The Immunobiology of Inductive Anti-CD40L Therapy in Transplantation: Allograft Acceptance is Not Dependent Upon the Deletion of Graft-Reactive T Cells

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Requirement for CD154 in the progression of atherosclerosis

1999 • 437 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo

2000 • 370 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.

1980 • 235 citations

Treatment of Allograft Recipients with Donor-Specific Transfusion and Anti-CD154 Antibody Leads to Deletion of Alloreactive CD8+ T Cells and Prolonged Graft Survival in a CTLA4-Dependent Manner

2000 • 216 citations

BLOCKADE OF THE CD40-CD40 LIGAND PATHWAY POTENTIATES THE CAPACITY OF DONOR-DERIVED DENDRITIC CELL PROGENITORS TO INDUCE LONG-TERM CARDIAC ALLOGRAFT SURVIVAL1,2

1997 • 215 citations

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

2000 • 202 citations

Cd40 Ligand (Cd154) Triggers a Short-Term Cd4+ T Cell Activation Response That Results in Secretion of Immunomodulatory Cytokines and Apoptosis

2000 • 187 citations

ARE Th2 HELPER T LYMPHOCYTES BENEFICIAL, DELETERIOUS, OR IRRELEVANT IN PROMOTING ALLOGRAFT SURVIVAL?1

1997 • 170 citations

PROLONGED SURVIVAL OF MOUSE SKIN ALLOGRAFTS IN RECIPIENTS TREATED WITH DONOR SPLENOCYTES AND ANTIBODY TO CD40 LIGAND1

1997 • 169 citations

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis

2000 • 154 citations

De Novo Autoimmunity to Cardiac Myosin After Heart Transplantation and Its Contribution to the Rejection Process

1999 • 147 citations

Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells.

1997 • 112 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

PREVENTION OF CHRONIC REJECTION IN MOUSE AORTIC ALLOGRAFTS BY COMBINED TREATMENT WITH CTLA4-Ig AND ANTI-CD40 LIGAND MONOCLONAL ANTIBODY1,2

1997 • 96 citations

Immunobiology of Allograft Rejection in the Absence of IFN-γ: CD8+ Effector Cells Develop Independently of CD4+ Cells and CD40-CD40 Ligand Interactions

2001 • 92 citations

HIGH-RESOLUTION CHARACTERIZATION OF CYTOKINE-PRODUCING ALLOREACTIVITY IN NAIVE AND ALLOGRAFT-PRIMED MICE1,2

1998 • 89 citations

The role of T cell apoptosis in transplantation tolerance

2000 • 83 citations

A TECHNIQUE OF CERVICAL HETEROTOPIC HEART TRANSPLANTATION IN MICE

1991 • 82 citations

PREVENTION OF MURINE CARDIAC ALLOGRAFT REJECTION WITH GALLIUM NITRATE

1996 • 78 citations

The Future of Organ and Tissue Transplantation

1999 • 77 citations

T Cell Costimulatory Blockade

1999 • 75 citations

Mobilization of T lymphocytes following cardiac transplantation. Evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection.

1992 • 72 citations

CARDIAC MYOSIN AUTOANTIBODIES AND ACUTE REJECTION AFTER HEART TRANSPLANTATION IN PATIENTS WITH DILATED CARDIOMYOPATHY

2000 • 66 citations

FACTORS CONTRIBUTING TO THE DEVELOPMENT OF CHRONIC REJECTION IN HETEROTOPIC RAT HEART TRANSPLANTATION1

1997 • 64 citations

CD40 Ligand Is Not Essential for Induction of Type 1 Cytokine Responses or Protective Immunity after Primary or Secondary Infection With Histoplasma capsulatum

1998 • 62 citations

MOBILIZATION OF T LYMPHOCYTES FOLLOWING CARDIAC TRANSPLANTATION

1992 • 62 citations

TRANSFORMING GROWTH FACTOR-?? AND INTERLEUKIN-10 SUBVERT ALLOREACTIVE DELAYED TYPE HYPERSENSITIVITY IN CARDIAC ALLOGRAFT ACCEPTOR MICE1

2000 • 45 citations

SKIN-SPECIFIC ALLOANTIGENS IN MINIATURE SWINE1

2001 • 43 citations

HELPER T LYMPHOCYTE UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS FOLLOWING TRANSIENT DEPLETION OF CD4-POSITIVE CELLS

1994 • 39 citations

Limiting dilution analysis for alloreactive, TCGF-secretory T cells. Two related LDA methods that discriminate between unstimulated precursor T cells and in vivo-alloactivated T cells.

1989 • 38 citations

LIMITING DILUTION ANALYSIS FOR ALLOREACTIVE, TCGF-SECRETORY T CELLS

1989 • 37 citations

CYTOKINE REGULATION OF CHRONIC CARDIAC ALLOGRAFT REJECTION: EVIDENCE AGAINST A ROLE FOR TH1 IN THE DISEASE PROCESS1

1999 • 37 citations

COSTIMULATION PATHWAYS IN HOST IMMUNE RESPONSES TO ALLOGENEIC HEPATOCYTES1,2

1998 • 34 citations

T cells are just dying to accept grafts

1999 • 33 citations

DEVELOPMENT AND EVALUATION OF A LIMITING DILUTION ANALYSIS TECHNIQUE THAT CAN DISCRIMINATE IN VIVO ALLOACTIVATED CYTOTOXIC T LYMPHOCYTES FROM THEIR NAIVE CTL PRECURSORS

1989 • 31 citations

TISSUE-SPECIFIC DIFFERENCES IN THE ESTABLISHMENT OF TOLERANCE

1994 • 25 citations

Tissue-specific differences in the establishment of tolerance. Tolerogenic effects of lung allografts in rats.

1994 • 25 citations

Control of immune pathology by IL-10-secreting regulatory T cells

1999 • 23 citations