An unexpected tail of VEGF and PlGF in pre-eclampsia

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

2003 • 3,707 citations

Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

2004 • 3,543 citations

Circulating angiogenic factors and the risk of preeclampsia*

2004 • 2,591 citations

Preeclampsia: An endothelial cell disorder

1989 • 1,848 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Molecular and biological properties of vascular endothelial growth factor

1999 • 1,174 citations

Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-κB Activation in Endothelial Cells

2001 • 722 citations

VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma.

2002 • 547 citations

Overexpression of the Soluble Vascular Endothelial Growth Factor Receptor in Preeclamptic Patients: Pathophysiological Consequences

2003 • 453 citations

First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia

2004 • 450 citations

VEGF165b, an Inhibitory Vascular Endothelial Growth Factor Splice Variant

2004 • 434 citations

Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies

2003 • 411 citations

Regulation of vascular permeability by vascular endothelial growth factors

2002 • 404 citations

Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia

2003 • 396 citations

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

2009 • 337 citations

Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor

2001 • 325 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

1993 • 317 citations

Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A₂ in endothelial cells via p42/p44 mitogen‐activated protein kinase

1997 • 258 citations

Regulation of microvascular permeability by vascular endothelial growth factors*

2002 • 250 citations

Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells.

1999 • 248 citations

Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop

2004 • 217 citations

Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia

1995 • 208 citations

Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1

1997 • 198 citations

Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre‐eclampsia

1999 • 192 citations

A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2

2006 • 188 citations

Placenta Growth Factor: Identification and Characterization of a Novel Isoform Generated by RNA Alternative Splicing

1997 • 188 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia

2005 • 175 citations

Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels

1996 • 167 citations

Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia

2000 • 167 citations

Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity

2008 • 161 citations

Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre‐eclampsia

1997 • 158 citations

Placental expression of vascular endothelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery

1997 • 156 citations

VEGF mRNA levels in placentae from pregnancies complicated by pre‐eclampsia

1996 • 152 citations

Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre‐eclampsia

1996 • 137 citations

Maternal plasma levels of cytokines in normal and preeclamptic pregnancies and their relationship with diastolic blood pressure and fibronectin levels

2003 • 136 citations

Vascular Endothelial Growth Factor Is Increased in Patients With Preeclampsia

1997 • 129 citations

Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia—a step forward but not the definitive answer

2009 • 127 citations

Vascular endothelial growth factor: Basic biology and clinical implications

1997 • 126 citations

Differential Expression of Vascular Endothelial Growth Factor (VEGF), Endocrine Gland Derived-VEGF, and VEGF Receptors in Human Placentas from Normal and Preeclamptic Pregnancies

2004 • 123 citations

Vascular endothelial growth factor is inactivated by binding to alpha 2-macroglobulin and the binding is inhibited by heparin.

1993 • 122 citations

Serum Levels of Vascular Endothelial Growth Factor in Preeclamptic and Normotensive Pregnancy

2000 • 117 citations

Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast

2008 • 116 citations

Angiogenesis and the placental environment

1995 • 112 citations

Variation in Detection of VEGF in Maternal Serum by Immunoassay and the Possible Influence of Binding Proteins

1997 • 102 citations

Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia

2009 • 99 citations

Maternal plasma vascular endothelial growth factor concentrations in normal and hypertensive pregnancies and their relationship to peripheral vascular resistance

2001 • 99 citations

Placental growth factor is a potent vasodilator of rat and human resistance arteries

2008 • 96 citations

Loss of placental growth factor protects mice against vascular permeability in pathological conditions

2002 • 95 citations

Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis

2006 • 94 citations

Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells

2003 • 94 citations

ZM323881, a Novel Inhibitor of Vascular Endothelial Growth Factor‐Receptor‐2 Tyrosine Kinase Activity

2002 • 86 citations

Increased endothelial monocyte chemoattractant protein-1 and interleukin-8 in preeclampsia

2002 • 82 citations

VEGF-A₁₆₅b Is Cytoprotective and Antiangiogenic in the Retina

2010 • 79 citations

VEGF expression in the placenta from pregnancies complicated by hypertensive disorders

2004 • 72 citations

Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia

2003 • 70 citations

VEGF via VEGF receptor-1 (Flt-1) mimics preeclamptic plasma in inhibiting uterine blood vessel relaxation in pregnancy: implications in the pathogenesis of preeclampsia.

