Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

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Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

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Neuronal Regulation of Glutamate Transporter Subtype Expression in Astrocytes

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The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Astrocytes: Glutamate producers for neurons

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Substitution of a mutant α _2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

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Abnormal Regulation of the Sympathetic Nervous System in α_2A-Adrenergic Receptor Knockout Mice

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Pharmacological profiles of medetomidine and its antagonist, atipamezole.

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Neurotransmitters as developmental signals

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Dexmedetomidine Diminishes Halothane Anesthetic Requirements in Rats Through a Postsynaptic Alpha2 Adrenergic Receptor

1988 • 227 citations

Volatile Anesthetics Depress Glutamate Transmission Via Presynaptic Actions

1996 • 198 citations

Dexmedetomidine Produces a Hypnotic–Anesthetic Action in Rats via Activation of Central Alpha-2 Adrenoceptors

1989 • 195 citations

Genetic Alteration of α_2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α₂-Adrenoceptor Agonist

1997 • 165 citations

Increase of Glutamate Uptake in Astrocytes

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Functional Studies in Cultured Astrocytes

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Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action

1994 • 129 citations

Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors

1998 • 119 citations

Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes.

1998 • 104 citations

Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat.

1996 • 103 citations

α2A- But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data

1999 • 94 citations

Hippocampal ?2A-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes

1998 • 91 citations

α2A-adrenergic receptors in the rat nucleus locus coeruleus: subcellular localization in catecholaminergic dendrites, astrocytes, and presynaptic axon terminals

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Effects of Dexmedetomidine on Hypoxia-evoked Glutamate Release and Glutamate Receptor Activity in Hippocampal Slices

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Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine

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Absence of preferential glutamine uptake into neurons — an indication of a net transfer of TCA constituents from nerve endings to astrocytes?

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α₁ and α₂ Adrenergic receptors in mouse brain astrocytes from primary cultures

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Anesthetic Properties of Riluzole (54274 RP), a New Inhibitor of Glutamate Neurotransmission

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Pharmacological Characteristics of Alpha‐2 Adrenergic Receptor Subtypes

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Glutamine transport in cerebellar granule cells in culture

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Dexmedetomidine-Induced Stimulation of Glutamine Oxidation in Astrocytes: A Possible Mechanism for its Neuroprotective Activity

2000 • 59 citations

Ultrastructural evidence for prominent postsynaptic localization of ?2C-adrenergic receptors in catecholaminergic dendrites in the rat nucleus locus coeruleus

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Riluzole Anesthesia

1996 • 52 citations

Coupling of Astroglial α₂‐Adrenoreceptors to Second Messenger Pathways

1996 • 47 citations

Noradrenaline effects on pyruvate decarboxylation: Correlation with calcium signaling

1999 • 34 citations

A Correlation Between Dexmedetomidine-Induced Biphasic Increases in Free Cytosolic Calcium Concentration and Energy Metabolism in Astrocytes

2000 • 33 citations

Depression of NMDA receptor‐mediated synaptic transmission by four α₂ adrenoceptor agonists on the in vitro rat spinal cord preparation

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The α2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro

1991 • 28 citations

Noradrenaline‐induced stimulation of glutamine metabolism in primary cultures of astrocytes

1995 • 24 citations

Single dose pharmacokinetics of medetomidine in sheep

1996 • 24 citations

Dexmedetomidine, a potent and highly specific alpha2 agonist, evokes cytosolic calcium surge in astrocytes but not in neurons

1992 • 23 citations

Chapter 24: Effects of monoamine transmitters on neurons and astrocytes: correlation between energy metabolism and intracellular messengers

1992 • 23 citations

The effects of α2-adrenoceptor stimulation on neocortical EEG activity in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats

1993 • 21 citations

Actions of morphine on noradrenaline efflux in the rat locus coeruleus are mediated via both opioid and α2 adrenoceptor mechanisms

1995 • 18 citations

Stereoselective effects of central α2-adrenergic agonist medetomidine on in vivo catechol activity in the rat rostral ventrolateral medulla (RVLM)

1992 • 17 citations

Chronic Desipramine Treatment Desensitizes the Rat to Anesthetic and Antinociceptive Effects of the α2-adrenergicAgonist Dexmedetomidine

1998 • 13 citations

Regulation of α_2A‐Adrenergic Receptor Expression by Epinephrine in Cultured Astroglia from Rat Brain

1998 • 12 citations

Clonidine enhances astrocytic glutamine uptake by authentic α2-adrenoceptor stimulation

1994 • 5 citations