Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch Signaling

1995 • 1,282 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Conservation of the Notch signalling pathway in mammalian neurogenesis

1997 • 617 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

1995 • 594 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 • 476 citations

Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J _κ

1994 • 462 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

1995 • 430 citations

Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina

1997 • 425 citations

Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch

1995 • 409 citations

Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.

1994 • 395 citations

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

1997 • 380 citations

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

1996 • 372 citations

Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing

1997 • 369 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system

1997 • 364 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

Chapter 10 Manipulating Gene Expression with Replication--Competent Retroviruses

1996 • 344 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

1996 • 331 citations

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila

1996 • 331 citations

Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis

1996 • 322 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells

1994 • 298 citations

Xotch inhibits cell differentiation in the xenopus retina

1995 • 293 citations

Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

1997 • 289 citations

Recognition sequence of a highly conserved DNA binding protein RBP-J_x

1994 • 287 citations

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

1997 • 287 citations

The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo

1994 • 283 citations

Regulation of neuronal diversity in the Xenopus retina by Delta signalling

1997 • 274 citations

Delta-Notch Signaling and Drosophila Cell Fate Choice

1994 • 268 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)

1996 • 232 citations

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

1993 • 211 citations

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

1997 • 207 citations

S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues

1993 • 198 citations

Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos

1998 • 193 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos

1997 • 186 citations

Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription

1997 • 176 citations

The TAFs in the HAT

1998 • 155 citations

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling

1997 • 155 citations

Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.

1994 • 154 citations

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs

1997 • 152 citations

Wag the Tail: Structural Dynamics of Actomyosin

1998 • 140 citations

bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes

1994 • 113 citations

The Role of Notch in Lateral Inhibition and Cell Fate Specification

1995 • 109 citations

Delta-1 Is a Regulator of Neurogenesis in the Vertebrate Retina

1997 • 81 citations

The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.

1991 • 67 citations

Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells

1989 • 65 citations

Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins

1995 • 61 citations

JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial–mesenchymal interactions

1997 • 60 citations

Autonomous differentiation in the mouse myogenic cell line, C2, involves a mutual positive control between insulin-like growth factor II and MyoD, operating as early as at the myoblast stage

1996 • 60 citations

Suppressor of Hairless, the Drosophila homologue of RBP-J.KAPPA., transactivates the neurogenic gene E(spl)m8.

1995 • 55 citations

Synergy between Suppressor of Hairless and Notch in Regulation of Enhancer of split mγ and mδ Expression

1997 • 54 citations

Deleted Work

1955 • 0 citations