The α2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro

Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist

1988 • 676 citations

Determination and Applications of MAC

1980 • 593 citations

Reduced Narcotic Requirement by Clonidine with Improved Hemodynamic and Adrenergic Stability in Patients Undergoing Coronary Bypass Surgery

1987 • 455 citations

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

1986 • 388 citations

Cyclic adenosine 3',5'‐monophosphate mediates beta‐receptor actions of noradrenaline in rat hippocampal pyramidal cells.

1986 • 308 citations

Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones

1985 • 246 citations

Dexmedetomidine Diminishes Halothane Anesthetic Requirements in Rats Through a Postsynaptic Alpha2 Adrenergic Receptor

1988 • 227 citations

Dexmedetomidine Produces a Hypnotic–Anesthetic Action in Rats via Activation of Central Alpha-2 Adrenoceptors

1989 • 195 citations

Noradrenergic responses in rat hippocampus: Evidence for mediation by α and β receptors in the in vitro slice

1981 • 194 citations

Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus

1985 • 184 citations

Reduction in Halothane Anesthetic Requirement by Clonidine, an Alpha-Adrenergic Agonist

1982 • 183 citations

Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole.

1989 • 180 citations

Determination of Anesthetic Requirement in Rats

1974 • 174 citations

Norepinephrine decreases synaptic inhibition in the rat hippocampus

1988 • 165 citations

EVIDENCE FOR MEDETOMIDINE AS A SELECTIVE AND POTENT AGONIST α₂‐ADRENORECEPTORS

1986 • 145 citations

Anesthetic and Hemodynamic Effects of the Stereoisomers of Medetomidine, an ??2-Adrenergic Agonist, in Halothane-Anesthetized Dogs

1988 • 145 citations

Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: an intracellular study

1987 • 134 citations

Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'- monophosphate analogues

1985 • 132 citations

Medetomidine — a novel α2-adrenoceptor agonist: A review of its pharmacodynamic effects

1989 • 129 citations

INHALATION ANAESTHETICS EXHIBIT PATHWAY-SPECIFIC AND DIFFERENTIAL ACTIONS ON HIPPOCAMPAL SYNAPTIC RESPONSES IN VITRO

1988 • 100 citations

Dexmedetomidine Premedication for Minor Gynecologic Surgery

1990 • 91 citations

The Potentiation of Halothane Anaesthesia by Clonidine

1979 • 82 citations

Noradrenaline modulates the release of [14C]glutamate from dentate but not from CA1/CA3 slices of rat hippocampus

1986 • 62 citations

Noradrenergic depression of synaptic responses in hippocampus of rat: Evidence for mediation by alpha1-receptors

1988 • 61 citations

GENERAL ANAESTHETIC MODIFICATION OF SYNAPTIC FACILITATION AND LONG-TERM POTENTIATION IN HIPPOCAMPUS

1989 • 48 citations

Anaesthesia: The role of adrenergic mechanisms

1983 • 40 citations

Isoflurane-induced impairment of synaptic transmission in hippocampal neurons

1989 • 39 citations

Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance.

1990 • 33 citations

Selective depression of hippocampal inhibitory postsynaptic potentials and spontaneous firing by volatile anesthestics

1985 • 33 citations

Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance

1990 • 30 citations

Isoflurane effects in rat hippocampal cortex: a quantitative evaluation of different cellular sites of action

1986 • 25 citations

The use of brain slices in central nervous system pharmacology.

1983 • 22 citations

Endogenously released opioids inhibit inhibitory post synaptic potentials in guinea pig CA3 pyramidal cells and rat dentate granule cells.

1990 • 9 citations

ANTINOCICEPTIVE EFFECTS OF INTRATHECAL DEXMEDETOMIDINE IN RATS

1990 • 2 citations