Redefining Preeclampsia Using Placenta-Derived Biomarkers

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

2003 • 3,707 citations

Circulating angiogenic factors and the risk of preeclampsia*

2004 • 2,591 citations

Latest Advances in Understanding Preeclampsia

2005 • 2,482 citations

Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis

2007 • 2,326 citations

Inflammation in Atherosclerosis

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Preeclampsia: An excessive maternal inflammatory response to pregnancy

1999 • 1,855 citations

Preeclampsia: An endothelial cell disorder

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Soluble endoglin contributes to the pathogenesis of preeclampsia

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Pre-eclampsia

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The classification and definition of the hypertensive disorders of pregnancy

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J Soc Gynecol Investig

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Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)

1993 • 1,078 citations

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

2009 • 1,060 citations

ACOG PRACTICE BULLETIN

2009 • 1,049 citations

Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study Pre-eclampsia and cardiovascular disease later in life: who is at risk?

2001 • 1,022 citations

Inflammation and insulin resistance

2007 • 1,013 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Eclampsia in the United Kingdom

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Maternal Mortality From Preeclampsia/Eclampsia

2012 • 783 citations

Oxidative stress in the placenta

2004 • 770 citations

Diagnosis, Controversies, and Management of the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count

2004 • 769 citations

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

2003 • 758 citations

Subclassification of Preeclampsia

2003 • 741 citations

Placental bed spiral arteries in the hypertensive disorders of pregnancy

1991 • 665 citations

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate

2008 • 660 citations

Pregnancy-related mortality from preeclampsia and eclampsia

2001 • 626 citations

REVIEW ARTICLE: Immunology of Pre‐Eclampsia

2010 • 618 citations

Diagnosis and management of preeclampsia and eclampsia

2002 • 588 citations

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

2008 • 586 citations

Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications

1996 • 574 citations

Placental Stress and Pre-eclampsia: A Revised View

2009 • 525 citations

Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria

2003 • 519 citations

Linking oxidative stress to inflammation: Toll-like receptors

2010 • 489 citations

Cardiovascular Risk Factors in Children and Young Adults Born to Preeclamptic Pregnancies: A Systematic Review

2012 • 465 citations

Lipid peroxidation in pregnancy: New perspectives on preeclampsia

1989 • 458 citations

First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia

2004 • 450 citations

First-Trimester Prediction of Hypertensive Disorders in Pregnancy

2009 • 440 citations

Oxidative stress and endothelial dysfunction in hypertension

2011 • 432 citations

Maternal Preeclampsia and Neonatal Outcomes

2011 • 432 citations

Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies

2003 • 411 citations

An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia

2009 • 396 citations

Preeclampsia and Cardiovascular Disease Death

2010 • 392 citations

The discovery of placenta growth factor and its biological activity

2012 • 379 citations

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

2008 • 359 citations

Adverse Perinatal Outcomes and Risk Factors for Preeclampsia in Women With Chronic Hypertension

2008 • 355 citations

Persico MG.Isolation of a human placenta cDNA coding for a potein related to the vascular premeability factor

1991 • 352 citations

Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders

2003 • 350 citations

Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1

2006 • 332 citations

Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast

1997 • 331 citations

The frequency and severity of placental findings in women with preeclampsia are gestational age dependent

2003 • 326 citations

Impact of Preeclampsia and Gestational Hypertension on Birth Weight by Gestational Age

2002 • 321 citations

Regulation of vascular growth and function in the human placenta

2009 • 318 citations

Short- and Long-Term Changes in Plasma Inflammatory Markers Associated With Preeclampsia

2004 • 285 citations

Hypoxia and Reoxygenation: a Possible Mechanism for Placental Oxidative Stress in Preeclampsia

2006 • 283 citations

Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia

2011 • 270 citations

Tumor Necrosis Factor-α Inhibits Trophoblast Migration through Elevation of Plasminogen Activator Inhibitor-1 in First-Trimester Villous Explant Cultures

2004 • 262 citations

Vascular Changes in the Decidua Associated with Eclamptogenic Toxemia of Pregnancy

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Innate immunity, macrophage activation, and atherosclerosis

2007 • 251 citations

Long-Term Mortality After Preeclampsia

2005 • 246 citations

Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia

2007 • 243 citations

Soluble fms-Like Tyrosine Kinase 1 Is Increased in Preeclampsia But Not in Normotensive Pregnancies with Small-for-Gestational-Age Neonates: Relationship to Circulating Placental Growth Factor

2005 • 242 citations

Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms‐like tyrosine kinase 1 and soluble endoglin in the prediction of pre‐eclampsia: a systematic review and meta‐analysis

2012 • 240 citations

An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia

1980 • 234 citations

Pre-eclampsia and the hypertensive disorders of pregnancy

2003 • 232 citations

Placental isoprostane is significantly increased in preeclampsia

2000 • 232 citations

Circulating Microparticles in Normal Pregnancy and Pre-Eclampsia

2008 • 231 citations

Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia

2001 • 230 citations

The risk of maternal ischaemic heart disease after gestational hypertensive disease

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Is Preeclampsia More Than One Disease?

