Degradation of Misfolded Proteins Prevents ER-Derived Oxidative Stress and Cell Death

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2001 • 2,167 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

1999 • 1,494 citations

Oxygen Stress: A Regulator of Apoptosis in Yeast

1999 • 1,012 citations

Oxidative protein folding in eukaryotes

2004 • 990 citations

A Caspase-Related Protease Regulates Apoptosis in Yeast

2002 • 868 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

A Yeast Mutant Showing Diagnostic Markers of Early and Late Apoptosis

1997 • 788 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Oxidants in mitochondria: from physiology to diseases

1995 • 543 citations

A regulatory link between ER-associated protein degradation and the unfolded-protein response.

2000 • 459 citations

The FAD- and O2-Dependent Reaction Cycle of Ero1-Mediated Oxidative Protein Folding in the Endoplasmic Reticulum

2002 • 422 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

Ero1p Oxidizes Protein Disulfide Isomerase in a Pathway for Disulfide Bond Formation in the Endoplasmic Reticulum

1999 • 369 citations

Regulation of Glucose Metabolism in Growing Yeast Cells

1981 • 367 citations

Competition between glutathione and protein thiols for disulphide-bond formation

1999 • 309 citations

INTRACELLULAR SIGNALING FROM THE ENDOPLASMIC RETICULUM TO THE NUCLEUS

1998 • 258 citations

Endoplasmic reticulum dysfunction – a common denominator for cell injury in acute and degenerative diseases of the brain?

2001 • 244 citations

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson’s disease

1998 • 231 citations

Disrupted Proteolipid Protein Trafficking Results in Oligodendrocyte Apoptosis in an Animal Model of Pelizaeus-Merzbacher Disease

1998 • 217 citations

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1993 • 205 citations

Degradation of Endoplasmic Reticulum (ER) Quality Control Substrates Requires Transport between the ER and Golgi

2001 • 172 citations

Molecular basis of autosomal dominant neurohypophyseal diabetes insipidus. Cellular toxicity caused by the accumulation of mutant vasopressin precursors within the endoplasmic reticulum.

1997 • 171 citations

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

2002 • 151 citations

The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

1992 • 150 citations

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

2001 • 134 citations

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

2002 • 130 citations

An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

2002 • 123 citations

Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex.

1994 • 116 citations

Impaired mitochondrial function protects against free radical-mediated cell death

2002 • 35 citations

Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiae

1997 • 20 citations

Cited By (0)

Loading...