Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior

Clustering Algorithms

1975 • 6,014 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

1990 • 1,788 citations

Suprachiasmatic nucleus : the mind's clock

1991 • 1,730 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Clustering Algorithms.

1976 • 1,518 citations

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

1995 • 1,437 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

The chi square periodogram: Its utility for analysis of circadian rhythms

1978 • 968 citations

Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus.

1979 • 968 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

1997 • 851 citations

A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms

1996 • 776 citations

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

2000 • 681 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

2000 • 661 citations

Mouse Chimæras Developed from Fused Eggs

1961 • 567 citations

Molecular Genetics of Circadian Rhythms in Mammals

2000 • 541 citations

Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain

1987 • 538 citations

Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei

1997 • 504 citations

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

1998 • 376 citations

Origin of Pigment Cells from the Neural Crest in the Mouse Embryo

1947 • 363 citations

GABA Synchronizes Clock Cells within the Suprachiasmatic Circadian Clock

2000 • 331 citations

Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms

1992 • 326 citations

Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei

2000 • 281 citations

The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker.

1987 • 262 citations

Forward and Reverse Genetic Approaches to Behavior in the Mouse

1994 • 243 citations

Chimeras in Developmental Biology

1984 • 235 citations

Chapter 8 Entrainment pathways and the functional organization of the circadian system

1996 • 223 citations

A fine-grained anatomical analysis of the role of the rat suprachiasmatic nucleus in circadian rhythms of feeding and drinking

1979 • 213 citations

Host-guided migration allows targeted introduction of neurons into the embryonic brain

1995 • 206 citations

Light Responsiveness of the Suprachiasmatic Nucleus: Long-Term Multiunit and Single-Unit Recordings in Freely Moving Rats

1998 • 200 citations

Circadian periods of single suprachiasmatic neurons in rats

1998 • 183 citations

Relationship of genotype and degree of chimerism in coat color to sex ratios and gametogenesis in chimeric mice

1971 • 161 citations

The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of Kit

1997 • 159 citations

Suprachiasmatic pacemaker organization analyzed by viral transynaptic transport

1999 • 157 citations

Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus

1982 • 145 citations

Immortal Time: Circadian Clock Properties of Rat Suprachiasmatic Cell Lines

1999 • 133 citations

GFP fluorescence reports Period 1 circadian gene regulation in the mammalian biological clock

2000 • 131 citations

Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates

1997 • 130 citations

Localization of a Suprachiasmatic Nucleus Subregion Regulating Locomotor Rhythmicity

1999 • 127 citations

Dispersed cell suspensions of fetal SCN restore circadian rhythmicity in SCN-lesioned adult hamsters

1990 • 126 citations

Molecular Genetic Neuroscience

1983 • 121 citations

TWO ADDITIONS TO HIERARCHICAL CLUSTER ANALYSIS†

1972 • 119 citations

Molecular Cloning and Characterization of the HumanCLOCKGene: Expression in the Suprachiasmatic Nuclei

1999 • 119 citations

Electrophysiological and morphological heterogeneity of neurons in slices of rat suprachiasmatic nucleus

1998 • 119 citations

Chimeras and mosaics in mouse mutant analysis

1998 • 115 citations

Multiunit activity recordings in the suprachiasmatic nuclei: in vivo versus in vitro models

1997 • 108 citations

Chimeras in developmental biology

1984 • 105 citations

Multiple regulatory elements result in regional specificity in circadian rhythms of neuropeptide expression in mouse SCN

1999 • 89 citations

Circadian rhythmicity after neural transplant to hamster third ventricle: specificity of suprachiasmatic nuclei

1989 • 89 citations

Cell lineage analysis of cerebellar Purkinje cells in mouse chimeras

1981 • 78 citations

Vasopressin neurotransmission and the control of circadian rhythms in the suprachiasmatic nucleus

1999 • 76 citations

Mosaic analysis of a Drosophila clock mutant

1983 • 72 citations

Effects of optic-tract regeneration on internal coupling in the circadian system of the cockroach

1983 • 63 citations

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression

1991 • 54 citations

Variability of chimaeras and mosaics

1978 • 52 citations

Temporal chimeras produced by hypothalamic transplants

1992 • 51 citations

Molecular genetic neuroscience

1982 • 48 citations

NGF-induced motoneuron cell death depends on the genetic background and motoneuron sub-type

2000 • 47 citations

Brain and ganglion development from two genotypic classes of cells in allophenic mice

1976 • 45 citations

Circadian locomotor rhythms in aged hamsters following suprachiasmatic transplant

1995 • 41 citations

Morphological Correlates of Circadian Rhythm Restoration Induced by Transplantation of the Suprachiasmatic Nucleus in Hamsters

1994 • 41 citations

The role ofClock in the developmental expression of neuropeptides in the suprachiasmatic nucleus

2000 • 40 citations

The Suprachiasmatic Nucleus

2008 • 34 citations

Intracellular distribution of transgenic bacterial β‐galactosidase in central nervous system neurons and neuroglia

1993 • 30 citations

Nonphotic phase-shifting in Clock mutant mice

2000 • 28 citations

Cell partitioning and mixing in the formation of the CNS: analysis of the cortical somatosensory barrels in chimeric mice

1987 • 28 citations

Effects of damage to SCN neurons and efferent pathways on circadian activity rhythms of hamsters

1993 • 27 citations

Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis

2000 • 12 citations

Asymmetrical electrical activity between the suprachiasmatic nuclei in vitro

1995 • 11 citations

Can a population of suprachiasmatic nucleus neurons with different period lengths produce a stable circadian rhythm?

1995 • 11 citations

Cell mixing in the spinal cords of mouse chimeras

1992 • 5 citations