Overexpression of DNA Methyltransferase in Myoblast Cells Accelerates Myotube Formation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

1974 • 8,693 citations

Genomic sequencing.

1984 • 8,343 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES

1954 • 3,832 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

The essentials of DNA methylation

1992 • 960 citations

DNA methylation and gene activity

1988 • 904 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Plasticity of the Differentiated State

1985 • 839 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

DNA methylation and gene expression

1991 • 685 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera

1962 • 548 citations

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

1992 • 502 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1992 • 399 citations

Expression of functional acetylcholine receptor from cloned cDNAs

1984 • 366 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

DNA methylation and gene expression.

1991 • 291 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1993 • 255 citations

Isolation and characterization of the cDNA encoding human DNA methyltransferase

1992 • 250 citations

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.

1990 • 237 citations

Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting.

1992 • 228 citations

B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence

1994 • 175 citations

Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation.

1986 • 175 citations

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.

1993 • 160 citations

Dynamics of demethylation and activation of the α-actin gene in myoblasts

1990 • 159 citations

Growth regulation of mouse DNA methyltransferase gene expression

1991 • 137 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Establishment of de novo DNA methylation patterns

1990 • 129 citations

Developmental activation of the H-2K gene is correlated with an increase in DNA methylation

1983 • 115 citations

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

1990 • 104 citations

Enzymic removal of 5-methylcytosine from DNA by a human DNA-glycosylase

1993 • 69 citations

Enhancement of reporter gene de novo methylation by DNA fragments from the alpha-fetoprotein control region.

1994 • 69 citations

Primary DNA Sequence Determines Sites of Maintenance and De Novo Methylation by Mammalian DNA Methyltransferases

1986 • 65 citations

Induction of myogenic differentiation by an expression vector encoding the DNA methyltransferase cDNA sequence in the antisense orientation.

1992 • 64 citations

Transient DNA demethylation in differentiating mouse myoblasts correlates with higher activity of 5-methyldeoxycytidine excision repair

1994 • 56 citations

Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells.

1985 • 51 citations

Mammalian DNA methyltransferases prefer poly(dI-dC) as substrate.

1986 • 50 citations

Human myotube differentiation in vitro in different culture conditions

1986 • 50 citations

The application of the diacetyl reaction to the estimation of creatine in urine

1953 • 48 citations

MyoD1 promoter autoregulation is mediated by two proximal E-boxes

1994 • 48 citations

Gene structure and transcription in mouse cells with extensively demethylated DNA.

1989 • 47 citations

Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect

1985 • 45 citations

Primary DNA sequence determines sites of maintenance and de novo methylation by mammalian DNA methyltransferases.

1986 • 43 citations

An avian 40 KDa nucleoprotein binds preferentially to a promoter sequence containing one single pair of methylated CpG

1991 • 43 citations

Expression of the Apolipoprotein E Gene in a Human Macrophage-Like Cell Line, THP-1

1989 • 34 citations

Characterisation of a genomic clone covering the structural mouse MyoD1 gene and its promoter region

1991 • 30 citations

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase

1991 • 26 citations

A Taq I polymorphism for the human transforming growth factor alpha gene (TGFA)

1987 • 20 citations

Dimethyl sulfoxide-inducible cytoplasmic factor involved in erythroid differentiation in mouse erythroleukemia (Friend) cells.

1987 • 20 citations

DNA-cytosine-5-methyltransferase from P815 mouse mastocytoma cells: “Maintenance” and “de novo” activities are carried out by the same enzyme molecule

1984 • 19 citations

Preferential binding of DNA methyltransferase and increased de novo methylation of deoxyinosine containing DNA

1986 • 18 citations

Brefeldin A Inhibits Muscle-Specific Gene Expression during Differentiation in C2C12 Myoblasts

1993 • 17 citations