartment in the Human Langerhans Cells

1992 • 46 citations

Granule Formation in the Langerhans Cell**From the Division of Dermatology, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455.

1966 • 43 citations

HLA class II expression on human epidermal langerhans cells in situ: Upregulation during the elicitation of allergic contact dermatitis

1992 • 41 citations

Appearance of Birbeck Granule-like Structures in Anti-T6 Antibody-Treated Human Epidermal Langerhans Cells

1988 • 37 citations

Current Problems in Dermatology

1971 • 35 citations

ATPase and morphologic changes in Langerhans cells induced by epicutaneous application of a sensitizing dose of DNFB

1989 • 31 citations

Sequential Production of Birbeck Granules Through Adsorptive Pinocytosis

1984 • 30 citations

Langerhans' cells and macrophages in eosinophilic granuloma

1984 • 26 citations

Ultrastructural Similarities Between Epidermal Langerhans Cell Birbeck Granules and the Surface-Connected Canalicular System of EDTA-Treated Human Blood Platelets

1991 • 18 citations