2004 • 226 citations

ON THE PATHOGENESIS OF PLACENTAL INFARCTS IN PRE‐ECLAMPSIA

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Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas

2002 • 209 citations

Learning From the Placenta

2010 • 202 citations

Elevated C‐reactive protein and pro‐inflammatory cytokines in Andean women with pre‐eclampsia

2001 • 196 citations

Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre‐eclampsia

1999 • 192 citations

Extra-placental Expression of Vascular Endothelial Growth Factor Receptor-1, (Flt-1) and Soluble Flt-1 (sFlt-1), by Peripheral Blood Mononuclear Cells (PBMCs) in Normotensive and Preeclamptic Pregnant Women

2004 • 192 citations

Localisation of Placenta Growth Factor (PlGF) in Human Term Placenta

1996 • 189 citations

Elevated Blood Pressure in Offspring Born Premature to Hypertensive Pregnancy

2010 • 188 citations

Geographic variation in incidence of hypertension in pregnancy

1988 • 185 citations

Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies

2002 • 184 citations

Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.

2001 • 180 citations

CLINICAL STUDY OF PRE‐ECLAMPSIA Part I

1955 • 180 citations

Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia

2005 • 175 citations

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction

2006 • 172 citations

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

2012 • 171 citations

Endothelial Function and Circulating Biomarkers Are Disturbed in Women and Children After Preeclampsia

2011 • 167 citations

Prediction of preeclampsia

1999 • 162 citations

Preeclampsia and future maternal health

2010 • 162 citations

The Immunomodulatory Role of Syncytiotrophoblast Microvesicles

2011 • 158 citations

VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis

2003 • 156 citations

Prediction of adverse outcomes by common definitions of hypertension in pregnancy

2001 • 146 citations

Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia

2005 • 145 citations

Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia

1999 • 142 citations

FACTOR-VIII CONSUMPTION IN PRE-ECLAMPSIA

1977 • 142 citations

Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein

1994 • 142 citations

Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion

2011 • 140 citations

Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling

2010 • 135 citations

Plasma and Urinary 8-iso-Prostane as An Indicator of Lipid Peroxidation in Pre-Eclampsia and Normal Pregnancy

1996 • 132 citations

Review article: Acute atherosis. A histopathological hallmark of immune aggression?

1988 • 131 citations

MORTALITY AND MORBIDITY ASSOCIATED WITH EARLY-ONSET PREECLAMPSIA

2000 • 129 citations

Automated assays for sVEGF R1 and PlGF as an aid in the diagnosis of preterm preeclampsia: a prospective clinical study

2009 • 127 citations

Angiogenic Factors in Superimposed Preeclampsia

2012 • 125 citations

Different profiles of circulating angiogenic factors and adipocytokines between early‐ and late‐onset pre‐eclampsia

2010 • 122 citations

Acute atherosis in pregnancies complicated by hypertension, small-for-gestational-age infants, and diabetes mellitus.

1991 • 120 citations

Placenta Growth Factor in Diabetic Wound Healing

2006 • 113 citations

Early-Onset Preeclampsia and the Prevalence of Postpartum Metabolic Syndrome

2009 • 112 citations

Management of Hypertension in Pregnancy: Executive Summary

1993 • 112 citations

Placental isoprostane is significantly increased in preeclampsia

2000 • 105 citations

Can placental growth factor in maternal circulation identify fetuses with placental intrauterine growth restriction?

2011 • 104 citations

Elevated Placental Growth Factor Levels Are Associated With Adverse Outcomes at Four-Year Follow-Up in Patients With Acute Coronary Syndromes

2006 • 104 citations

Secular trends in the epidemiology of pre‐eclampsia throughout 40 years in Norway: prevalence, risk factors and perinatal survival

2012 • 103 citations

Preeclampsia and future cardiovascular risk

2007 • 103 citations

Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism

2011 • 94 citations

Placental changes in a first trimester missed abortion in maternal systemic lupus erythematosus with antiphospholipid syndrome: A case report and review of the literature

1996 • 94 citations

CLINICAL OBSERVATIONS ON SOME ASPECTS OF HYDATIDIFORM MOLES

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Expression and function of placenta growth factor: implications for abnormal placentation

2003 • 93 citations

Circulating angiogenic factors and their association with birth outcomes in preeclampsia

2010 • 93 citations

Circulating Angiogenic Factors and Risk of Adverse Maternal and Perinatal Outcomes in Twin Pregnancies With Suspected Preeclampsia

2012 • 92 citations

Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity

2005 • 91 citations

Elevated level of free 8-iso-prostaglandin F2α in the decidua basalis of women with preeclampsia

1999 • 91 citations

Circulating angiogenic and antiangiogenic factors in women with eclampsia

2010 • 88 citations

Low Placental Growth Factor Across Pregnancy Identifies a Subset of Women With Preterm Preeclampsia

2012 • 87 citations

Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays

2011 • 87 citations

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

2010 • 85 citations

NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells

2005 • 82 citations

Alterations in Placental Growth Factor Levels before and after the Onset of Preeclampsia Are More Pronounced in Women with Early Onset Severe Preeclampsia

2007 • 82 citations

Oxygenation of the placental–fetal unit in humans

2011 • 81 citations

Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction

2006 • 80 citations

Early onset pre-eclampsia: recognition of underlying renal disease.

