Suppression of clofibrate-induction of peroxisomal and microsomal fatty acid-oxidizing enzymes by growth hormone and thyroid hormone in primary cultures of rat hepatocytes

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

The Effect of Peroxisome Prouferators on Microsomal. Peroxisomal, and Mitochondrial Enzyme Activities in the Liver and Kidney

1987 • 211 citations

Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone.

1992 • 207 citations

Peroxisome proliferation in primary cultures of rat hepatocytes

1983 • 178 citations

Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.

1987 • 177 citations

Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver

1988 • 162 citations

The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid.

1982 • 161 citations

The Rat Clofibrate-InducibleCYP4ASubfamily II. cDNA Sequence of IVA3, Mapping of theCyp4aLocus to Mouse Chromosome 4, and Coordinate and Tissue-Specific Regulation of theCYP4AGenes

1989 • 140 citations

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression.

1988 • 138 citations

THE SHORT‐ AND LONG‐TERM EFFECTS OF BEZAFIBRATE IN THE RAT*

1982 • 127 citations

Animal toxicity studies with ammonium perfluorooctanoate

1980 • 124 citations

Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate

1985 • 115 citations

Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.

1990 • 108 citations

Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha.

1990 • 105 citations

Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway

1993 • 104 citations

Quantitative Microscopy Comparison of Peroxisome Proliferation by the Lipid-Regulating Agent Gemfibrozil in Several Species

1984 • 96 citations

Pituitary Regulation of the Male-Specific Steroid 6β-Hydroxylase P-450 2a (gene product IIIA2) in Adult Rat Liver. Suppressive Influence of Growth Hormone and Thyroxine Acting at a Pretranslational Level

1990 • 86 citations

Regulation of liver-specific steroid metabolizing cytochromes P450: Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases

1992 • 83 citations

Expression of Rabbit Cytochromes P4504A Which Catalyze the ω-Hydroxylation of Arachidonic Acid, Fatty Acids, and Prostaglandins

1993 • 76 citations

The effect of hypolipidaemic agents on peroxisomal β-oxidation and mixed-function oxidase activities in primary cultures of rat hepatocytes. Relationship between induction of palmitoyl-CoA oxidation and lauric acid hydroxylation

1984 • 69 citations

Binding of human growth hormone to rat liver membranes: Lactogenic and somatotropic sites

1976 • 67 citations

Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal β-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver

1989 • 66 citations

Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomes

1986 • 59 citations

Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system.

1991 • 58 citations

On the mechanism of induction of microsomal cytochrome P450IVA1 and peroxisome proliferation in rat liver by clofibrate

1990 • 56 citations

Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats.

1994 • 53 citations

Omega hydroxy fatty acid dehydrogenase

1961 • 51 citations

Characterization of cytochromes P450 in liver and kidney of rats treated with di‐(2‐ethylhexyl)phthalate

1993 • 51 citations

Hepatic effects of phthalate esters and related compounds--in vivo and in vitro correlations.

1986 • 42 citations

Elimination and Toxicity of Perfluorooctanoic Acid during Subchronic Administration in the Wistar Rat

1987 • 34 citations

Modulation of Hepatic Level of Microsomal Testosterone 7α-Hydroxylase, P-450a (P450IIA), by Thyroid Hormone and Growth Hormone in Rat Liver1

1990 • 30 citations

Effects of testosterone, hypophysectomy and growth hormone treatment on clofibrate induction of peroxisomal β-oxidation in female rat liver

1994 • 26 citations

Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes.

1993 • 22 citations

Assay of fatty acid ω-hydroxylation using high-performance liquid chromatography with fluorescence labeling reagent, 3-bromomethyl-7-methoxy-1,4-benzoxazin-2-one (BrMB)

1991 • 18 citations

Growth hormone acts at a pretranslational level in hepatocyte cultures

1983 • 15 citations

Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes

1993 • 13 citations

Regulation of Growth Hormone Receptor Turnover by Growth Hormone

1990 • 13 citations

The Modulation by 3,5,3′-Triiodothyronine (T₃) of Pituitary T₃Nuclear Receptors in Hypothyroid Rats Is Inhibited by Cycloheximide*

1987 • 8 citations

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