EB 1089, a novel vitamin D Analog with strong antiproliferative and differentiation-inducing effects on target cells

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3

1996 • 233 citations

Effects of 1,25 dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells

1996 • 208 citations

Actions of vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3.

1995 • 206 citations

Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor

1995 • 201 citations

Mechanisms of Nuclear Signalling by Vitamin D3. Interplay with Retinoid and Thyroid Hormone Signalling

1995 • 186 citations

Vitamin D-regulated gene expression.

1993 • 181 citations

Vitamin D, a pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications

1994 • 176 citations

Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens

1994 • 150 citations

Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells

1994 • 116 citations

Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications

1995 • 107 citations

EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells

1993 • 106 citations

Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction.

1991 • 105 citations

1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells.

1995 • 99 citations

Growth-inhibitory effects of vitamin D analogues and retinoids on human pancreatic cancer cells

1996 • 93 citations

Role of vitamin D in bone resorption

1992 • 91 citations

A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo.

1993 • 90 citations

VITAMIN D DERIVATIVES IN COMBINATION WITH 9-cis RETINOIC ACID PROMOTE ACTIVE CELL DEATH IN BREAST CANCER CELLS

1995 • 90 citations

1α,25(OH)2Vitamin D3-Regulated Expression of the Eukaryotic Genome

2009 • 89 citations

1α,25-Dihydroxyvitamin D3 inhibits the invasive potential of human breast cancer cellsin vitro

1994 • 84 citations

1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3.

1993 • 81 citations

A Composite Element Binding the Vitamin D Receptor, Retinoid X Receptor α, and a Member of the CTF/NF-1 Family of Transcription Factors Mediates the Vitamin D Responsiveness of the c-fos Promoter

1996 • 67 citations

1,25-Dihydroxyvitamin D3 increases epidermal growth factor receptors and transforming growth factor beta-like activity in a bone-derived cell line.

1987 • 65 citations

The anti-proliferative effect of vitamin D3 analogues is not mediated by inhibition of the AP-1 pathway, but may be related to promoter selectivity.

1995 • 63 citations

Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089

1996 • 62 citations

Antitumor effect of 22-oxa-1α,25-dihydroxyvitamin D3 a potent angiogenesis inhibitor, on rat mammary tumors induced by 7, 12-dimethylbenz[a]anthracene

1991 • 59 citations

Metabolism of the vitamin D analog EB 1089: Identification of in vivo and in vitro liver metabolites and their biological activities∗

1997 • 56 citations

The 1,25-dihydroxyvitamin D3 (VD) analogues MC903, EB1089 and KH1060 activate the VD receptor: Homodimers show higher ligand sensitivity than heterodimers with retinoid X receptors

1994 • 55 citations

Differing shapes of 1α,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: A status report

1996 • 52 citations

Pharmacokinetic studies of vitamin D analogues: relationship to vitamin D binding protein (DBP)

1995 • 52 citations

Retinoic acid modulation of 1,25(OH)2 vitamin D3 receptors and bioresponse in bone cells: Species differences between rat and mouse

1985 • 44 citations

Cytotoxic effects of 1α,25-dihydroxyvitamin D3 and synthetic vitamin D3 analogues on a glioma cell line

1996 • 42 citations

Differential effects of 1,25-dihydroxyvitamin D3-analogs on osteoblast-like cells and onin vitro bone resorption

1995 • 42 citations

Steroid Hormone Modulation of Vitamin D Receptor Levels in Human MG-63 Osteosarcoma Cells

1994 • 40 citations

Inhibition of HT-29 human colon cancer growth under the renal capsule of severe combined immunodeficient mice by an analogue of 1,25-dihydroxyvitamin D3, DD-003.

1994 • 37 citations

Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells

1996 • 35 citations

Estrogen Regulation of the Nuclear 1,25- Dihydroxyvitamin D₃Receptor in Rat Liver and Kidney*

1991 • 34 citations

Inhibition of tumor production of granulocyte-macrophage colony-stimulating factor by 1 alpha, 25-dihydroxyvitamin D3 reduces tumor motility and metastasis.

1993 • 33 citations

Murine osteoblast interleukin 4 receptor expression: Upregulation by 1,25 dihydroxyvitamin D₃

1993 • 26 citations

Down-regulation of Laminin-Binding Integrins by 1α,25=Dihydroxyvitamin D₃in Human Melanoma Cells in Vitro

1998 • 24 citations

Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues.

1993 • 24 citations

Vitamin D and breast cancer: the therapeutic potential of new vitamin D analogues

1995 • 20 citations

Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase

1995 • 18 citations

Studies on two new vitamin D analogs, EB 1089 and KH 1060: Effects on bone resorption and osteoclast recruitment in vitro

1995 • 17 citations

The potent anti-proliferative effect of 20-EPI analogues of 1,25 dihydroxyvitamin D3 in human breast-cancer MCF-7 cells is related to promoter selectivity

1996 • 16 citations

A novel vitamin D analog with two double bonds in its side chain

1996 • 12 citations

The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications

1994 • 11 citations

Antiestrogens inhibit in vitro bone resorption stimulated by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogs EB1089 and KH1060.

1995 • 7 citations

EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type

1994 • 2 citations

Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation

1994 • 1 citations