Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45

Innate Immune Recognition

2002 • 8,157 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

The many faces of macrophage activation

2003 • 1,860 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

2003 • 1,593 citations

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 • 1,296 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

CD45: A Critical Regulator of Signaling Thresholds in Immune Cells

2003 • 849 citations

C-type lectin receptors on dendritic cells and langerhans cells

2002 • 824 citations

The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells

2002 • 613 citations

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

2001 • 555 citations

Jurkat T cells and development of the T-cell receptor signalling paradigm

2004 • 540 citations

Self- and Nonself-Recognition by C-Type Lectins on Dendritic Cells

2004 • 500 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Glucocorticoids Affect Human Dendritic Cell Differentiation and Maturation

1999 • 473 citations

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase

2002 • 452 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

CD45: new jobs for an old acquaintance

2001 • 286 citations

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1998 • 268 citations

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

2002 • 263 citations

Sweet 'n' sour: the impact of differential glycosylation on T cell responses

2002 • 258 citations

Regulation of CD27 expression on subsets of mature T-lymphocytes.

1993 • 247 citations

Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation

2004 • 234 citations

Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells

2005 • 216 citations

Isolation and characterization of leukosialin, a major sialoglycoprotein on human leukocytes.

1986 • 196 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

The Macrophage C-type Lectin Specific for Galactose/N-Acetylgalactosamine Is an Endocytic Receptor Expressed on Monocyte-derived Immature Dendritic Cells

2002 • 163 citations

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

1996 • 132 citations

Dexamethasone Induces IL‐10‐Producing Monocyte‐Derived Dendritic Cells with Durable Immaturity

2005 • 124 citations

Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4⁺ T cells in vitro

1997 • 123 citations

Altered CD45 expression and disease

2006 • 120 citations

Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45

1999 • 117 citations

Regulated Expression of the Pathogen Receptor Dendritic Cell-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin in THP-1 Human Leukemic Cells, Monocytes, and Macrophages

2004 • 112 citations

Molecular Cloning and Characterization of a Novel Mouse Macrophage C-type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1

2002 • 110 citations

Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45

2005 • 107 citations

CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.

1997 • 86 citations

CD45 ligation induces programmed cell death in T and B lymphocytes.

1996 • 84 citations

An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells

2005 • 63 citations

CD45 alternative exon expression in murine and human CD4+ T cell subsets.

1992 • 52 citations

Identification of Sialoadhesin as a Dominant Lymph Node Counter-receptor for Mouse Macrophage Galactose-type C-type Lectin 1

2004 • 51 citations

Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells

2005 • 48 citations

Structural study of the O‐linked sugar chains of human leukocyte tyrosine phosphatase CD45

1998 • 34 citations

Anti-CD45RB Monoclonal Antibody-Mediated Transplantation Tolerance

2001 • 29 citations

Human CD45RC specificity. A novel marker for T cells at different maturation and activation stages.

1994 • 29 citations

Apoptosis Mediated Through CD45 Is Independent of Its Phosphatase Activity and Association with Leukocyte Phosphatase-Associated Phosphoprotein

2002 • 24 citations

CD45 regulates apoptosis in peripheral T lymphocytes

2006 • 15 citations

Alterations in CD45 Glycosylation Pattern Accompanying Different Cell Proliferation States

1994 • 14 citations