Dectin-1: a signalling non-TLR pattern-recognition receptor

Evolving concepts of rheumatoid arthritis

2003 • 3,428 citations

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 • 2,188 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Nonfilamentous C. albicans Mutants Are Avirulent

1997 • 1,769 citations

Immunity to fungal infections

2011 • 1,737 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

2003 • 1,593 citations

A new receptor for β-glucans

2001 • 1,498 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

An endothelial receptor for oxidized low-density lipoprotein

1997 • 1,334 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Dectin-1 Mediates the Biological Effects of β-Glucans

2003 • 1,167 citations

Pattern Recognition Receptors

2002 • 1,139 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

Natural regulatory T cells in infectious disease

2005 • 1,035 citations

The C‐type lectin superfamily in the immune system

1998 • 1,022 citations

Regulation of Phagosome Maturation by Signals from Toll-Like Receptors

2004 • 982 citations

Dectin-1 Is A Major β-Glucan Receptor On Macrophages

2002 • 964 citations

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

1998 • 892 citations

Dynamics of cell wall structure inSaccharomyces cerevisiae

2002 • 883 citations

CD36 is a sensor of diacylglycerides

2005 • 846 citations

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

2005 • 844 citations

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

2003 • 822 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Immunity to fungal infections

2003 • 731 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

2000 • 663 citations

NLRs join TLRs as innate sensors of pathogens

2005 • 663 citations

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

2002 • 652 citations

CD14 is required for MyD88-independent LPS signaling

2005 • 645 citations

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments

2005 • 638 citations

The β-Glucan Receptor, Dectin-1, Is Predominantly Expressed on the Surface of Cells of the Monocyte/Macrophage and Neutrophil Lineages

2002 • 627 citations

Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

2004 • 601 citations

Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18).

1996 • 589 citations

Immune functions encoded by the natural killer gene complex

2003 • 564 citations

Involvement of LOX-1 in Dendritic Cell-Mediated Antigen Cross-Presentation

2002 • 524 citations

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

2005 • 501 citations

Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages

1995 • 501 citations

Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.

1990 • 501 citations

The Contribution of the Toll-Like/IL-1 Receptor Superfamily to Innate and Adaptive Immunity to Fungal Pathogens In Vivo

2004 • 500 citations

Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans

2000 • 498 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

The Role of Toll‐like Receptor (TLR) 2 and TLR4 in the Host Defense against Disseminated Candidiasis

2002 • 478 citations

Fungal morphogenesis and host invasion

2002 • 470 citations

Mechanism by Which Orally Administered β-1,3-Glucans Enhance the Tumoricidal Activity of Antitumor Monoclonal Antibodies in Murine Tumor Models

2004 • 463 citations

Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning

2000 • 457 citations

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

2002 • 448 citations

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

2004 • 443 citations

NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

2002 • 431 citations

A novel glyco-conjugate vaccine against fungal pathogens

2005 • 426 citations

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

2005 • 423 citations

Toll-like Receptors Induce a Phagocytic Gene Program through p38

2003 • 411 citations

Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

1998 • 385 citations

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

1992 • 381 citations

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

2002 • 361 citations

Linkage of Adhesion, Filamentous Growth, and Virulence in Candida albicans to a Single Gene, INT1

1998 • 318 citations

Oral Delivery and Gastrointestinal Absorption of Soluble Glucans Stimulate Increased Resistance to Infectious Challenge

2005 • 316 citations

Characterization of the Human β-Glucan Receptor and Its Alternatively Spliced Isoforms

2001 • 315 citations

Alveolar Macrophage–mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor

2003 • 286 citations

Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors

2003 • 272 citations

The pathobiology of Paracoccidioides brasiliensis

2002 • 268 citations

The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells.

1999 • 264 citations

Dual function of C-type lectin-like receptors in the immune system

2003 • 253 citations

The human β‐glucan receptor is widely expressed and functionally equivalent to murine Dectin‐1 on primary cells

2005 • 244 citations

Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster.

1995 • 243 citations

Complement receptors and phagocytosis

1991 • 240 citations

B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans

2002 • 236 citations

Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide

2003 • 233 citations

The β-Glucan-Binding Lectin Site of Mouse CR3 (CD11b/CD18) and Its Function in Generating a Primed State of the Receptor That Mediates Cytotoxic Activation in Response to iC3b-Opsonized Target Cells

1999 • 228 citations

Macrophage Class A Scavenger Receptor-Mediated Phagocytosis ofEscherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro

2000 • 228 citations

(13)-beta-D-glucans and respiratory health: a review of the scientific evidence

2005 • 226 citations

A Novel Carbohydrate-Glycosphingolipid Interaction between a β-(1–3)-Glucan Immunomodulator, PGG-glucan, and Lactosylceramide of Human Leukocytes

1998 • 224 citations

Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1

2004 • 221 citations

Toll-like receptor-2 is essential in murine defenses against Candida albicans infections

2003 • 216 citations

Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

2000 • 214 citations

The Ly-49D Receptor Activates Murine Natural Killer Cells

1996 • 213 citations

Activation of Macrophages by Linear (1→3)-β-d-Glucans

2002 • 211 citations

Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans.

