In Search of the Pathways for Light-Induced Pacemaker Resetting in the Suprachiasmatic Nucleus

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

A functional analysis of circadian pacemakers in nocturnal rodents

1976 • 2,105 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

A functional analysis of circadian pacemakers in nocturnal rodents

1976 • 1,638 citations

A retinohypothalamic projection in the rat

1972 • 1,255 citations

Calcium regulation of neuronal gene expression

2001 • 1,003 citations

Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

1997 • 883 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock

2001 • 873 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting

2002 • 805 citations

The circadian visual system, 2005

2005 • 766 citations

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

1997 • 763 citations

Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections

2001 • 719 citations

Resetting the Biological Clock: Mediation of Nocturnal Circadian Shifts by Glutamate and NO

1994 • 570 citations

The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei

2002 • 541 citations

Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

2001 • 533 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus

1990 • 523 citations

Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms

1984 • 520 citations

An autoradiographic and electron microscopic study of retino-hypothalamic connections

1972 • 489 citations

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

2001 • 466 citations

The jun and fos protein families are both required for cell cycle progression in fibroblasts.

1991 • 442 citations

mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

2001 • 376 citations

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

1998 • 364 citations

The Ventral Lateral Geniculate Nucleus and the Intergeniculate Leaflet: Interrelated Structures in the Visual and Circadian Systems

1997 • 362 citations

Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms

2000 • 343 citations

GABA Synchronizes Clock Cells within the Suprachiasmatic Circadian Clock

2000 • 331 citations

The role of glutamate in the photic regulation of the suprachiasmatic nucleus

1996 • 319 citations

Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract

1988 • 314 citations

Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus).

1991 • 308 citations

Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements

1995 • 300 citations

Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei

1999 • 282 citations

Ca2+/cAMP Response Element-binding Protein (CREB)-dependent Activation of Per1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock

2003 • 280 citations

Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock

2002 • 263 citations

Inhibition of Light- or Glutamate-InducedmPer1Expression Represses the Phase Shifts into the Mouse Circadian Locomotor and Suprachiasmatic Firing Rhythms

1999 • 262 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro

1992 • 251 citations

Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene

2001 • 251 citations

Resetting the Biological Clock: Mediation of Nocturnal CREB Phosphorylation via Light, Glutamate, and Nitric Oxide

1997 • 243 citations

Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro

2000 • 240 citations

Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light

1999 • 237 citations

A light-independent oscillatory gene mPer3 in mouse SCN and OVLT

1998 • 234 citations

A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock

1998 • 229 citations

Expression ofPeriodGenes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker

2001 • 225 citations

Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: Evidence for an internal coincidence timer

2002 • 224 citations

Differential Resynchronisation of Circadian Clock Gene Expression within the Suprachiasmatic Nuclei of Mice Subjected to Experimental Jet Lag

2002 • 217 citations

Neuropeptides phase shift the mammalian circadian pacemaker

1995 • 215 citations

Regulation of jun -B Messenger RNA and AP-1 Activity by Light and a Circadian Clock

1992 • 215 citations

Luminance coding in a circadian pacemaker: the suprachiasmatic nucleus of the rat and the hamster

1986 • 213 citations

Signaling in the suprachiasmatic nucleus: selectively responsive and integrative

2002 • 210 citations

Assembling a Clock for All Seasons: Are There M and E Oscillators in the Genes?

2001 • 208 citations

PACAP and glutamate are co‐stored in the retinohypothalamic tract

2000 • 206 citations

Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts

2002 • 206 citations

Light Responsiveness of the Suprachiasmatic Nucleus: Long-Term Multiunit and Single-Unit Recordings in Freely Moving Rats

1998 • 200 citations

Intracellular electrophysiological study of suprachiasmatic nucleus neurons in rodents: inhibitory synaptic mechanisms.

