Evidence for specific nucleocytoplasmic transport pathways used by leucine-rich nuclear export signals

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Structure and Function in the Nucleus

1998 • 925 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

THE HIV-1 REV PROTEIN

1998 • 716 citations

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1997 • 654 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

1997 • 435 citations

Nucleocytoplasmic Transport: The Last 200 Nanometers

1998 • 361 citations

Protein Sequence Requirements for Function of the Human T-Cell Leukemia Virus Type 1 Rex Nuclear Export Signal Delineated by a Novel In Vivo Randomization-Selection Assay

1996 • 356 citations

Transport into and out of the cell nucleus

1998 • 332 citations

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

1998 • 331 citations

Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1

1998 • 316 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.

1994 • 305 citations

Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

1993 • 290 citations

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2is regulated by phosphorylation

1998 • 270 citations

A human nucleoporin-like protein that specifically interacts with HIV Rev

1995 • 268 citations

Nuclear localization signals (NLS).

1993 • 249 citations

Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

1998 • 239 citations

Nuclear export signals and the fast track to the cytoplasm

1995 • 229 citations

The Specificity of the CRM1-Rev Nuclear Export Signal Interaction Is Mediated by RanGTP

1998 • 221 citations

Inhibition of HIV-1 Replication in Lymphocytes by Mutants of the Rev Cofactor eIF-5A

1996 • 218 citations

Nucleocytoplasmic transport of macromolecules

1997 • 191 citations

Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.

1992 • 181 citations

RNA Export

1995 • 181 citations

Inhibition of Human Immunodeficiency Virus Rev and Human T-Cell Leukemia Virus Rex Function, but Not Mason-Pfizer Monkey Virus Constitutive Transport Element Activity, by a Mutant Human Nucleoporin Targeted to Crm1

1998 • 170 citations

Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.

1995 • 156 citations

Nucleoporins Nup98 and Nup214 Participate in Nuclear Export of Human Immunodeficiency Virus Type 1 Rev

1999 • 154 citations

Two-way trafficking with Ran

1998 • 142 citations

Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

1992 • 114 citations

Overexpression of the Nucleoporin CAN/NUP214 Induces Growth Arrest, Nucleocytoplasmic Transport Defects, and Apoptosis

1998 • 113 citations

RNA TRANSPORT

1997 • 110 citations

Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.

1994 • 108 citations

Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN.

1996 • 85 citations

Interaction of the HIV-1 Rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5

1998 • 80 citations

Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.

1996 • 77 citations

The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal

1996 • 67 citations

Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding

1995 • 66 citations

A cytosolic activity distinct from Crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells

1998 • 48 citations

Intracellular Expression of Cellular eIF-5A Mutants Inhibits HIV-1 Replication in Human T Cells: A Feasibility Study

1996 • 32 citations

Tolerance of Diverse Amino Acid Substitutions at Conserved Positions in the Nuclear Export Signal (NES) of HIV-1 Rev

1998 • 24 citations

Expression of Chimeric Neo-Rev Response Element Sequences Interferes with Rev-Dependent HIV-1 Gag Expression

1992 • 12 citations

7 The molecular biology of human T-cell leuketnia viruses

1993 • 7 citations