1987 • 78 citations

Obesity and inflammation: A new look at an old problem

2007 • 76 citations

Angiogenic factors and preeclampsia

2006 • 75 citations

Preeclampsia Related to a Functioning Extrauterine Placenta: Report of a Case and 25-Year Follow-up

1993 • 74 citations

Neutrophil Activation and C‐Reactive Protein Concentration in Preeclampsia

2003 • 73 citations

Prediction of Adverse Outcomes by Common Definitions of Hypertension in Pregnancy

2001 • 71 citations

Angiogenic biomarkers for prediction of maternal and neonatal complications in suspected preeclampsia

2012 • 69 citations

Management of Late Preterm and Early-Term Pregnancies Complicated by Mild Gestational Hypertension/Pre-Eclampsia

2011 • 67 citations

Autoantibody-Mediated Complement C3a Receptor Activation Contributes to the Pathogenesis of Preeclampsia

2012 • 66 citations

Glial Cell Missing 1 Regulates Placental Growth Factor (PGF) Gene Transcription in Human Trophoblast1

2007 • 64 citations

PlGF Repairs Myocardial Ischemia through Mechanisms of Angiogenesis, Cardioprotection and Recruitment of Myo-Angiogenic Competent Marrow Progenitors

2011 • 64 citations

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts

2010 • 61 citations

Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term

2002 • 61 citations

Maternal plasma soluble fms‐like tyrosine kinase‐1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia

2010 • 60 citations

Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia

2011 • 56 citations

Augmented oxidative stress as well as antioxidant capacity in maternal circulation in preeclampsia

2005 • 56 citations

Myocardial function in offspring 5–8years after pregnancy complicated by preeclampsia

2011 • 54 citations

Expression and Function of Placenta Growth Factor: Implications for Abnormal Placentation

2003 • 52 citations

The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome

2009 • 51 citations

Risk for Coronary Artery Disease and Morbid Preeclampsia: A Commentary

2005 • 51 citations

Acute Atherosis in Decidual Tissue: Not Associated with Systemic Oxidative Stress in Preeclampsia

2007 • 50 citations

Risks for Preeclampsia and Small for Gestational Age: Predictive Values of Placental Growth Factor, Soluble fms-like Tyrosine Kinase-1, and Inhibin A in Singleton and Multiple-Gestation Pregnancies

2012 • 50 citations

The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome

2010 • 43 citations

Molecular Regulation of Human Placental Growth Factor (PlGF) Gene Expression in Placental Villi and Trophoblast Cells is Mediated via the Protein Kinase A Pathway

2010 • 42 citations

An unexpected tail of VEGF and PlGF in pre-eclampsia

2011 • 41 citations

Immunohistologic demonstration of endothelial disruption in acute atherosis in pre-eclampsia

1993 • 41 citations

Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy

2009 • 36 citations

Increased neutrophil activation in diabetic pregnancy and in nonpregnant diabetic women.

1989 • 31 citations

The release of 15-hydroxyeicosatetraenoic acid by human placental trophoblast is increased in preeclampsia

1998 • 31 citations

Circulating predictive biomarkers in preeclampsia

2010 • 29 citations

Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 Is an Obesity-Relevant Endogenous Paracrine Adipokine

2011 • 27 citations

Adverse Adipose Phenotype and Hyperinsulinemia in Gravid Mice Deficient in Placental Growth Factor

2008 • 26 citations

Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery

2007 • 23 citations

Cardiovascular Biomarker Midregional Proatrial Natriuretic Peptide During and After Preeclamptic Pregnancies

2011 • 22 citations

Effects of Angiogenic Factors, Antagonists, and Podocyte Injury on Development of Proteinuria in Preeclampsia

2012 • 20 citations

Angiogenic imbalance and plasma lipid alterations in women with preeclampsia from a developing country

2012 • 18 citations

Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia – a case–control study

2011 • 17 citations

Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies

2012 • 17 citations

Increased production of 15-hydroxyeicosatetraenoic acid by placentae from pregnancies complicated by pregnancy-induced hypertension

1991 • 17 citations

Abstract P199: Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism

2011 • 13 citations

Deleted Work

1955 • 0 citations