2002 • 181 citations

Normal Host Defense during Systemic Candidiasis in Mannose Receptor-Deficient Mice

2002 • 179 citations

Involvement of CD14, Toll-Like Receptors 2 and 4, and MyD88 in the Host Response to the Fungal PathogenCryptococcus neoformansIn Vivo

2004 • 178 citations

Innate Immunity to the Pathogenic Fungus Coccidioides posadasii Is Dependent on Toll-Like Receptor 2 and Dectin-1

2005 • 174 citations

T-cell receptor signal transmission: who gives an ITAM?

2003 • 174 citations

Toll-like receptors as an escape mechanism from the host defense

2004 • 174 citations

LOX-1 Supports Adhesion of Gram-Positive and Gram-Negative Bacteria

2001 • 169 citations

Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis

2004 • 168 citations

PGG-Glucan, a soluble β-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-κB-like factor in human PMN: Evidence for a glycosphingolipid β-(1,3)-glucan receptor

1999 • 163 citations

Human monocyte scavenger receptors are pattern recognition receptors for (1→3)-β-D-glucans

2002 • 158 citations

Zymosan—Induced Arthritis

1977 • 156 citations

cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.

1991 • 153 citations

Pneumocystis carinii Cell Wall β-Glucan Induces Release of Macrophage Inflammatory Protein-2 from Alveolar Epithelial Cells via a Lactosylceramide-mediated Mechanism

2003 • 148 citations

Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes

2004 • 145 citations

Molecular Mechanism of Tumor Necrosis Factor-α Production in 1→3-β-Glucan (Zymosan)-activated Macrophages

2001 • 135 citations

Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms

1995 • 135 citations

MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans

2005 • 134 citations

Expression of the β-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions

2004 • 131 citations

Lactosylceramide-enriched glycosphingolipid signaling domain mediates superoxide generation from human neutrophils

2002 • 129 citations

CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells

2004 • 126 citations

A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex

2001 • 119 citations

Ingestion of acapsular Cryptococcus neoformans occurs via mannose and beta-glucan receptors, resulting in cytokine production and increased phagocytosis of the encapsulated form

1995 • 117 citations

(1→3)-β-d-glucan — relationship to indoor air-related symptoms, allergy and asthma

2000 • 115 citations

Absence of the Macrophage Mannose Receptor in Mice Does Not Increase Susceptibility toPneumocystis cariniiInfection In Vivo

2003 • 115 citations

PneumocystisCell Wall β-Glucans Stimulate Alveolar Epithelial Cell Chemokine Generation through Nuclear Factor-κB–Dependent Mechanisms

2005 • 107 citations

Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), a possible adhesion receptor for yeasts

1990 • 103 citations

Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1

2001 • 102 citations

Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18).

1999 • 102 citations

Ligand Binding to the (1 → 3)-β-D-Glucan Receptor Stimulates NFκB Activation, but Not Apoptosis in U937 Cells

1998 • 101 citations

Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1

1985 • 98 citations

The function of human NK cells is enhanced by β‐glucan, a ligand of CR3 (CD11b/CD18)

1991 • 97 citations

Molecular and functional characterization of human Dectin-1

2002 • 97 citations

Early Resistance of Interleukin-10 Knockout Mice to Acute Systemic Candidiasis

1999 • 93 citations

Generation of Recombinant Fragments of CD11b Expressing the Functional β-Glucan-Binding Lectin Site of CR3 (CD11b/CD18)

1999 • 88 citations

Delayed Clearance ofPneumocystis cariniiInfection, Increased Inflammation, and Altered Nitric Oxide Metabolism in Lungs of Surfactant Protein–D Knockout Mice

2004 • 77 citations

Immunosuppressed Surfactant Protein A–Deficient Mice Have Increased Susceptibility toPneumocystis cariniiInfection

2001 • 75 citations

Enhanced Lung Injury and Delayed Clearance ofPneumocystis cariniiin Surfactant Protein A-Deficient Mice: Attenuation of Cytokine Responses and Reactive Oxygen-Nitrogen Species

2004 • 67 citations

PGG-Glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line

1997 • 65 citations

Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile

2004 • 61 citations

Cloning of human DECTIN-1 , a novel C-type lectin-like receptor gene expressed on dendritic cells

2001 • 52 citations

Pre-clinical safety evaluation of soluble glucan

1988 • 49 citations

SOLUBLE GLUCAN PROTECTS AGAINST ENDOTOXIN SHOCK IN THE RAT

1998 • 47 citations

Disseminated Candidiasis and Hepatic Malarial Infection in Mannose-Binding-Lectin-A-Deficient Mice

2002 • 41 citations

Molecular Characterization of Binding of Calcium and Carbohydrates by an Early Activation Antigen of Lymphocytes CD69

2003 • 34 citations

Characterization of Sugar Binding by Osteoclast Inhibitory Lectin

2004 • 31 citations

The Lectin-Like Domain of Complement Receptor 3 Protects Endothelial Barrier Function from Activated Neutrophils

2004 • 29 citations

Carboxymethylated beta‐1,3‐glucan inhibits the binding and degradation of acetylated low density lipoproteins in macrophages In Vitro and modulates their plasma clearance In Vivo

1996 • 22 citations

Chitotriosidase Deficiency in Survivors of Candida Sepsis

2002 • 17 citations

Identification and Characterization of an Alternatively Spliced Isoform of Mouse Langerin/CD207

2004 • 16 citations