1992 • 191 citations

Block of c‐Fos and JunB Expression by Antisense Oligonucleotides Inhibits Light‐induced‐Phase Shifts of the Mammalian Circadian Clock

1995 • 190 citations

PACAP and glutamate are co-stored in the retinohypothalamic tract

2000 • 175 citations

Activation of NMDA Receptors in the Suprachiasmatic Nucleus Produces Light-Like Phase Shifts of the Circadian ClockIn Vivo

1999 • 173 citations

Pituitary adenylyl cyclase-activating peptide: A pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock

1999 • 170 citations

Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice

2000 • 166 citations

Dissociation between Light-Induced Phase Shift of the Circadian Rhythm and Clock Gene Expression in Mice Lacking the Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor

2001 • 155 citations

CREB in the Mouse SCN: A Molecular Interface Coding the Phase-Adjusting Stimuli Light, Glutamate, PACAP, and Melatonin for Clockwork Access

1998 • 154 citations

Melanopsin, Ganglion-Cell Photoreceptors, and Mammalian Photoentrainment

2003 • 153 citations

Pituitary Adenylate Cyclase Activating Peptide Phase Shifts Circadian Rhythms in a Manner Similar to Light

1999 • 152 citations

Complex circadian regulation of pineal melatonin and wheel-running in Syrian hamsters

1994 • 152 citations

Robust Circadian Rhythmicity of Per1 and Per2 Mutant Mice in Constant Light, and Dynamics of Per1 and Per2 Gene Expression under Long and Short Photoperiods

2002 • 146 citations

Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, Fos expression and creb phosphorylation in the hamster suprachiasmatic nucleus

1996 • 143 citations

The p42/44 Mitogen-activated Protein Kinase Pathway Couples Photic Input to Circadian Clock Entrainment

2002 • 143 citations

Gradients in the circadian expression of Per1 and Per2 genes in the rat suprachiasmatic nucleus

2002 • 139 citations

Responses of neurones of the rat suprachiasmatic nucleus to retinal illumination under photopic and scotopic conditions

2000 • 138 citations

Vasoactive intestinal polypeptide (VIP) phase‐shifts the rat suprachiasmatic nucleus clock in vitro

2001 • 135 citations

Differences in colocalization between Fos and PHI, GRP, VIP and VP in neurons of the rat suprachiasmatic nucleus after a light stimulus during the phase delay versus the phase advance period of the night

1996 • 134 citations

Efferent projections of the intergeniculate leaflet and the ventral lateral geniculate nucleus in the rat

2000 • 133 citations

Intracellular electrophysiological study of suprachiasmatic nucleus neurons in rodents: excitatory synaptic mechanisms.

1991 • 128 citations

Calbindin-D28K cells in the hamster SCN express light-induced Fos

1996 • 128 citations

Response curve, free-running period, and activity time in circadian locomotor rhythm of rats.

1985 • 127 citations

Role of Brain-Derived Neurotrophic Factor in the Circadian Regulation of the Suprachiasmatic Pacemaker by Light

2000 • 122 citations

Gastrin-Releasing Peptide Mediates Photic Entrainable Signals to Dorsal Subsets of Suprachiasmatic Nucleus via Induction ofPeriod Gene in Mice

2002 • 113 citations

Rapid Resetting of the Mammalian Circadian Clock

1999 • 113 citations

The visual properties of rat and cat suprachiasmatic neurones

1980 • 111 citations

A Screen for Genes Induced in the Suprachiasmatic Nucleus by Light

1998 • 110 citations

Membrane properties and synaptic inputs of suprachiasmatic nucleus neurons in rat brain slices.

