Intracellular Expression of Cellular eIF-5A Mutants Inhibits HIV-1 Replication in Human T Cells: A Feasibility Study

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDS

1984 • 1,429 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5

1982 • 936 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene.

1988 • 462 citations

Complete Nucleotide Sequences of Functional Clones of the AIDS Virus

1987 • 348 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

1993 • 290 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

A human nucleoporin-like protein that specifically interacts with HIV Rev

1995 • 268 citations

Inhibition of HIV-1 Replication in Lymphocytes by Mutants of the Rev Cofactor eIF-5A

1996 • 218 citations

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions

1991 • 201 citations

Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients.

1996 • 196 citations

Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.

1992 • 181 citations

Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

1992 • 114 citations

Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes

1993 • 99 citations

Mechanism of action of regulatory proteins encoded by complex retroviruses.

1992 • 90 citations

Retroviral end-point titer is not predictive of gene transfer efficiency: implications for vector production.

1995 • 74 citations

A Molecular Genetic Intervention for AIDS—Effects of a Transdominant Negative Form of Rev. Hughes Medical Institute Research Laboratories, Ann Arbor, Michigan

1994 • 63 citations

RevM10-Mediated Inhibition of HIV-1 Replication in Chronically Infected T Cells

1995 • 50 citations

Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins

1991 • 46 citations

Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes.

1994 • 42 citations

Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.

1986 • 41 citations

Genetic Modification of Human Peripheral Blood Lymphocytes with a Transdominant Negative Form of Rev: Safety and Toxicity

1995 • 28 citations

Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy

1995 • 27 citations

Genetic instability of a MoMLV-based antisense double-copy retroviral vector designed for HIV-1 gene therapy.

1995 • 20 citations

The genomic structure encoding human initiation factor eIF-5A

1994 • 13 citations