1999 • 66 citations

Endothelial cell activation as a pathogenetic factor in preeclampsia.

1991 • 59 citations

Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression

1991 • 50 citations

Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia

2008 • 50 citations

Differential Effects of Vascular Endothelial Growth Factor-C and Placental Growth Factor-1 on the Hydraulic Conductivity of Frog Mesenteric Capillaries

2001 • 49 citations

The Conformation-Dependent Interaction of alpha sub2 -Macroglobulin with Vascular Endothelial Growth Factor: A Novel Mechanism of alpha sub2 -Macroglobulin/Growth Factor Binding

2000 • 49 citations

Preeclamptic Sera Stimulate Increased Platelet‐Derived Growth Factor mRNA and Protein Expression by Cultured Human Endothelial Cells

1991 • 46 citations

The anti‐angiogenic VEGF isoform VEGF₁₆₅b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo

2006 • 44 citations

Amniotic vascular endothelial growth factor (VEGF) and nitric oxide (NO) in women with subsequent preeclampsia

2003 • 41 citations

Bioactivity of the Vascular Endothelial Growth Factor Trapped in Fibrin Clots: Production of IL-6 and IL-8 in Monocytes by Fibrin Clots

2001 • 41 citations

The Conformation-dependent Interaction of α2-Macroglobulin with Vascular Endothelial Growth Factor

2000 • 41 citations

Vascular Dysfunction Induced by AGE is Mediated by VEGF via Mechanisms Involving Reactive Oxygen Species, Guanylate Cyclase, and Protein Kinase C

2001 • 39 citations

The effects of vascular endothelial growth factor on endothelial cells: A potential role in preeclampsia

2000 • 38 citations

Maternal plasma VEGF, sVEGF-R1, and PlGF concentrations in preeclamptic and normotensive pregnant Zimbabwean women.

2005 • 37 citations

Serum Levels of Macrophage Colony Stimulating, Vascular Endothelial, and Placenta Growth Factor in Relation to Later Clinical Onset of Pre‐Eclampsia and a Small‐for‐Gestational Age Birth

2005 • 35 citations

Impaired vascular permeability regulation caused by the VEGF165b splice variant in pre-eclampsia

2011 • 31 citations

Vascular Dysfunction Induced by AGE is Mediated by VEGF via Mechanisms Involving Reactive Oxygen Species, Guanylate Cyclase, and Protein Kinase C

2001 • 30 citations

Umbilical cord serum vascular endothelial growth factor (VEGF) levels in normal pregnancies and in pregnancies complicated by preterm delivery or pre‐eclampsia

2004 • 26 citations

Increased Endothelial Monocyte Chemoattractant Protein-1 and Interleukin-8 in Preeclampsia

2002 • 21 citations

Plasma from women with severe pre-eclampsia increases microvascular permeability in an animal model in vivo

2004 • 18 citations

Altered subcellular distribution of cadherin-5 in endothelial cells caused by the serum of pre-eclamptic patients

2000 • 15 citations

Reduced Cellular Glutathione Reductase Activity and Increased Adhesion Molecule Expression in Endothelial Cells Cultured With Maternal Plasma From Women With Preeclampsia

2006 • 13 citations

High levels of urinary vascular endothelial growth factor in women with severe preeclampsia

2004 • 12 citations

Plasma From Preeclamptic Women Stimulates Decidual Endothelial Cell Growth and Prostacyclin but Not Nitric Oxide Production: Close Correlation of Prostacyclin and Thromboxane Production

2001 • 12 citations

High Levels of Urinary Vascular Endothelial Growth Factor in Women with Severe Preeclampsia

2004 • 9 citations

Plasma from preeclamptic women stimulates decidual endothelial cell growth and prostacyclin but not nitric oxide production: close correlation of prostacyclin and thromboxane production

2001 • 9 citations

Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression

1992 • 3 citations