1997 • 104 citations

Phase-dependent responses of Per1 and Per2 genes to a light-stimulus in the suprachiasmatic nucleus of the rat

2000 • 103 citations

Subcellular distribution of 5‐HT_1b and 5‐HT₇ receptors in the mouse suprachiasmatic nucleus

2001 • 103 citations

Gastrin-Releasing Peptide Phase-Shifts Suprachiasmatic Nuclei Neuronal RhythmsIn Vitro

2000 • 100 citations

Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus

2000 • 99 citations

Neuropeptide Y and optic chiasm stimulation of affect suprachiasmatic nucleus circadian function in vitro

1993 • 97 citations

Masking by light in hamsters with SCN lesions

1999 • 93 citations

Additive effect of mPer1 and mPer2 antisense oligonucleotides on light-induced phase shift

2001 • 93 citations

Differential cAMP Gating of Glutamatergic Signaling Regulates Long-Term State Changes in the Suprachiasmatic Circadian Clock

2000 • 92 citations

Comparison of visual sensitivity for suppression of pineal melatonin and circadian phase-shifting in the golden hamster

1991 • 92 citations

Serotonergic Modulation of Retinal Input to the Mouse Suprachiasmatic Nucleus Mediated by 5-HT1B and 5-HT7 Receptors

2001 • 92 citations

NMDA‐evoked calcium transients and currents in the suprachiasmatic nucleus: gating by the circadian system

2001 • 91 citations

Vasoactive intestinal polypeptide induces per1 and per2 gene expression in the rat suprachiasmatic nucleus late at night

2002 • 89 citations

Involvement of calcium–calmodulin protein kinase but not mitogen‐activated protein kinase in light‐induced phase delays and Per gene expression in the suprachiasmatic nucleus of the hamster

2001 • 84 citations

Circadian and photic regulation of immediate-early gene expression in the hamster suprachiasmatic nucleus

1999 • 84 citations

Circadian modulation of membrane properties in slices of rat suprachiasmatic nucleus

1998 • 83 citations

The direct retinal projection to VIP neuronal elements in the rat SCN

1993 • 80 citations

Correlative Association betweenN-Methyl-d-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters

2000 • 79 citations

Pituitary adenylate cyclase-activating polypeptide induces period1 and period2 gene expression in the rat suprachiasmatic nucleus during late night

2001 • 78 citations

Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock

1993 • 78 citations

Spontaneous rhythm in c-Fos immunoreactivity in the dorsomedial part of the rat suprachiasmatic nucleus

1998 • 76 citations

The circadian system of c-fos deficient mice

1996 • 76 citations

Excitatory Mechanisms in the Suprachiasmatic Nucleus: The Role of AMPA/KA Glutamate Receptors

2002 • 75 citations

Neurons of the rat suprachiasmatic nucleus show a circadian rhythm in membrane properties that is lost during prolonged whole-cell recording1Published on the World Wide Web on 20 October 1998.1

1999 • 74 citations

Effects of Irradiance and Stimulus Duration on Early Gene Expression (Fos) in the Suprachiasmatic Nucleus: Temporal Summation and Reciprocity

2000 • 74 citations

Photic responses of suprachiasmatic area neurons in diurnal degus ( Octodon degus ) and nocturnal rats ( Rattus norvegicus )

1999 • 73 citations

Photically responsive neurons in the hypothalamus of a diurnal ground squirrel

1989 • 72 citations

Retinal Innervation of Calbindin-D28K Cells in the Hamster Suprachiasmatic Nucleus: Ultrastructural Characterization

2000 • 71 citations

Light and Glutamate-Induced Degradation of the Circadian Oscillating Protein BMAL1 during the Mammalian Clock Resetting

2000 • 70 citations

Effect of substance P on circadian rhythms of firing activity and the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro

1992 • 70 citations

Effects of nitric oxide synthase inhibitors onN-methyl-d-aspartate-induced phase delay of circadian rhythm of neuronal activity in the rat suprachiasmatic nucleus in vitro

1994 • 70 citations

Interconnections among nuclei of the subcortical visual shell: The intergeniculate leaflet is a major constituent of the hamster subcortical visual system

1998 • 70 citations

Neuropeptide Y in the mammalian circadian system: effects on light-induced circadian responses

2001 • 70 citations

Nitric oxide synthase inhibitor blocks light-induced phase shifts of the circadian activity rhythm, but not c-fos expression in the suprachiasmatic nucleus of the Syrian hamster

1995 • 68 citations

Photic Entrainment of the Mammalian Rhythm in Melatonin Production

1997 • 67 citations

Light induces expression of fos-related proteins within gastrin-releasing peptide neurons in the rat suprachiasmatic nucleus

1993 • 67 citations

A direct pretectosuprachiasmatic projection in the rat

1994 • 66 citations

Visualization of mPer1 transcription in vitro

2001 • 65 citations

Towards a molecular biology of the suprachiasmatic nucleus: photic and temporal regulation of c-fosgene expression

1995 • 64 citations

PACAP Potentiates L-Type Calcium Channel Conductance in Suprachiasmatic Nucleus Neurons by Activating the MAPK Pathway

2002 • 60 citations

Serotonergic Modulation of Photic Entrainment in the Syrian Hamster

2000 • 60 citations

Light‐induced c‐Fos Expression in the Mouse Suprachiasmatic Nucleus: Immunoelectron Microscopy Reveals Co‐localization in Multiple Cell Types

1997 • 59 citations

Membrane properties of rat suprachiasmatic nucleus neurons receiving optic nerve input.

1993 • 59 citations

Presence of neuronal nitric oxide synthase in the suprachiasmatic nuclei of mouse and rat

1996 • 54 citations

The effects of glutamate on membrane potential and discharge rate of suprachiasmatic neurons

1993 • 52 citations

Enhanced NMDA receptor activity in retinal inputs to the rat suprachiasmatic nucleus during the subjective night

2001 • 52 citations

Daily Rhythm of Spontaneous Immediate-Early Gene Expression in the Rat Suprachiasmatic Nucleus

1999 • 52 citations

KN-62, an inhibitor of Ca2+/ calmodulin kinase II, attenuates circadian responses to light

1994 • 52 citations

Stimuli which entrain the circadian clock of the neonatal Syrian hamster in vivo regulate the phosphorylation of the transcription factor CREB in the suprachiasmatic nucleus in vitro

1998 • 49 citations

Neurons containing gastrin-releasing peptide and vasoactive intestinal polypeptide are involved in the reception of the photic signal in the suprachiasmatic nucleus of the Syrian hamster: an immunocytochemical ultrastructural study

1998 • 48 citations

Distribution of substance P and neurokinin‐1 receptor immunoreactivity in the suprachiasmatic nuclei and intergeniculate leaflet of hamster, mouse, and rat

2001 • 48 citations

Nitric oxide synthase in the hypothalamic suprachiasmatic nucleus of rat: evidence from histochemistry, immunohistochemistry and Western blot; and colocalization with VIP

1995 • 48 citations

Synaptic input from the retina to the suprachiasmatic nucleus changes with the light‐dark cycle in the Syrian hamster.

1996 • 47 citations

cGMP-dependent protein kinase inhibitors block light-induced phase advances of circadian rhythms in vivo

1996 • 47 citations

Light‐induced c‐Fos expression in suprachiasmatic nuclei neurons targeting the paraventricular nucleus of the hamster hypothalamus: Phase dependence and immunochemical identification

2001 • 47 citations

GABAergic regulation of light-induced c-Fos immunoreactivity within the suprachiasmatic nucleus

1999 • 47 citations

Glutamatergic Induction of CREB Phosphorylation and Fos Expression in Primary Cultures of the Suprachiasmatic Hypothalamus In Vitro is Mediated by Co‐Ordinate Activity of NMDA and Non‐NMDA Receptors

1999 • 46 citations

The pituitary adenylate cyclase‐activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neurons

2001 • 45 citations

Substance P Plays a Critical Role in Photic Resetting of the Circadian Pacemaker in the Rat Hypothalamus

2001 • 45 citations

Photoperiod-dependent correlation between light-induced SCN c-fos expression and resetting of circadian phase

1996 • 45 citations

Effect of a nitric oxide synthase inhibitor, N-nitro-l-arginine methylester, on light-induced phase delay of circadian rhythm of wheel-running activity in golden hamsters

1995 • 43 citations

Effects of excitatory and inhibitory amino acids on neuronal discharges in the cultured suprachiasmatic nucleus

1993 • 43 citations

The Neuropeptide Y Y5 Receptor Mediates the Blockade of “Photic-Like” NMDA-Induced Phase Shifts in the Golden Hamster

2001 • 42 citations

Substance P receptor regulates the photic induction of Fos-like protein in the suprachiasmatic nucleus of Syrian hamsters

1996 • 40 citations

Light-Induced Phase Shifts in Onset and Offset of Running-Wheel Activity in the Syrian Hamster

1995 • 39 citations

c-Fos expression in the rat intergeniculate leaflet: photic regulation, co-localization with Fos-B, and cellular identification

1996 • 39 citations

Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses

1997 • 38 citations

Effects of Microinjections of Substance P Into the Suprachiasmatic Nucleus Region on Hamster Wheel-Running Rhythms

1997 • 37 citations

Presynaptic adenosine A1 receptors regulate retinohypothalamic neurotransmission in the hamster suprachiasmatic nucleus

2002 • 33 citations

Pituitary adenylate cyclase-activating polypeptide produces a phase shift associated with induction of mPer expression in the mouse suprachiasmatic nucleus

2002 • 33 citations

Putative excitatory amino acid projections to the suprachiasmatic nucleus in the rat

1996 • 30 citations

Involvement of glutamate release in substance P-induced phase delays of suprachiasmatic neuron activity rhythm in vitro

1999 • 29 citations

Calcium imaging in organotypic cultures of the rat suprachiasmatic nucleus

1994 • 28 citations

Circadian Behavior and Plasticity of Light-Induced c-fos Expression in SCN of tau Mutant Hamsters

1998 • 28 citations

Light-induced expression of transcription factor ICER (inducible cAMP early repressor) in rat suprachiasmatic nucleus is phase-restricted.

1996 • 27 citations

Histamine Phase Shifts the Hamster Circadian Pacemaker via an NMDA Dependent Mechanism

1998 • 24 citations

Physiological Response Properties of Cat Retinal Ganglion Cells Projecting to Suprachiasmatic Nucleus

2000 • 23 citations

Critical period for cycloheximide blockade of light-induced phase advances of the circadian locomotor activity rhythm in golden hamsters

1996 • 23 citations

Light-induced expression of transcription factor ICER (inducible cAMP early repressor) in rat suprachiasmatic nucleus is phase-restricted

1996 • 22 citations

Amino-terminal processing of the catalytic subunit from Na(+)-K(+)-ATPase

1996 • 22 citations

Immunoreactive substance P is not part of the retinohypothalamic tract in the rat

2002 • 21 citations

The selective neurokinin 1 receptor antagonist R116301 modulates photic responses of the hamster circadian system

2001 • 20 citations

Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms

2002 • 20 citations

N-Methyl-d-aspartate microinjected into the suprachiasmatic nucleus mimics the phase-shifting effects of light in the diurnal Nile grass rat (Arvicanthis niloticus)

2002 • 19 citations

Light‐Induced Variations in AP‐1 Binding Activity and Composition in the Rat Suprachiasmatic Nucleus

1999 • 17 citations

A subpopulation of efferent neurons in the mouse suprachiasmatic nucleus is also light responsive

2002 • 16 citations

In vitro stimulation of c-Fos protein expression in the suprachiasmatic nucleus of hypothalamic slices

1996 • 11 citations

Light-Induced Resetting of the Circadian Pacemaker: Quantitative Analysis of Transient versus Steady-State Phase Shifts

2001 • 11 citations

Anatomical and temporal differences in the regulation of ZIF268 (NGFI-A) protein in the hamster and mouse suprachiasmatic nucleus

2002 • 9 citations

Entrainment impaired, masking spared: an apparent genetic abnormality that prevents circadian rhythm entrainment to 24-h lighting cycles in California mice

2002 • 6 citations